Successful Treatment of a Large Soft Tissue Sarcoma With Irreversible Electroporation

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dc.contributor.authorNeal, Robert E. IIIen
dc.contributor.authorRossmeisl, John H. Jr.en
dc.contributor.authorGarcia, Paulo A.en
dc.contributor.authorLanz, Otto I.en
dc.contributor.authorHenao-Guerrero, Nataliaen
dc.contributor.authorDavalos, Rafael V.en
dc.contributor.departmentSchool of Biomedical Engineering and Sciencesen
dc.date.accessioned2017-11-08T16:02:09Zen
dc.date.available2017-11-08T16:02:09Zen
dc.date.issued2011-05-01en
dc.description.abstractIrreversible electroporation (IRE) is a promising technique for the focal treatment of pathologic tissues that involves placing minimally invasive electrodes within the targeted region. A series of short, intense electric pulses are then applied to destabilize the cell membrane, presumably by creating nanopores,¹ inducing cell death in a nonthermal manner.² The unique therapeutic mechanism of IRE does not rely on tissue temperature changes, as with hyperthermic or cryoablative procedures.³,⁴ Therefore, IRE preserves the extracellular matrix, major tissue vasculature, and other sensitive structures.⁵⁻⁷ Treated regions resolve rapidly,⁵ with submillimeter resolution between treated and unaffected cells,⁸ and are predictable with numerical modeling.⁹ Treatments promote an immune response,⁵,¹⁰,¹¹ are unaltered by blood flow, can be administered quickly (approximately 5 minutes), and can be visualized in real time.¹⁰,¹²en
dc.description.sponsorshipSupported by The Coulter Foundation (Miami, FL)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1200/JCO.2010.33.0902en
dc.identifier.issue13en
dc.identifier.urihttp://hdl.handle.net/10919/79998en
dc.identifier.volume29en
dc.language.isoenen
dc.publisherAmerican Society of Clinical Oncologyen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.titleSuccessful Treatment of a Large Soft Tissue Sarcoma With Irreversible Electroporationen
dc.title.serialJournal of Clinical Oncologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Destination Area: Global Systems Science (GSS)
Scholarly Works, School of Biomedical Engineering and Sciences