Decision-making in stimulant and opiate addicts in protracted abstinence: evidence from computational modeling with pure users

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dc.contributor.authorAhn, Woo-Youngen
dc.contributor.authorVasilev, Georgien
dc.contributor.authorLee, Sung Haen
dc.contributor.authorBusemeyer, Jerome R.en
dc.contributor.authorKruschke, John K.en
dc.contributor.authorBechara, Antoineen
dc.contributor.authorVassileva, Jasminen
dc.date.accessioned2019-05-28T14:50:20Zen
dc.date.available2019-05-28T14:50:20Zen
dc.date.issued2014-08-12en
dc.description.abstractSubstance dependent individuals (SDI) often exhibit decision-making deficits; however, it remains unclear whether the nature of the underlying decision-making processes is the same in users of different classes of drugs and whether these deficits persist after discontinuation of drug use. We used computational modeling to address these questions in a unique sample of relatively “pure” amphetamine-dependent (N=38) and heroin-dependent individuals (N=43) who were currently in protracted abstinence, and in 48 healthy controls. A Bayesian model comparison technique, a simulation method, and parameter recovery tests were used to compare three cognitive models: (1) Prospect Valence Learning with decay reinforcement learning rule (PVL-DecayRI), (2) PVL with delta learning rule (PVL-Delta), and (3) Value-Plus-Perseverance (VPP) models based on Win-Stay-Lose-Switch (WSLS) strategy. The model comparison results indicated that the VPP model, a hybrid model of reinforcement learning (RL) and a heuristic strategy of perseverance had the best post hoc model fit, but the two PVL models showed better simulation performance. Computational modeling results suggested that overall all three groups relied more on RL than on a WSLS strategy. Heroin users displayed reduced loss aversion relative to healthy controls across all three models, which suggests that their decision-making deficits are longstanding (or pre-existing) and may be driven by reduced sensitivity to loss. In contrast, amphetamine users showed comparable cognitive functions to healthy controls with the VPP model, whereas the second best-fitting model with relatively good simulation performance (PVL-DecayRI) revealed increased reward sensitivity relative to healthy controls. These results suggest that some decision-making deficits persist in protracted abstinence and may be mediated by different mechanisms in opiate and stimulant users.en
dc.description.sponsorshipNIDA NIH HHS (R01 DA021421) United Statesen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fpsyg.2014.00849en
dc.identifier.issn16641078en
dc.identifier.pmid25161631en
dc.identifier.urihttp://hdl.handle.net/10919/89620en
dc.identifier.volume5en
dc.language.isoenen
dc.publisherFrontiers Media S.A.en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectBayesian data analysisen
dc.subjectWidely Applicable Information Criterion (WAIC)en
dc.subjectaddictionen
dc.subjectamphetamineen
dc.subjectcomputational modelingen
dc.subjectdecision-makingen
dc.subjectheroinen
dc.subjectprotracted abstinenceen
dc.titleDecision-making in stimulant and opiate addicts in protracted abstinence: evidence from computational modeling with pure usersen
dc.title.serialFrontiers in Psychologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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