Scholarly Works, Mechanical Engineering

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https://hdl.handle.net/10919/23262
Research articles, presentations, and other scholarship

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Browsing Scholarly Works, Mechanical Engineering by Department "Biological Systems Engineering"

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    Drone-Based Community Assessment, Planning, and Disaster Risk Management for Sustainable Development
    Whitehurst, Daniel; Friedman, Brianna; Kochersberger, Kevin B.; Sridhar, Venkataramana; Weeks, James (MDPI, 2021-04-30)
    Accessible, low-cost technologies and tools are needed in the developing world to support community planning, disaster risk assessment, and land tenure. Enterprise-scale geographic information system (GIS) software and high-resolution aerial or satellite imagery are tools which are typically not available to or affordable for resource-limited communities. In this paper, we present a concept of aerial data collection, 3D cadastre modeling, and disaster risk assessment using low-cost drones and adapted open-source software. Computer vision/machine learning methods are used to create a classified 3D cadastre that contextualizes and quantifies potential natural disaster risk to existing or planned infrastructure. Building type and integrity are determined from aerial imagery. Potential flood damage risk to a building is evaluated as a function of three mechanisms: undermining (erosion) of the foundation, hydraulic pressure damage, and building collapse due to water load. Use of Soil and Water Assessment Tool (SWAT) provides water runoff estimates that are improved using classified land features (urban ecology, erosion marks) to improve flow direction estimates. A convolutional neural network (CNN) is trained to find these flood-induced erosion marks from high-resolution drone imagery. A flood damage potential metric scaled by property value estimates results in individual and community property risk assessments.
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    The impact of sphingosine kinase inhibitor-loaded nanoparticles on bioelectrical and biomechanical properties of cancer cells
    Babahosseini, Hesam; Srinivasaraghavan, Vaishnavi; Zhao, Zongmin; Gillam, Francis; Childress, Elizabeth; Strobl, Jeannine S.; Santos, Webster L.; Zhang, Chenming; Agah, Masoud (The Royal Society of Chemistry, 2015-11-19)
    Cancer progression and physiological changes within the cells are accompanied by alterations in the biophysical properties. Therefore, the cell biophysical properties can serve as promising markers for cancer detection and physiological activities. To aid in the investigation of the biophysical markers of cells, a microfluidic chip has been developed which consists of a constriction channel and embedded microelectrodes. Single-cell impedance magnitudes at four frequencies and entry and travel times are measured simultaneously during their transit through the constriction channel. This microchip provides a high-throughput, label-free, automated assay to identify biophysical signatures of malignant cells and monitor the therapeutic efficacy of drugs. Here, we monitored the dynamic cellular biophysical properties in response to sphingosine kinase inhibitors (SphKIs), and compared the effectiveness of drug delivery using poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) loaded with SphKIs versus conventional delivery. Cells treated with SphKIs showed significantly higher impedance magnitudes at all four frequencies. The bioelectrical parameters extracted using a model also revealed that the highly aggressive breast cells treated with SphKIs shifted electrically towards that of a less malignant phenotype; SphKI-treated cells exhibited an increase in cell-channel interface resistance and a significant decrease in specific membrane capacitance. Furthermore, SphKI-treated cells became slightly more deformable as measured by a decrease in their channel entry and travel times. We observed no significant difference in the bioelectrical changes produced by SphKI delivered conventionally or with NPs. However, NPs-packaged delivery of SphKI decreased the cell deformability. In summary, this study showed that while the bioelectrical properties of the cells were dominantly affected by SphKIs, the biomechanical properties were mainly changed by the NPs.