Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis

Simple item page
dc.contributor.authorLuo, Yantingen
dc.contributor.authorLu, Xuemeien
dc.contributor.authorXie, Hehuang Daviden
dc.contributor.departmentBiological Sciencesen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2017-09-18T09:41:19Zen
dc.date.available2017-09-18T09:41:19Zen
dc.date.issued2014-08-27en
dc.date.updated2017-09-18T09:41:19Zen
dc.description.abstractDNA methylation primarily occurs on CpG dinucleotides and plays an important role in transcriptional regulations during tissue development and cell differentiation. Over 25% of CpG dinucleotides in the human genome reside within Alu elements, the most abundant human repeats. The methylation of Alu elements is an important mechanism to suppress Alu transcription and subsequent retrotransposition. Decades of studies revealed that Alu methylation is highly dynamic during early development and aging. Recently, many environmental factors were shown to have a great impact on Alu methylation. In addition, aberrant Alu methylation has been documented to be an early event in many tumors and Alu methylation levels have been associated with tumor aggressiveness. The assessment of the Alu methylation has become an important approach for early diagnosis and/or prognosis of cancer. This review focuses on the dynamic Alu methylation during development, aging, and tumor genesis. The cause and consequence of Alu methylation changes will be discussed.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationYanting Luo, Xuemei Lu, and Hehuang Xie, “Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis,” BioMed Research International, vol. 2014, Article ID 784706, 12 pages, 2014. doi:10.1155/2014/784706en
dc.identifier.doihttps://doi.org/10.1155/2014/784706en
dc.identifier.urihttp://hdl.handle.net/10919/78958en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2014 Yanting Luo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleDynamic Alu Methylation during Normal Development, Aging, and Tumorigenesisen
dc.title.serialBioMed Research Internationalen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 2 of 2
Name:
BMRI.2014.784706.xml
Size:
7.32 KB
Format:
Extensible Markup Language
Download
Thumbnail Image
Name:
BMRI.2014.784706.pdf
Size:
814.06 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.5 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Journal Articles, Hindawi Press
Scholarly Works, Biological Sciences
Scholarly Works, Fralin Life Sciences Institute