Trading Places-Switching Frataxin Function by a Single Amino Acid Substitution within the [Fe-S] Cluster Assembly Scaffold

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dc.contributor.authorDean, Dennis R.en
dc.contributor.authorDos Santos, Patricia C.en
dc.contributor.departmentBiochemistryen
dc.date.accessioned2019-10-22T17:51:29Zen
dc.date.available2019-10-22T17:51:29Zen
dc.date.issued2015-05en
dc.description.abstractSimple inorganic structures comprised of iron and sulfur are called [Fe-S] clusters. They likely represent one of the earliest prosthetic groups associated with the emergence of life on earth and continue to have essential roles in sustaining many metabolic processes in almost all existing life forms. For example, proteins that contain one or more [Fe-S] clusters, generally referred to as [Fe-S] proteins, are involved in a wide variety of important cellular functions, including energy transformations, catalysis, and regulation of gene expression. In recent years, the assembly of [Fe-S] clusters and their trafficking within biological systems has captured the attention of researchers because defects in the process can lead to disruption of important metabolic processes, which, in humans, is often manifested in a variety of pathological conditions.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pgen.1005192en
dc.identifier.issn1553-7404en
dc.identifier.issue5en
dc.identifier.otherUNSP e1005192en
dc.identifier.pmid25996679en
dc.identifier.urihttp://hdl.handle.net/10919/95022en
dc.identifier.volume11en
dc.language.isoenen
dc.publisherPLoSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleTrading Places-Switching Frataxin Function by a Single Amino Acid Substitution within the [Fe-S] Cluster Assembly Scaffolden
dc.title.serialPLOS Geneticsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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