Time-keeping and decision-making in the cell cycle

dc.contributor.authorTyson, John J.en
dc.contributor.authorNovak, Belaen
dc.date.accessioned2022-12-01T14:30:15Zen
dc.date.available2022-12-01T14:30:15Zen
dc.date.issued2022-06-10en
dc.description.abstractCell growth, DNA replication, mitosis and division are the fundamental processes by which life is passed on from one generation of eukaryotic cells to the next. The eukaryotic cell cycle is intrinsically a periodic process but not so much a 'clock' as a 'copy machine', making new daughter cells as warranted. Cells growing under ideal conditions divide with clock-like regularity; however, if they are challenged with DNA-damaging agents or mitotic spindle disrupters, they will not progress to the next stage of the cycle until the damage is repaired. These 'decisions' (to exit and re-enter the cell cycle) are essential to maintain the integrity of the genome from generation to generation. A crucial challenge for molecular cell biologists in the 1990s was to unravel the genetic and biochemical mechanisms of cell cycle control in eukaryotes. Central to this effort were biochemical studies of the clock-like regulation of 'mitosis promoting factor' during synchronous mitotic cycles of fertilized frog eggs and genetic studies of the switch-like regulation of 'cyclin-dependent kinases' in yeast cells. In this review, we uncover some secrets of cell cycle regulation by mathematical modelling of increasingly more complex molecular regulatory networks of cell cycle 'clocks' and 'switches'.en
dc.description.notesWe acknowledge financial support from BBSRC Strategic LoLa grant BB/M00354X/1en
dc.description.sponsorshipBBSRC Strategic LoLa grant [BB/M00354X/1]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1098/rsfs.2021.0075en
dc.identifier.eissn2042-8901en
dc.identifier.issn2042-8898en
dc.identifier.issue4en
dc.identifier.other20210075en
dc.identifier.pmid35860005en
dc.identifier.urihttp://hdl.handle.net/10919/112759en
dc.identifier.volume12en
dc.language.isoenen
dc.publisherRoyal Societyen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectcell cycle regulationen
dc.subjectcell cycle checkpointsen
dc.subjectcyclin-dependent kinasesen
dc.subjectmathematical modelsen
dc.subjectlimit cyclesen
dc.subjectbistable switchesen
dc.titleTime-keeping and decision-making in the cell cycleen
dc.title.serialInterface Focusen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
rsfs.2021.0075.pdf
Size:
2.32 MB
Format:
Adobe Portable Document Format
Description:
Published version