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Flagellar Motor Transformed: Biophysical Perspectives of the Myxococcus xanthus Gliding Mechanism

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dc.contributor.authorChen, Jingen
dc.contributor.authorNan, Beiyanen
dc.date.accessioned2022-06-15T14:08:33Zen
dc.date.available2022-06-15T14:08:33Zen
dc.date.issued2022-05-06en
dc.description.abstractMany bacteria move on solid surfaces using gliding motility, without involvement of flagella or pili. Gliding of Myxococcus xanthus is powered by a proton channel homologous to the stators in the bacterial flagellar motor. Instead of being fixed in place and driving the rotation of a circular protein track like the flagellar basal body, the gliding machinery of M. xanthus travels the length of the cell along helical trajectories, while mechanically engaging with the substrate. Such movement entails a different molecular mechanism to generate propulsion on the cell. In this perspective, we will discuss the similarities and differences between the M. xanthus gliding machinery and bacterial flagellar motor, and use biophysical principles to generate hypotheses about the operating mechanism, efficiency, sensitivity to control, and mechanosensing of M. xanthus gliding.en
dc.description.notesFunding National Institutes of Health R35GM138370 to JC and R01GM129000 to BN.en
dc.description.sponsorshipNational Institutes of Health [R35GM138370, R01GM129000]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fmicb.2022.891694en
dc.identifier.eissn1664-302Xen
dc.identifier.other891694en
dc.identifier.pmid35602090en
dc.identifier.urihttp://hdl.handle.net/10919/110784en
dc.identifier.volume13en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectmyxobacteriaen
dc.subjectbacterial motilityen
dc.subjectbacterial glidingen
dc.subjectproton channelen
dc.subjectcell polarityen
dc.subjectmechanosensingen
dc.subjectforce transmissionen
dc.titleFlagellar Motor Transformed: Biophysical Perspectives of the Myxococcus xanthus Gliding Mechanismen
dc.title.serialFrontiers in Microbiologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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