Model Studies of the Dynamics of Bacterial Flagellar Motors

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dc.contributorVirginia Techen
dc.contributor.authorBai, F.en
dc.contributor.authorLo, C. J.en
dc.contributor.authorBerry, R. M.en
dc.contributor.authorXing, Jianhuaen
dc.contributor.departmentBiological Sciencesen
dc.date.accessed2014-02-05en
dc.date.accessioned2014-02-26T19:10:05Zen
dc.date.available2014-02-26T19:10:05Zen
dc.date.issued2009-04en
dc.description.abstractThe bacterial flagellar motor is a rotary molecular machine that rotates the helical filaments that propel swimming bacteria. Extensive experimental and theoretical studies exist on the structure, assembly, energy input, power generation, and switching mechanism of the motor. In a previous article, we explained the general physics underneath the observed torque-speed curves with a simple two-state Fokker-Planck model. Here, we further analyze that model, showing that 1), the model predicts that the two components of the ion motive force can affect the motor dynamics differently, in agreement with latest experiments; 2), with explicit consideration of the stator spring, the model also explains the lack of dependence of the zero-load speed on stator number in the proton motor, as recently observed; and 3), the model reproduces the stepping behavior of the motor even with the existence of the stator springs and predicts the dwell-time distribution. The predicted stepping behavior of motors with two stators is discussed, and we suggest future experimental procedures for verification.en
dc.description.sponsorshipU.S. Department of Energy by the University of Califormen
dc.description.sponsorshipLawrence Livermore National Laboratory W-7405-Eng-48en
dc.description.sponsorshipWellcome Trust VIP researchen
dc.identifier.citationBai, Fan; Lo, Chien-Jung; Berry, Richard M.; et al. "Model Studies of the Dynamics of Bacterial Flagellar Motors," Biophysical Journal 96(8), 3154-3167 (2009); doi: 10.1016/j.bpj.2009.01.023en
dc.identifier.doihttps://doi.org/10.1016/j.bpj.2009.01.023en
dc.identifier.issn0006-3495en
dc.identifier.urihttp://hdl.handle.net/10919/25773en
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0006349509004895en
dc.language.isoen_USen
dc.publisherCELL PRESSen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjecttorque-speed relationshipen
dc.subjectescherichia-colien
dc.subjectrotary motoren
dc.subjectgeneratingen
dc.subjectunitsen
dc.subjectcrystal-structureen
dc.subjectmolecular motoren
dc.subjectdrivenen
dc.subjectrotoren
dc.subjectvibrioen
dc.subjectforceen
dc.titleModel Studies of the Dynamics of Bacterial Flagellar Motorsen
dc.title.serialBiophysical Journalen
dc.typeArticle - Refereeden

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