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Turing-pattern model of scaffolding proteins that establish spatial asymmetry during the cell cycle of Caulobacter crescentus

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dc.contributor.authorXu, Chunruien
dc.contributor.authorTyson, John J.en
dc.contributor.authorCao, Yangen
dc.date.accessioned2023-08-15T14:43:04Zen
dc.date.available2023-08-15T14:43:04Zen
dc.date.issued2023-04en
dc.description.abstractThe crescent-shaped bacterium Caulobacter crescentus divides asymmetrically into a sessile (stalked) cell and a motile (flagellated) cell. This dimorphic cell division cycle is driven by the asymmetric appearance of scaffolding proteins at the cell's stalk and flagellum poles. The scaffolding proteins recruit enzyme complexes that phosphorylate and degrade a master transcription factor, CtrA, and the abundance and phosphorylation state of CtrA control the onset of DNA synthesis and the differentiation of stalked and flagellated cell types. In this study, we use a Turing-pattern mechanism to simulate the spatiotemporal dynamics of scaffolding proteins in Caulobacter and how they influence the abundance and intracellular distribution of CtrA similar to P. Our mathematical model captures crucial features of wild-type and mutant strains and predicts the distributions of CtrA similar to P and signaling proteins in mutant strains. Our model accounts for Caulobacter polar morphogenesis and shows how spatial localization and phosphosignaling cooperate to establish asymmetry during the cell cycle.en
dc.description.notesACKNOWLEDGMENTS This work was partially supported by the National Science Foundation (USA) under awards MCB-1613741 and CCF-1909122. The funding sources played no role in the design of the study, in the collection, analysis, and interpretation of data, and in writing the manuscript.en
dc.description.sponsorshipNational Science Foundation (USA) [MCB-1613741, CCF-1909122]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.isci.2023.106513en
dc.identifier.eissn2589-0042en
dc.identifier.issue4en
dc.identifier.other106513en
dc.identifier.pmid37128549en
dc.identifier.urihttp://hdl.handle.net/10919/116039en
dc.identifier.volume26en
dc.language.isoenen
dc.publisherCell Pressen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectpolar localizationen
dc.subjecthistidine kinaseen
dc.subjectdna-replicationen
dc.subjectprotease complexen
dc.subjecttemporal controlen
dc.subjectdivision cycleen
dc.subjectpopz formsen
dc.subjectregulatoren
dc.subjectorganizationen
dc.subjectmorphogenesisen
dc.titleTuring-pattern model of scaffolding proteins that establish spatial asymmetry during the cell cycle of Caulobacter crescentusen
dc.title.serialiScienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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