First case of New Delhi metallo-beta-lactamase in Klebsiella pneumoniae from Ecuador: An update for South America

Simple item page
dc.contributor.authorRomero-Alvarez, Danielen
dc.contributor.authorReyes, Jorgeen
dc.contributor.authorQuezada, Vivianaen
dc.contributor.authorSatan, Carolinaen
dc.contributor.authorCevallos, Nelsonen
dc.contributor.authorBarrera, Sofiaen
dc.contributor.authorTrueba, Gabrielen
dc.contributor.authorEscobar, Luis E.en
dc.contributor.authorVillacis, Jose E.en
dc.contributor.departmentFish and Wildlife Conservationen
dc.date.accessioned2019-08-21T17:43:58Zen
dc.date.available2019-08-21T17:43:58Zen
dc.date.issued2017-12en
dc.description.abstractObjectives: To describe a clinical case of Klebsiella pneumoniae harboring a New Delhi metallo-beta-lactamase (NDM) plasmid in Ecuador and to present a map of reports of NDM isolates in South America. Methods: The modified Hodge test, carbapenem inactivation method, imipenem-EDTA disk method (synergy), and Rapidec Carba NP test were used to identify antibiotic resistance mechanisms. The presence of resistance genes was explored with a conjugation assay, and molecular confirmation of NDM was performed by PCR and DNA sequencing. Plasmid characterization was conducted by PCR-based replicon typing. A literature review was performed in Google Scholar and PubMed to identify reports from South America. Results: An HIV-infected patient, who had never traveled abroad, developed a bloodstream infection caused by K. pneumoniae ST147 harboring the NDM-1 resistance gene in a plasmid from the IncA/C group. Local circulation of NDM has also been described in other South American countries, in particular in Colombia and Brazil, although published scientific records were not found for other countries. Conclusions: This report presents the first evidence of autochthonous circulation of the NDM-1 resistance gene harbored by an IncA/C plasmid isolated from a K. pneumoniae ST147 in Ecuador. Efforts should be implemented to monitor and characterize the spatial and temporal distribution of NDM in Ecuador and other countries of South America. (C) 2017 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.en
dc.description.notesJEV was supported by the Pontificia Universidad Catolica del Ecuador (Project L13341). The Instituto Nacional de Investigacion en Salud Publica "Dr. Leopoldo Izquieta Perez", Quito, Ecuador provided support to JR, JEV, and CS.en
dc.description.sponsorshipPontificia Universidad Catolica del Ecuador [L13341]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.ijid.2017.10.012en
dc.identifier.eissn1878-3511en
dc.identifier.issn1201-9712en
dc.identifier.pmid29081367en
dc.identifier.urihttp://hdl.handle.net/10919/93199en
dc.language.isoenen
dc.publisherInternational Society for Infectious Diseasesen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectNDMen
dc.subjectSouth Americaen
dc.subjectKlebsiella pneumoniaeen
dc.subjectAntibiotic resistanceen
dc.subjectPlasmiden
dc.titleFirst case of New Delhi metallo-beta-lactamase in Klebsiella pneumoniae from Ecuador: An update for South Americaen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S1201971217302680-main.pdf
Size:
493.51 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Scholarly Works, Fish and Wildlife Conservation
Destination Area: Global Systems Science (GSS)