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Treatment of a Spinal Cord Hemitransection Injury with Keratin Biomaterial Hydrogel Elicits Recovery and Tissue Repair

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dc.contributor.authorFearing, Bailey V.en
dc.contributor.authorHartley, Christopheren
dc.contributor.authorDayton, Orrinen
dc.contributor.authorSherwood, Garretten
dc.contributor.authorAbouShwareb, Tameren
dc.contributor.authorVan Dyke, Mark E.en
dc.contributor.departmentSchool of Biomedical Engineering and Sciencesen
dc.date.accessioned2017-09-18T09:42:11Zen
dc.date.available2017-09-18T09:42:11Zen
dc.date.issued2014-03-23en
dc.date.updated2017-09-18T09:42:11Zen
dc.description.abstractMedical care costs can reach an estimated value of $4 billion for spinal cord injuries (SCI) each year in the USA alone. With no viable treatment options available, care remains palliative and aims to minimize lifelong disabilities and complications, such as immobility, bladder and bowel dysfunction, breathing problems, and blood clots. Human hair keratin biomaterials have demonstrated efficacy in peripheral nerve injury models and were shown to improve conduction delay and increase axon number and density. In this study, a keratin hydrogel was tested in a central nervous system (CNS) application of spinal cord hemisection injury. Keratin-treated rats showed increased survival rates as well as a better functional recovery of gait properties and bladder function. Histological results demonstrated reduced glial scar formation with keratin treatment and suggested a greater degree of beneficial remodeling and cellular influx. The data provided in this pilot study suggest the possibility of using a keratin-based treatment for SCI and warrant further investigation.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBailey V. Fearing, Christopher Hartley, Orrin Dayton, Garrett Sherwood, Tamer AbouShwareb, and Mark E. Van Dyke, “Treatment of a Spinal Cord Hemitransection Injury with Keratin Biomaterial Hydrogel Elicits Recovery and Tissue Repair,” ISRN Biomaterials, vol. 2014, Article ID 426047, 9 pages, 2014. doi:10.1155/2014/426047en
dc.identifier.doihttps://doi.org/10.1155/2014/426047en
dc.identifier.urihttp://hdl.handle.net/10919/78962en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2014 Bailey V. Fearing et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleTreatment of a Spinal Cord Hemitransection Injury with Keratin Biomaterial Hydrogel Elicits Recovery and Tissue Repairen
dc.title.serialISRN Biomaterialsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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