All Faculty Deposits

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The "All Faculty Deposits" collection contains works deposited by faculty and appointed delegates from the Elements (EFARs) system. For help with Elements, see Frequently Asked Questions on the Provost's website. In general, items can only be deposited if the item is a scholarly article that is covered by Virginia Tech's open access policy, or the item is openly licensed or in the public domain, or the item is permitted to be posted online under the journal/publisher policy, or the depositor owns the copyright. See Right to Deposit on the VTechWorks Help page. If you have questions email us at vtechworks@vt.edu.

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Now showing 1 - 9 of 9

Child and Adolescent Health From 1990 to 2015: Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2015 Study
Global Burden of Disease Child and Adolescent Health Collaboration; Kassebaum, N.; Kyu, H. H.; Zoeckler, L.; Olsen, H. E.; Thomas, K.; Pinho, C.; Bhutta, Z. A.; Dandona, L.; Ferrari, A.; Ghiwot, T. T.; Hay, Simon I.; Kinfu, Y.; Liang, X.; Lopez, A.; Malta, D. C.; Mokdad, Ali H.; Naghavi, Mohsen; Patton, G. C.; Salomon, J.; Sartorius, Benn; Topor-Madry, Roman; Vollset, S. E.; Werdecker, Andrea; Whiteford, H. A.; Abate, K. H.; Abbas, Kaja M.; Abreha Damtew, S.; Ahmed, M. B.; Akseer, N.; Al-Raddadi, Rajaa; Alemayohu, M. A.; Altirkawi, Khalid A.; Abajobir, A. A.; Amare, A. T.; Antonio, C. A.; Arnlov, J.; Artaman, A.; Asayesh, Hamid; Avokpaho, E. F.; Awasthi, A.; Ayala Quintanilla, B. P.; Bacha, Umar; Balem, D.; Barac, A.; Bärnighausen, T. W.; Baye, E.; Bedi, N.; Bensenor, I. M.; Berhane, Adugnaw; Bernabe, E.; Bernal, O. A.; Beyene, A. S.; Biadgilign, S.; Bikbov, B.; Boyce, C. A.; Brazinova, A.; Hailu, G. B.; Carter, Austin; Castañeda-Orjuela, Carlos A.; Catalá-López, F.; Charlson, F. J.; Chitheer, A. A.; Choi, J. J.; Ciobanu, L. G.; Crump, J.; Dandona, R.; Dellavalle, R. P.; Deribew, Amare; deVeber, G.; Dicker, D.; Betsu, B. B.; Ding, E. L.; Dubey, M.; Endries, A. Y.; Erskine, H. E.; Faraon, E. J.; Faro, A.; Farzadfar, F.; Fernandes, J. C.; Fijabi, D. O.; Fitzmaurice, C.; Fleming, T. D.; Flor, L. S.; Foreman, Kyle J.; Franklin, R. C.; Fraser, M. S.; Frostad, J. J.; Fullman, N.; Gebregergs, G. B.; Gebru, A. A.; Geleijnse, J. M.; Gibney, K. B.; Gidey Yihdego, M.; Ginawi, I. A.; Gishu, Melkamu Dedefo; Gizachew, T. A.; Glaser, E.; Gold, A. L.; Goldberg, E.; Gona, P.; Goto, A.; Gugnani, H. C.; Jiang, G.; Gupta, Rahul; Tesfay, F. H.; Hankey, G. J.; Havmoeller, R.; Hijar, M.; Horino, M.; Hosgood, H. D.; Hu, G.; Jacobsen, K. H.; Jakovljevic, M. B.; Jayaraman, S. P.; Jha, V.; Jibat, Tariku; Johnson, Catherine O.; Jonas, Jost; Kasaeian, Amir; Kawakami, Norito; Keiyoro, P. N.; Khalil, Ibrahim; Khang, Y. H.; Khubchandani, Jagdish; Ahmad Kiadaliri, A. A.; Kieling, C.; Kim, D.; Kissoon, Niranjan; Knibbs, L. D.; Koyanagi, Ai; Krohn, K. J.; Kuate Defo, B.; Kucuk Bicer, B.; Kulikoff, R.; Kumar, G. A.; Lal, D. K.; Lam, H. Y.; Larson, Heidi J.; Larsson, A.; Laryea, D. O.; Leung, J.; Lim, S. S.; Lo, L. T.; Lo, W. D.; Looker, K. J.; Lotufo, P. A.; Magdy Abd, H.; El Razek; Malekzadeh, Reza; Markos Shifti, D.; Mazidi, M.; Meaney, P. A.; Meles, K. G.; Memiah, Peter; Mendoza, Walter; Abera Mengistie, M.; Mengistu, G. W.; Mensah, G. A.; Miller, Ted R.; Mock, C.; Mohammadi, A.; Mohammed, S.; Monasta, L.; Mueller, U.; Nagata, C.; Naheed, A.; Nguyen, G.; Nguyen, Q. L.; Nsoesie, E.; Oh, I. H.; Okoro, A.; Olusanya, J. O.; Olusanya, B. O.; Ortiz, A.; Paudel, D.; Pereira, David M.; Perico, N.; Petzold, M.; Phillips, M. R.; Polanczyk, G. V.; Pourmalek, Farshad; Qorbani, Mostafa; Rafay, Anwar; Rahimi-Movaghar, Vafa; Rahman, M.; Rai, R. K.; Ram, U.; Rankin, Z.; Remuzzi, G.; Renzaho, Andre M. N.; Roba, H. S.; Rojas-Rueda, D.; Ronfani, L.; Sagar, R.; Sanabria, J. R.; Kedir Mohammed, M. S.; Santos, I. S.; Satpathy, M.; Sawhney, M.; Schöttker, B.; Schwebel, D. C.; Scott, J. G.; Sepanlou, Sadaf G.; Shaheen, A.; Shaikh, M. A.; She, J.; Shiri, R.; Shiue, I.; Sigfusdottir, I. D.; Singh, J.; Slipakit, N.; Smith, A.; Sreeramareddy, C.; Stanaway, J. D.; Stein, D. J.; Steiner, C.; Sufiyan, M. B.; Swaminathan, S.; Tabarés-Seisdedos, R.; Tabb, K. M.; Tadese, F.; Tavakkoli, M.; Taye, B.; Teeple, S.; Tegegne, T. K.; Temam Shifa, G.; Terkawi, A. S.; Thomas, B.; Thomson, A. J.; Tobe-Gai, R.; Tonelli, Marcello; Tran, Bach Xuan; Troeger, Christopher; Ukwaja, Kingsley N.; Uthman, Olalekan; Vasankari, Tommi; Venketasubramanian, Narayanaswamy; Vlassov, Vasiliy Victorovich; Weiderpass, Elisabete; Weintraub, Robert; Gebrehiwot, Solomon Weldemariam; Westerman, Ronny; Williams, Hywel C.; Wolfe, Charles D. A.; Woodbrook, Rachel; Yano, Yuichiro; Yonemoto, Naohiro; Yoon, Seok-Jun; Younis, Mustafa Z.; Yu, Chuanhua; Zaki, Maysaa El Sayed; Zegeye, Elias Asfaw; Zuhlke, Liesl Joanna; Murray, Christopher J. L.; Vos, Theo (2017-04-03)
Importance: Comprehensive and timely monitoring of disease burden in all age groups, including children and adolescents, is essential for improving population health. Objective: To quantify and describe levels and trends of mortality and nonfatal health outcomes among children and adolescents from 1990 to 2015 to provide a framework for policy discussion. Evidence Review: Cause-specific mortality and nonfatal health outcomes were analyzed for 195 countries and territories by age group, sex, and year from 1990 to 2015 using standardized approaches for data processing and statistical modeling, with subsequent analysis of the findings to describe levels and trends across geography and time among children and adolescents 19 years or younger. A composite indicator of income, education, and fertility was developed (Socio-demographic Index [SDI]) for each geographic unit and year, which evaluates the historical association between SDI and health loss. Findings: Global child and adolescent mortality decreased from 14.18 million (95% uncertainty interval [UI], 14.09 million to 14.28 million) deaths in 1990 to 7.26 million (95% UI, 7.14 million to 7.39 million) deaths in 2015, but progress has been unevenly distributed. Countries with a lower SDI had a larger proportion of mortality burden (75%) in 2015 than was the case in 1990 (61%). Most deaths in 2015 occurred in South Asia and sub-Saharan Africa. Global trends were driven by reductions in mortality owing to infectious, nutritional, and neonatal disorders, which in the aggregate led to a relative increase in the importance of noncommunicable diseases and injuries in explaining global disease burden. The absolute burden of disability in children and adolescents increased 4.3% (95% UI, 3.1%-5.6%) from 1990 to 2015, with much of the increase owing to population growth and improved survival for children and adolescents to older ages. Other than infectious conditions, many top causes of disability are associated with long-term sequelae of conditions present at birth (eg, neonatal disorders, congenital birth defects, and hemoglobinopathies) and complications of a variety of infections and nutritional deficiencies. Anemia, developmental intellectual disability, hearing loss, epilepsy, and vision loss are important contributors to childhood disability that can arise from multiple causes. Maternal and reproductive health remains a key cause of disease burden in adolescent females, especially in lower-SDI countries. In low-SDI countries, mortality is the primary driver of health loss for children and adolescents, whereas disability predominates in higher-SDI locations; the specific pattern of epidemiological transition varies across diseases and injuries. Conclusions and Relevance: Consistent international attention and investment have led to sustained improvements in causes of health loss among children and adolescents in many countries, although progress has been uneven. The persistence of infectious diseases in some countries, coupled with ongoing epidemiologic transition to injuries and noncommunicable diseases, require all countries to carefully evaluate and implement appropriate strategies to maximize the health of their children and adolescents and for the international community to carefully consider which elements of child and adolescent health should be monitored.
Clinical Response, Outbreak Investigation and Epidemiology of the Fungal Meningitis Epidemic in the United States: Systematic Review
Abbas, Kaja M.; Dorratoltaj, Nargesalsadat; O'Dell, Margaret L.; Bordwine, Paige; Kerkering, Thomas M.; Redican, Kerry J. (2016-10-01)
We conducted a systematic review of the 2012-2013 multistate fungal meningitis epidemic in the United States from the perspectives of clinical response, outbreak investigation, and epidemiology. Articles focused on clinical response, outbreak investigation, and epidemiology were included, whereas articles focused on compounding pharmacies, legislation and litigation, diagnostics, microbiology, and pathogenesis were excluded. We reviewed 19 articles by use of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) framework. The source of the fungal meningitis outbreak was traced to the New England Compounding Center in Massachusetts, where injectable methylprednisolone acetate products were contaminated with the predominant pathogen, Exserohilum rostratum. As of October 23, 2013, the final case count stood at 751 patients and 64 deaths, and no additional cases are anticipated. The multisectoral public health response to the fungal meningitis epidemic from the hospitals, clinics, pharmacies, and the public health system at the local, state, and federal levels led to an efficient epidemiological investigation to trace the outbreak source and rapid implementation of multiple response plans. This systematic review reaffirms the effective execution of a multisectoral public health response and efficient delivery of the core functions of public health assessment, policy development, and service assurances to improve population health.
Editorial Comment: Cost-Effectiveness Analysis for Prioritization of Limited Public Health Resources - Tuberculosis Interventions in Texas
Abbas, Kaja M. (2014)
Public health departments have limited evidence to understand and analyze the costs and benefits of different health programs, including tuberculosis control and prevention programs. The study by Miller et. al addresses this challenge to estimate costs and benefits of tuberculosis prevention programs in Texas and identify cost-effective diagnostic and treatment combinations, thereby improving the evidence-based decision making power of the public health departments.
Epidemiological Modeling of Bovine Brucellosis in India
Kang, Gloria J.; Gunaseelan, L.; Abbas, Kaja M. (IEEE, 2014-01-01)
Facilitators and barriers of parental attitudes and beliefs toward school-located influenza vaccination in the United States: Systematic review
Kang, Gloria J.; Culp, Rachel K.; Abbas, Kaja M. (2017-04-11)
The study objective was to identify facilitators and barriers of parental attitudes and beliefs toward school-located influenza vaccination in the United States. In 2009, the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention expanded their recommendations for influenza vaccination to include school-aged children. We conducted a systematic review of studies focused on facilitators and barriers of parental attitudes toward school-located influenza vaccination in the United States from 1990 to 2016. We reviewed 11 articles by use of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) framework. Facilitators were free/low cost vaccination; having belief in vaccine efficacy, influenza severity, and susceptibility; belief that vaccination is beneficial, important, and a social norm; perception of school setting advantages; trust; and parental presence. Barriers were cost; concerns regarding vaccine safety, efficacy, equipment sterility, and adverse effects; perception of school setting barriers; negative physician advice of contraindications; distrust in vaccines and school-located vaccination programs; and health information privacy concerns. We identified the facilitators and barriers of parental attitudes and beliefs toward school-located influenza vaccination to assist in the evidence-based design and implementation of influenza vaccination programs targeted for children in the United States and to improve influenza vaccination coverage for population-wide health benefits.
Rethinking health systems strengthening: key systems thinking tools and strategies for transformational change
Swanson, R. Chad; Cattaneo, Aadriano; Bradley, Elizabeth; Chunharas, Somsak; Atun, Rifat; Abbas, Kaja M.; Katsaliaki, Korina; Mustafee, Navonil; Mason Meier, Benjamin; Best, Allan (Oxford University Press, 2012-10-01)
While reaching consensus on future plans to address current global health challenges is far from easy, there is broad agreement that reductionist approaches that suggest a limited set of targeted interventions to improve health around the world are inadequate. We argue that a comprehensive systems perspective should guide health practice, education, research and policy. We propose key ‘systems thinking’ tools and strategies that have the potential for transformational change in health systems. Three overarching themes span these tools and strategies: collaboration across disciplines, sectors and organizations; ongoing, iterative learning; and transformational leadership. The proposed tools and strategies in this paper can be applied, in varying degrees, to every organization within health systems, from families and communities to national ministries of health. While our categorization is necessarily incomplete, this initial effort will provide a valuable contribution to the health systems strengthening debate, as the need for a more systemic, rigorous perspective in health has never been greater.
Role of bacille Calmette-Guérin in preventing tuberculous infection
Adinarayanan, S.; Culp, Rachel K.; Subramani, R.; Abbas, Kaja M.; Radhakrishna, S.; Swaminathan, S. (2017-04-01)
SETTING: Rural community in South India. OBJECTIVE: To determine the role of bacille Calmette-Guérin (BCG) in preventing tuberculous infection in children. DESIGN: A prevalence survey was undertaken in 1999-2001 in a representative rural population in Tiruvallur District in South India using cluster sampling. Tuberculin testing was performed among all children aged <15 years, and all adults aged 15 years were questioned about chest symptoms and underwent radiography, followed by sputum examinations, if indicated. RESULTS: In children living in households with a tuberculosis case, the proportion with evidence of tuberculous infection was 35.5% of 200 in the absence of a BCG scar and 27.0% of 100 in its presence, a reduction of 24% (P = 0.14). In very young children (age <5 years), the corresponding proportions were 29.1% of 55 and 11.9% of 42, a reduction of 59%; the difference was statistically significant (P = 0.048). CONCLUSION: There is a possible role for BCG in preventing tuberculous infection in very young children.
Spatial Big Data Analytics of Influenza Epidemic in Vellore, India
Lopez, Daphne; Gunasekaran, M.; Murugan, B. Senthil; Kaur, Harpreet; Abbas, Kaja M. (IEEE, 2014-01-01)
The study objective is to develop a big spatial data model to predict the epidemiological impact of influenza in Vellore, India. Large repositories of geospatial and health data provide vital statistics on surveillance and epidemiological metrics, and valuable insight into the spatiotemporal determinants of disease and health. The integration of these big data sources and analytics to assess risk factors and geospatial vulnerability can assist to develop effective prevention and control strategies for influenza epidemics and optimize allocation of limited public health resources. We used the spatial epidemiology data of the HIN1 epidemic collected at the National Informatics Center during 2009-2010 in Vellore. We developed an ecological niche model based on geographically weighted regression for predicting influenza epidemics in Vellore, India during 2013-2014. Data on rainfall, temperature, wind speed, humidity and population are included in the geographically weighted regression analysis. We inferred positive correlations for H1N1 influenza prevalence with rainfall and wind speed, and negative correlations for H1N1 influenza prevalence with temperature and humidity. We evaluated the results of the geographically weighted regression model in predicting the spatial distribution of the influenza epidemic during 2013-2014.
Studies in Big Data Series: Internet of Things and Big Data Technologies for Next Generation Healthcare
Abbas, Kaja M.; Manogaran, Gunasekaran; Thota, Chandu; Lopez, Daphne; Vijayakumar, V.; Sundarsekar, Revathi (2017)
The health care systems are rapidly adopting large amounts of data, driven by record keeping, compliance and regulatory requirements, and patient care. The advances in healthcare system will rapidly enlarge the size of the health records that are accessible electronically. Concurrently, fast progress has been made in clinical analytics. For example, new techniques for analyzing large size of data and gleaning new business insights from that analysis is part of what is known as big data. Big data also hold the promise of supporting a wide range of medical and healthcare functions, including among others disease surveillance, clinical decision support and population health management. Hence, effective big data based knowledge management system is needed for monitoring of patients and identify the clinical decisions to the doctor. The chapter proposes a big data based knowledge management system to develop the clinical decisions. The proposed knowledge system is developed based on variety of databases such as Electronic Health Record (EHR), Medical Imaging Data, Unstructured Clinical Notes and Genetic Data. The proposed methodology asynchronously communicates with different data sources and produces many alternative decisions to the doctor.

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