Abscisic Acid: A Novel Nutraceutical for Glycemic Control

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dc.contributor.authorZocchi, Elenaen
dc.contributor.authorHontecillas, Raquelen
dc.contributor.authorLeber, Andrewen
dc.contributor.authorEinerhand, Alexandraen
dc.contributor.authorCarbo, Adriaen
dc.contributor.authorBruzzone, Santinaen
dc.contributor.authorTubau-Juni, Nuriaen
dc.contributor.authorPhilipson, Noahen
dc.contributor.authorZoccoli-Rodriguez, Victoriaen
dc.contributor.authorSturla, Lauraen
dc.contributor.authorBassaganya-Riera, Josepen
dc.date.accessioned2019-10-30T13:05:08Zen
dc.date.available2019-10-30T13:05:08Zen
dc.date.issued2017-06-13en
dc.description.abstractAbscisic acid is naturally present in fruits and vegetables, and it plays an important role in managing glucose homeostasis in humans. According to the latest U.S. dietary survey, about 92% of the population might have a deficient intake of ABA due to their deficient intake of fruits and vegetables. This review summarizes the in vitro, preclinical, mechanistic, and human translational findings obtained over the past 15 years in the study of the role of ABA in glycemic control. In 2007, dietary ABA was first reported to ameliorate glucose tolerance and obesity-related inflammation in mice. The most recent findings regarding the topic of ABA and its proposed receptor lanthionine synthetase C-like 2 in glycemic control and their interplay with insulin and glucagon-like peptide-1 suggest a major role for ABA in the physiological response to a glucose load in humans. Moreover, emerging evidence suggests that the ABA response might be dysfunctional in diabetic subjects. Follow on intervention studies in healthy individuals show that low-dose dietary ABA administration exerts a beneficial effect on the glycemia and insulinemia profiles after oral glucose load. These recent findings showing benefits in humans, together with extensive efficacy data in mouse models of diabetes and inflammatory disease, suggest the need for reference ABA values and its possible exploitation of the glycemia-lowering effects of ABA for preventative purposes. Larger clinical studies on healthy, prediabetic, and diabetic subjects are needed to determine whether addressing the widespread dietary ABA deficiency improves glucose control in humans.en
dc.description.notesThis paper was supported by NIH/NIDDK grant R43DK109836. This work was also supported in part by the Italian Ministry of Education, University and Scientific Research (grants PRIN # 2007BZ4RX3_005 and FIRB 2012#RBFR1299K0_002), by the Fondazione CARIGE, by the Compagnia di S. Paolo di Torino (grant #2012-ID ROL 316), by the University of Genova (PRA2012), and by Regione Liguria.en
dc.description.sponsorshipNIH/NIDDKUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [R43DK109836]; Italian Ministry of Education, University and Scientific ResearchMinistero dell' Istruzione, dell' Universita e della Ricerca (MIUR) [2007BZ4RX3_005, RBFR1299K0_002]; Fondazione CARIGE; Compagnia di S. Paolo di TorinoCompagnia di San Paolo [2012-ID ROL 316]; University of Genova (PRA); Regione Liguriaen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fnut.2017.00024en
dc.identifier.issn2296-861Xen
dc.identifier.otherUNSP 24en
dc.identifier.pmid28660193en
dc.identifier.urihttp://hdl.handle.net/10919/95213en
dc.identifier.volume4en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectlanthionine synthetase C-like 2en
dc.subjectabscisic aciden
dc.subjectdiabetesen
dc.subjectprediabetesen
dc.subjectmetabolic syndromeen
dc.titleAbscisic Acid: A Novel Nutraceutical for Glycemic Controlen
dc.title.serialFrontiers in Nutritionen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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