Diagnostic interchangeability of deep convolutional neural networks reconstructed knee MR images: preliminary experience

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dc.contributor.authorSubhas, Naveenen
dc.contributor.authorLi, Hongyuen
dc.contributor.authorYang, Mingruien
dc.contributor.authorWinalski, Carl S.en
dc.contributor.authorPolster, Joshuaen
dc.contributor.authorObuchowski, Nancyen
dc.contributor.authorMamoto, Kenjien
dc.contributor.authorLiu, Ruiyingen
dc.contributor.authorZhang, Chaoyien
dc.contributor.authorHuang, Peizhouen
dc.contributor.authorGaire, Sunil Kumaren
dc.contributor.authorLiang, Dongen
dc.contributor.authorShen, Bowenen
dc.contributor.authorXiaojuan, Lien
dc.contributor.authorYing, Leslieen
dc.contributor.departmentComputer Scienceen
dc.date.accessioned2020-12-14T15:46:03Zen
dc.date.available2020-12-14T15:46:03Zen
dc.date.issued2020-09en
dc.description.abstractBackground: MRI acceleration using deep learning (DL) convolutional neural networks (CNNs) is a novel technique with great promise. Increasing the number of convolutional layers may allow for more accurate image reconstruction. Studies on evaluating the diagnostic interchangeability of DL reconstructed knee magnetic resonance (MR) images are scarce. The purpose of this study was to develop a deep CNN (DCNN) with an optimal number of layers for accelerating knee magnetic resonance imaging (MRI) acquisition by 6-fold and to test the diagnostic interchangeability and image quality of nonaccelerated images versus images reconstructed with a 15-layer DCNN or 3-layer CNN. Methods: For the feasibility portion of this study, 10 patients were randomly selected from the Osteoarthritis Initiative (OAI) cohort. For the interchangeability portion of the study, 40 patients were randomly selected from the OAI cohort. Three readers assessed meniscal and anterior cruciate ligament (ACL) tears and cartilage defects using DCNN, CNN, and nonaccelerated images. Image quality was subjectively graded as nondiagnostic, poor, acceptable, or excellent. Interchangeability was tested by comparing the frequency of agreement when readers used both accelerated and nonaccelerated images to frequency of agreement when readers only used nonaccelerated images. A noninferiority margin of 0.10 was used to ensure type I error <= 5% and power >= 80%. A logistic regression model using generalized estimating equations was used to compare proportions; 95% confidence intervals (CIs) were constructed. Results: DCNN and CNN images were interchangeable with nonaccelerated images for all structures, with excess disagreement values ranging from -2.5% [95% CI: (-6.1, 1.1)] to 3.0% [95% CI: (-0.1, 6.1)]. The quality of DCNN images was graded higher than that of CNN images but less than that of nonaccelerated images [excellent/acceptable quality: DCNN, 95% of cases (114/120); CNN, 60% (72/120); nonaccelerated, 97.5% (117/120)]. Conclusions: Six-fold accelerated knee images reconstructed with a DL technique are diagnostically interchangeable with nonaccelerated images and have acceptable image quality when using a 15-layer CNN.en
dc.description.notesThis work was supported in part by the National Institutes of Health R21EB020861. This study was also partially supported by a Society of Skeletal Radiology (SSR) Research Seed Grant ("Highly Accelerated Knee MRI using a Novel Deep Convolutional Neural Network Algorithm: A Multi-Reader Comparison Study").en
dc.description.sponsorshipNational Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R21EB020861]; Society of Skeletal Radiology (SSR) Research Seed Grant ("Highly Accelerated Knee MRI using a Novel Deep Convolutional Neural Network Algorithm: A Multi-Reader Comparison Study")en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.21037/qims-20-664en
dc.identifier.eissn2223-4306en
dc.identifier.issn2223-4292en
dc.identifier.issue9en
dc.identifier.pmid32879854en
dc.identifier.urihttp://hdl.handle.net/10919/101109en
dc.identifier.volume10en
dc.language.isoenen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectDeep learning (DL)en
dc.subjectartificial intelligenceen
dc.subjectMRI acceleration techniqueen
dc.subjectknee MRIen
dc.titleDiagnostic interchangeability of deep convolutional neural networks reconstructed knee MR images: preliminary experienceen
dc.title.serialQuantitative Imaging in Medicine And Surgeryen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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