Retinal inputs signal astrocytes to recruit interneurons into visual thalamus

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dc.contributor.authorSu, Jianminen
dc.contributor.authorCharalambakis, Naomi E.en
dc.contributor.authorSabbagh, Ubadahen
dc.contributor.authorSomaiya, Rachana D.en
dc.contributor.authorMonavarfeshani, Aboozaren
dc.contributor.authorGuido, Williamen
dc.contributor.authorFox, Michael A.en
dc.contributor.departmentFralin Biomedical Research Instituteen
dc.contributor.departmentBiological Sciencesen
dc.contributor.departmentVirginia Tech Carilion School of Medicineen
dc.date.accessioned2021-01-08T15:19:28Zen
dc.date.available2021-01-08T15:19:28Zen
dc.date.issued2020-02-04en
dc.description.abstractInhibitory interneurons comprise a fraction of the total neurons in the visual thalamus but are essential for sharpening receptive field properties and improving contrast-gain of retinogeniculate transmission. During early development, these interneurons undergo long-range migration from germinal zones, a process regulated by the innervation of the visual thalamus by retinal ganglion cells. Here, using transcriptomic approaches, we identified a motogenic cue, fibroblast growth factor 15 (FGF15), whose expression in the visual thalamus is regulated by retinal input. Targeted deletion of functional FGF15 in mice led to a reduction in thalamic GABAergic interneurons similar to that observed in the absence of retinal input. This loss may be attributed, at least in part, to misrouting of interneurons into nonvisual thalamic nuclei. Unexpectedly, expression analysis revealed that FGF15 is generated by thalamic astrocytes and not retino-recipient neurons. Thus, these data show that retinal inputs signal through astrocytes to direct the long-range recruitment of interneurons into the visual thalamus.en
dc.description.notesWe thank Drs. S. Robel, S. Kliewer, and S. W. Wang for generously supplying Aldh1l1-GFP, Fgf15<SUP>-/-</SUP>, and Math5<SUP>-/-</SUP> mice, respectively; and Barbara O'Steen for her expert technical support. This work was supported by the National Institutes of Health Grants EY021222 (to M.A.F.), EY030568 (to M.A.F.), EY012716 (to W.G.), and NS113459 (to U.S.).en
dc.description.sponsorshipNational Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [EY021222, EY030568, EY012716, NS113459]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1073/pnas.1913053117en
dc.identifier.issn0027-8424en
dc.identifier.issue5en
dc.identifier.pmid31964831en
dc.identifier.urihttp://hdl.handle.net/10919/101792en
dc.identifier.volume117en
dc.language.isoenen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectastrocyteen
dc.subjectthalamusen
dc.subjectinterneuronen
dc.titleRetinal inputs signal astrocytes to recruit interneurons into visual thalamusen
dc.title.serialProceedings of The National Academy of Sciences of The United States of Americaen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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