EvoCor: a platform for predicting functionally related genes using phylogenetic and expression profiles

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dc.contributor.authorDittmar, W. Jamesen
dc.contributor.authorMcIver, Laurenen
dc.contributor.authorMichalak, Pawelen
dc.contributor.authorGarner, Harold R.en
dc.contributor.authorValdez, Gregorioen
dc.contributor.departmentBiological Sciencesen
dc.contributor.departmentFralin Biomedical Research Instituteen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2019-04-12T14:55:19Zen
dc.date.available2019-04-12T14:55:19Zen
dc.date.issued2014-07-01en
dc.description.abstractThe wealth of publicly available gene expression and genomic data provides unique opportunities for computational inference to discover groups of genes that function to control specific cellular processes. Such genes are likely to have co-evolved and be expressed in the same tissues and cells. Unfortunately, the expertise and computational resources required to compare tens of genomes and gene expression data sets make this type of analysis difficult for the average end-user. Here, we describe the implementation of a web server that predicts genes involved in affecting specific cellular processes together with a gene of interest. We termed the server 'EvoCor', to denote that it detects functional relationships among genes through evolutionary analysis and gene expression correlation. This web server integrates profiles of sequence divergence derived by a Hidden Markov Model (HMM) and tissue-wide gene expression patterns to determine putative functional linkages between pairs of genes.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1093/nar/gku442en
dc.identifier.eissn1362-4962en
dc.identifier.issn0305-1048en
dc.identifier.issueW1en
dc.identifier.pmid24848012en
dc.identifier.urihttp://hdl.handle.net/10919/88952en
dc.identifier.volume42en
dc.language.isoen_USen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectr packageen
dc.subjectproteinen
dc.subjectgenomeen
dc.subjectmodelsen
dc.subjectmouseen
dc.titleEvoCor: a platform for predicting functionally related genes using phylogenetic and expression profilesen
dc.title.serialNucleic Acids Researchen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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