Belief about nicotine selectively modulates value and reward prediction error signals in smokers

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dc.contributorVirginia Techen
dc.contributor.authorGu, Xiaosien
dc.contributor.authorLohrenz, Terryen
dc.contributor.authorSalas, Ramiroen
dc.contributor.authorBaldwin, Philip R.en
dc.contributor.authorSoltani, Alirezaen
dc.contributor.authorKirk, Ulrichen
dc.contributor.authorCinciripini, Paul M.en
dc.contributor.authorMontague, P. Readen
dc.date.accessioned2017-09-08T14:18:49Zen
dc.date.available2017-09-08T14:18:49Zen
dc.date.issued2015-02-24en
dc.description.abstractLittle is known about how prior beliefs impact biophysically described processes in the presence of neuroactive drugs, which presents a profound challenge to the understanding of the mechanisms and treatments of addiction. We engineered smokers’ prior beliefs about the presence of nicotine in a cigarette smoked before a functional magnetic resonance imaging session where subjects carried out a sequential choice task. Using a model-based approach, we show that smokers’ beliefs about nicotine specifically modulated learning signals (value and reward prediction error) defined by a computational model of mesolimbic dopamine systems. Belief of “no nicotine in cigarette” (compared with “nicotine in cigarette”) strongly diminished neural responses in the striatum to value and reward prediction errors and reduced the impact of both on smokers’ choices. These effects of belief could not be explained by global changes in visual attention and were specific to value and reward prediction errors. Thus, by modulating the expression of computationally explicit signals important for valuation and choice, beliefs can override the physical presence of a potent neuroactive compound like nicotine. These selective effects of belief demonstrate that belief can modulate modelbased parameters important for learning. The implications of these findings may be far ranging because belief-dependent effects on learning signals could impact a host of other behaviors in addiction as well as in other mental health problems.en
dc.identifier.doihttps://doi.org/10.1073/pnas.1416639112en
dc.identifier.issue8en
dc.identifier.urihttp://hdl.handle.net/10919/78832en
dc.identifier.volume112en
dc.language.isoen_USen
dc.publisherNASen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectnicotine addictionen
dc.subjectbeliefen
dc.subjectreinforcement learningen
dc.subjectdopamineen
dc.subjectfMRIen
dc.titleBelief about nicotine selectively modulates value and reward prediction error signals in smokersen
dc.title.serialPNASen
dc.typeArticle - Refereeden

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Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, Fralin Biomedical Research Institute at VTC