Hippocampal Subregions Express Distinct Dendritic Transcriptomes that Reveal Differences in Mitochondrial Function in CA2
| dc.contributor.author | Farris, Shannon | en |
| dc.contributor.author | Ward, James M. | en |
| dc.contributor.author | Carstens, Kelly E. | en |
| dc.contributor.author | Samadi, Mahsa | en |
| dc.contributor.author | Wang, Yu | en |
| dc.contributor.author | Dudek, Serena M. | en |
| dc.date.accessioned | 2020-02-28T20:52:13Z | en |
| dc.date.available | 2020-02-28T20:52:13Z | en |
| dc.date.issued | 2019-10-08 | en |
| dc.description.abstract | RNA localization is one mechanism neurons use to spatially and temporally regulate gene expression at synapses. Here, we test the hypothesis that cells exhibiting distinct forms of synaptic plasticity will have differences in dendritically localized RNAs. Indeed, we discover that each major subregion of the adult mouse hippocampus expresses a unique complement of dendritic RNAs. Specifically, we describe more than 1,000 differentially expressed dendritic RNAs, suggesting that RNA localization and local translation are regulated in a cell typespecific manner. Furthermore, by focusing Gene Ontology analyses on the plasticity-resistant CA2, we identify an enrichment of mitochondria-associated pathways in CA2 cell bodies and dendrites, and we provide functional evidence that these pathways differentially influence plasticity and mitochondrial respiration in CA2. These data indicate that differences in dendritic transcriptomes may regulate cell type-specific properties important for learning and memory and may influence region-specific differences in disease pathology. | en |
| dc.description.sponsorship | Research reported in this publication was supported by the National Institute of Mental Health of the NIH under award R00MH109626 (to S.F.) and by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (Z01 ES100221 to S.M.D.). | en |
| dc.identifier.doi | https://doi.org/10.1016/j.celrep.2019.08.093 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/97087 | en |
| dc.identifier.volume | 29 | en |
| dc.language.iso | en_US | en |
| dc.publisher | CellPress | en |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
| dc.title | Hippocampal Subregions Express Distinct Dendritic Transcriptomes that Reveal Differences in Mitochondrial Function in CA2 | en |
| dc.title.serial | Cell Reports | en |
| dc.type | Article - Refereed | en |