Electronic Cigarette Vaping Did Not Enhance the Neural Process of Working Memory for Regular Cigarette Smokers

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dc.contributor.authorKim, Dong-Youlen
dc.contributor.authorJang, Yujinen
dc.contributor.authorHeo, Da-Woonen
dc.contributor.authorJo, Sungmanen
dc.contributor.authorKim, Hyun-Chulen
dc.contributor.authorLee, Jong-Hwanen
dc.date.accessioned2022-07-26T15:59:07Zen
dc.date.available2022-07-26T15:59:07Zen
dc.date.issued2022-02-18en
dc.description.abstractBackgroundElectronic cigarettes (e-cigs) as substitute devices for regular tobacco cigarettes (r-cigs) have been increasing in recent times. We investigated neuronal substrates of vaping e-cigs and smoking r-cigs from r-cig smokers. MethodsTwenty-two r-cig smokers made two visits following overnight smoking cessation. Functional magnetic resonance imaging (fMRI) data were acquired while participants watched smoking images. Participants were then allowed to smoke either an e-cig or r-cig until satiated and fMRI data were acquired. Their craving levels and performance on the Montreal Imaging Stress Task and a 3-back alphabet/digit recognition task were obtained and analyzed using two-way repeated-measures analysis of variance. Regions-of-interest (ROIs) were identified by comparing the abstained and satiated conditions. Neuronal activation within ROIs was regressed on the craving and behavioral data separately. ResultsCraving was more substantially reduced by smoking r-cigs than by vaping e-cigs. The response time (RT) for the 3-back task was significantly shorter following smoking r-cigs than following vaping e-cigs (interaction: F (1, 17) = 5.3, p = 0.035). Neuronal activations of the right vermis (r = 0.43, p = 0.037, CI = [-0.05, 0.74]), right caudate (r = 0.51, p = 0.015, CI = [0.05, 0.79]), and right superior frontal gyrus (r = -0.70, p = 0.001, CI = [-0.88, -0.34]) were significantly correlated with the RT for the 3-back task only for smoking r-cigs. ConclusionOur findings suggest that insufficient satiety from vaping e-cigs for r-cigs smokers may be insignificant effect on working memory function.en
dc.description.notesThis work was supported by the grants from the National Research Foundation (NRF) and MSIP of Korea (2015R1A2A2A03004462, 2016M3C7A1914450, 2017R1E1A1A01077288, and 2021M3E5D2A01022515), and in part by a National Research Council of Science & Technology (NST) grant from the Korean government (MSIT) (No. CAP-18-01-KIST).en
dc.description.sponsorshipNational Research Foundation (NRF); MSIP of Korea [2015R1A2A2A03004462, 2016M3C7A1914450, 2017R1E1A1A01077288, 2021M3E5D2A01022515]; National Research Council of Science & Technology (NST) grant from the Korean government (MSIT) [CAP-18-01-KIST]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fnhum.2022.817538en
dc.identifier.issn1662-5161en
dc.identifier.other817538en
dc.identifier.pmid35250518en
dc.identifier.urihttp://hdl.handle.net/10919/111372en
dc.identifier.volume16en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectabstinenceen
dc.subjectelectronic cigaretteen
dc.subjecttobacco cigarettesen
dc.subjectfunctional magnetic resonance imagingen
dc.subjectsatietyen
dc.subjectworking memoryen
dc.titleElectronic Cigarette Vaping Did Not Enhance the Neural Process of Working Memory for Regular Cigarette Smokersen
dc.title.serialFrontiers in Human Neuroscienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Scholarly Works, Fralin Biomedical Research Institute at VTC
Destination Area: Adaptive Brain and Behavior (ABB)