Iatrogenic Leptomeningeal Carcinomatosis Following Craniotomy for Resection of Metastatic Serous Ovarian Carcinoma: A Systematic Literature Review and Case Report

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dc.contributor.authorStopa, Brittany M.en
dc.contributor.authorCuoco, Joshua A.en
dc.contributor.authorAdhikari, Srijanen
dc.contributor.authorGrider, Douglas J.en
dc.contributor.authorRogers, Cara M.en
dc.contributor.authorMarvin, Eric A.en
dc.date.accessioned2022-06-30T16:42:32Zen
dc.date.available2022-06-30T16:42:32Zen
dc.date.issued2022-04-25en
dc.description.abstractMetastasis of ovarian carcinoma to the central nervous system occurs in <2% of cases and classically localizes within the brain parenchyma. Moreover, leptomeningeal spread of these tumors is an exceedingly rare phenomenon. Here, we conduct a systematic review of the current literature on the natural history, treatment options, and proposed pathogenic mechanisms of leptomeningeal carcinomatosis in ovarian carcinoma. We also report a case of a 67-year-old female with stage IV metastatic ovarian serous carcinoma initially confined to the peritoneal cavity with a stable disease burden over the course of three years. Follow-up imaging demonstrated an intracranial lesion, which was resected via craniotomy, and pathology was consistent with the original diagnosis. Three months after surgery, she developed rapidly progressive dizziness, generalized weakness, fatigue, and ataxia. Repeat MRI demonstrated interval development of extensive and diffusely enhancing dural nodularity, numerous avidly enhancing supratentorial and infratentorial lesions, enhancement of the bilateral trigeminal nerves, internal auditory canals, and exit wound from the surgical site into the posterior aspect of the right-sided neck musculature consistent with diffuse leptomeningeal dissemination. The present case highlights that leptomeningeal dissemination of ovarian carcinoma is a potential yet rare consequence following surgical resection of an ovarian parenchymal metastasis. Progressive clinical symptomatology that develops postoperatively in this patient population should prompt urgent workup to rule out leptomeningeal disease and an expedited radiation oncology consultation if identified.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fsurg.2022.850050en
dc.identifier.issn2296-875Xen
dc.identifier.other850050en
dc.identifier.pmid35548192en
dc.identifier.urihttp://hdl.handle.net/10919/111068en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectleptomeningeal carcinomatosisen
dc.subjectneoplastic meningitisen
dc.subjectovarian canceren
dc.subjectcraniotomyen
dc.subjectmetastasesen
dc.subjectcase reporten
dc.subjectliterature reviewen
dc.titleIatrogenic Leptomeningeal Carcinomatosis Following Craniotomy for Resection of Metastatic Serous Ovarian Carcinoma: A Systematic Literature Review and Case Reporten
dc.title.serialFrontiers in Surgeryen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Scholarly Works, Virginia Tech Carilion School of Medicine (VTCSOM)
Scholarly Works, School of Neuroscience