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Prevalence and Prognostic Importance of Pulmonary Hypertension in Dogs with Myxomatous Mitral Valve Disease

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dc.contributor.authorBorgarelli, Micheleen
dc.contributor.authorAbbott, Jonathan A.en
dc.contributor.authorBraz-Ruivo, L.en
dc.contributor.authorChiavegato, D.en
dc.contributor.authorCrosara, S.en
dc.contributor.authorLamb, K.en
dc.contributor.authorLjungvall, Ingriden
dc.contributor.authorPoggi, M.en
dc.contributor.authorSantilli, Roberto A.en
dc.contributor.authorHaggstrom, Jensen
dc.date.accessioned2019-08-08T12:44:50Zen
dc.date.available2019-08-08T12:44:50Zen
dc.date.issued2015-03en
dc.description.abstractBackgroundPulmonary hypertension (PH) is common in dogs with myxomatous mitral valve disease (MMVD) but its effect on clinical outcome has not been investigated. Hypothesis/objectivesThe presence of PH worsens the outcome in dogs with MMVD. To compare survival times of dogs with MMVD and PH to those without PH. AnimalsTwo hundred and twelve client-owned dogs. MethodsCase review study. Medical records of dogs diagnosed with ACVIM stage B2 and C MMVD between January 2010 and December 2011 were retrospectively reviewed. Long-term outcome was determined by telephone interview or from the medical record. End of the observation period was March 2013. PH was identified if tricuspid regurgitation peak velocity was >3m/s. ResultsTwo hundred and twelve were identified. Eighty-three dogs (39%) had PH. PH was more commonly identified in stage C compared to B2 (P<.0001). One hundred and five (49.5%) dogs died during the observation period. Median survival time for the entire study population was 567days (95% CI 512-743). Stage C (P=.003), the presence of PH (P=.009), left atrial to aortic root ratio (LA/Ao) >1.7 (P=.0002), normalized left-ventricular end-diastolic diameter (LVEDn) >1.73 (P=.048), and tricuspid regurgitation pressure gradient (TRPG) >55mmHg (P=.009) were associated with worse outcomes in the univariate analyses. The presence of TRPG >55mmHg (HR 1.8 95% CI 1-2.9; P=.05) and LA/Ao>1.7 (HR 2 95% CI 1.2-3.4; P=.01) remained significant predictors of worse outcome in the multivariate analysis. Conclusions and Clinical ImportanceIn dogs with MMVD, moderate to severe PH worsens outcome.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/jvim.12564en
dc.identifier.eissn1939-1676en
dc.identifier.issn0891-6640en
dc.identifier.issue2en
dc.identifier.pmid25818210en
dc.identifier.urihttp://hdl.handle.net/10919/92885en
dc.identifier.volume29en
dc.language.isoenen
dc.publisherAmerican College of Veterinary Internal Medicineen
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectCanineen
dc.subjectDoppler echocardiographyen
dc.subjectEchocardiographyen
dc.subjectHeart failureen
dc.subjectHeart valveen
dc.titlePrevalence and Prognostic Importance of Pulmonary Hypertension in Dogs with Myxomatous Mitral Valve Diseaseen
dc.title.serialJournal of Veterinary Internal Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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