Delay Discounting as a Potential Therapeutic Target for Weight Loss in Breast Cancer Survivors

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dc.contributor.authorSukumar, Jasmine S.en
dc.contributor.authorVaughn, Jennifer E.en
dc.contributor.authorTegge, Allisonen
dc.contributor.authorSardesai, Sagaren
dc.contributor.authorLustberg, Maryamen
dc.contributor.authorStein, Jeffreyen
dc.date.accessioned2022-07-21T15:02:16Zen
dc.date.available2022-07-21T15:02:16Zen
dc.date.issued2022-03en
dc.description.abstractSimple Summary Obesity is a rising health epidemic in breast cancer survivors and associated with multiple negative health sequalae and increased mortality. Delay Discounting (DD) is a behavioral economic measure of an individual's valuation of future outcomes. While higher DD correlates with obesity in the general adult population, valuation of the future may impact cancer survivors differently due to their unique experiences. We assessed cross-sectional associations between DD, BMI, and healthy lifestyle behaviors in an exploratory analysis of 89 women with hormone receptor positive non-metastatic breast cancer. We found higher DD to be associated with obesity and decreased frequency of vegetable consumption. Future studies should investigate DD as a therapeutic target for novel behavioral interventions in breast cancer survivors affected by obesity. This may improve valuation of the future, increase healthy lifestyle behaviors, and facilitate weight loss to promote overall health and longevity in this population. Obesity in breast cancer (BC) survivors is associated with increased mortality. Delay discounting (DD) is a behavioral economic measure of how individuals value future outcomes. Higher DD correlates with obesity in the general population. Valuation of the future may be associated with obesity differently in cancer survivors. This study evaluated the relationship between DD and obesity in BC survivors. We report an exploratory analysis assessing cross-sectional associations between DD, BMI, and lifestyle behaviors (vegetable and fruit consumption, exercise) related to obesity in 89 women with hormone receptor positive non-metastatic BC. Multivariate linear regression analysis examined demographic and lifestyle behavior variables associated with both BMI and DD. Greater willingness to wait for larger, delayed rewards (lower DD) was significantly associated with lower BMI (standardized beta = -0.32; p < 0.01), independent of age, race, income, time since diagnosis, and menopausal status. There was no significant association between DD and fruit consumption or exercise frequency. Vegetable consumption was significantly associated with lower DD (standardized beta = 0.24; p < 0.05). Higher DD is associated with obesity and decreased frequency of vegetable consumption in BC survivors. Future studies should investigate DD as a therapeutic target for behavioral interventions to facilitate weight loss and promote longevity in this population.en
dc.description.notesThis work was supported by a pilot feasibility grant from the Center for Health Behaviors Research, Fralin Biomedical Research Institute and Carilion Clinic to foster interdisciplinary collaborations in the study of health behaviors.en
dc.description.sponsorshipCenter for Health Behaviors Research, Fralin Biomedical Research Institute; Carilion Clinicen
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3390/cancers14051134en
dc.identifier.eissn2072-6694en
dc.identifier.issue5en
dc.identifier.other1134en
dc.identifier.pmid35267441en
dc.identifier.urihttp://hdl.handle.net/10919/111308en
dc.identifier.volume14en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectdelay discountingen
dc.subjectbreast canceren
dc.subjectobesityen
dc.subjectsurvivorshipen
dc.subjectbehavioral healthen
dc.titleDelay Discounting as a Potential Therapeutic Target for Weight Loss in Breast Cancer Survivorsen
dc.title.serialCancersen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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