Age-relevant in vitro models may lead to improved translational research for traumatic brain injury

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dc.contributor.authorDickerson, Michelle R.en
dc.contributor.authorGuilhaume-Correa, Fernandaen
dc.contributor.authorStrickler, Jessicaen
dc.contributor.authorVandeVord, Pamela J.en
dc.date.accessioned2022-12-14T15:31:08Zen
dc.date.available2022-12-14T15:31:08Zen
dc.date.issued2022-06en
dc.description.abstractTraumatic brain injury (TBI) is a major health problem affecting both children and adults. Although TBI studies have been focused on neurons, glial cells play an important role in neuropathology following injury. As the consequences of TBI are age-dependent, it is essential that in vitro and in vivo models are fully representative of clinical outcomes. Traditionally, in vitro models that focused on TBI-induced glial cell dysfunction use primary cells isolated from neonatal rodents, or cell lines. These models are widely used to elucidate molecular pathways affected by the injury; however, they fail to account for age-related differences. As glial characteristics are known to change during maturation, it is important to explore new age-relevant in vitro models leading to improved translation research and advancements in therapeutic strategies for TBI.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.cobme.2022.100391en
dc.identifier.issn2468-4511en
dc.identifier.other100391en
dc.identifier.urihttp://hdl.handle.net/10919/112886en
dc.identifier.volume22en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectTraumatic brain injuryen
dc.subjectAstrocytesen
dc.subjectMicrogliaen
dc.subjectOligodendrocytesen
dc.subjectMagnetic-activated cell sortingen
dc.titleAge-relevant in vitro models may lead to improved translational research for traumatic brain injuryen
dc.title.serialCurrent Opinion in Biomedical Engineeringen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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