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- 13C-Metabolic Flux Analysis: An Accurate Approach to Demystify Microbial Metabolism for Biochemical ProductionGuo, Weihua; Sheng, Jiayuan; Feng, Xueyang (MDPI, 2015-12-25)Metabolic engineering of various industrial microorganisms to produce chemicals, fuels, and drugs has raised interest since it is environmentally friendly, sustainable, and independent of nonrenewable resources. However, microbial metabolism is so complex that only a few metabolic engineering efforts have been able to achieve a satisfactory yield, titer or productivity of the target chemicals for industrial commercialization. In order to overcome this challenge, 13C Metabolic Flux Analysis (13C-MFA) has been continuously developed and widely applied to rigorously investigate cell metabolism and quantify the carbon flux distribution in central metabolic pathways. In the past decade, many 13C-MFA studies have been performed in academic labs and biotechnology industries to pinpoint key issues related to microbe-based chemical production. Insightful information about the metabolic rewiring has been provided to guide the development of the appropriate metabolic engineering strategies for improving the biochemical production. In this review, we will introduce the basics of 13C-MFA and illustrate how 13C-MFA has been applied via integration with metabolic engineering to identify and tackle the rate-limiting steps in biochemical production for various host microorganisms
- The 2019 Conference on Health and Active Transportation: Research Needs and OpportunitiesBerrigan, David; Dannenberg, Andrew L.; Lee, Michelle; Rodgers, Kelly; Wojcik, Janet R.; Wali, Behram; Tribby, Calvin P.; Buehler, Ralph; Sallis, James F.; Roberts, Jennifer D.; Steedly, Ann; Peng, Binbin; Eisenberg, Yochai; Rodriguez, Daniel A. (MDPI, 2021-11-11)Active transportation (AT) is widely viewed as an important target for increasing participation in aerobic physical activity and improving health, while simultaneously addressing pollution and climate change through reductions in motor vehicular emissions. In recent years, progress in increasing AT has stalled in some countries and, furthermore, the coronavirus (COVID-19) pandemic has created new AT opportunities while also exposing the barriers and health inequities related to AT for some populations. This paper describes the results of the December 2019 Conference on Health and Active Transportation (CHAT) which brought together leaders from the transportation and health disciplines. Attendees charted a course for the future around three themes: Reflecting on Innovative Practices, Building Strategic Institutional Relationships, and Identifying Research Needs and Opportunities. This paper focuses on conclusions of the Research Needs and Opportunities theme. We present a conceptual model derived from the conference sessions that considers how economic and systems analysis, evaluation of emerging technologies and policies, efforts to address inclusivity, disparities and equity along with renewed attention to messaging and communication could contribute to overcoming barriers to development and use of AT infrastructure. Specific research gaps concerning these themes are presented. We further discuss the relevance of these themes considering the pandemic. Renewed efforts at research, dissemination and implementation are needed to achieve the potential health and environmental benefits of AT and to preserve positive changes associated with the pandemic while mitigating negative ones.
- 2nd Workshop on Multimodal Motion Sickness Detection and Mitigation Methods for Car Journeys - Finding Consensus in the FieldPöhlmann, Katharina; Al-Taie, Ammar; Li, Gang; Dam, Abhraneil; Wang, Yu-Kai; Wei, Chun-Shu; Papaioannou, Georgios (ACM, 2023-09-18)The adoption of automated vehicles will be a positive step towards road safety and environmental benefits. However, one major challenge that still exist is motion sickness. The move from drivers to passengers who will engage in non-driving related tasks as well as the potential change in the layout of the car interior that will come with automated vehicles are expected to result in a worsened experience of motion sickness. The previous workshop [18] highlighted the need for consensus on guidelines regarding study design for motion sickness research. Hence, this workshop will develop a guide for motion sickness research through reflection and discussions on the current methodologies used by experts in the field. Further it will build on the knowledge collected from the previous workshop and will thereby facilitate not only new research ideas and fruitful collaborations but also find a consensus in the field in regard to study design and methodologies.
- 2nd Workshop on Uncertainty Reasoning and Quantification in Decision MakingZhao, Xujiang; Zhao, Chen; Chen, Feng; Cho, Jin-Hee; Chen, Haifeng (ACM, 2023-08-06)Uncertainty reasoning and quantification play a critical role in decision making across various domains, prompting increased attention from both academia and industry. As real-world applications become more complex and data-driven, effectively handling uncertainty becomes paramount for accurate and reliable decision making. This workshop focuses on the critical topics of uncertainty reasoning and quantification in decision making. It provides a platform for experts and researchers from diverse backgrounds to exchange ideas on cutting-edge techniques and challenges in this field. The interdisciplinary nature of uncertainty reasoning and quantification, spanning artificial intelligence, machine learning, statistics, risk analysis, and decision science, will be explored. The workshop aims to address the need for robust and interpretable methods for modeling and quantifying uncertainty, fostering reasoning decision-making in various domains. Participants will have the opportunity to share research findings and practical experiences, promoting collaboration and advancing decision-making practices under uncertainty.
- A 52-Year-Old HIV-Positive Man with Abdominal PainMehmood, Tashfeen; Chua, Matt J.; Khasawneh, Faisal A. (Hindawi, 2015-01-01)
- 5th International Symposium on Focused UltrasoundAbounader, Roger; Abraham, Christopher; Adema, Gosse; Agrawal, Punit; Airan, Raag; Aleman, Dionne; Alexander, Phillip; Alkins, Ryan; Alnazeer, Moez; Altman, Michael; Aly, Amirah; Amaral, Joao G.; Amrahli, Maral; Amraoui, Sana; Andarawewa, Kumari; Andriyakhina, Yulia; Angstadt, Mary; Ankou, Bénédicte; Arias, Ana C.; Arvanitis, Costas; Asadnia, Kiana; Aubert, Isabelle; Aubry, Jean-Francois; Aubry, Jean-Francois; Aurup, Christian; Bader, Kenneth; Badr, Lena; Baek, Hongchae; Barbato, Gaetano; Beccaria, Kevin; Bellorofonte, Carlo; Benson, Lee; Bernus, Olivier; Berriet, Rémi; Bertolina, Jim; Beskin, Viktoriya; Bessière, Francis; Bethune, Allison; Bezzi, Mario; Bond, Aaron; Bonomo, Guido; Borowsky, Alexander; Borys, Nicolas; Böttcher, Joachim; Bouley, Donna; Bour, Pierre; Bourekas, Eric; Brenin, David; Brokman, Omer; Brosh, Inbar; Buckner, Andrew; Bullock, Timothy; Cafarelli, Andrea; Cahill, Jessica; Camarena, Francisco; Camelo-Piragua, Sandra; Campbell, Benjamin; Campbell, Fiona; Cannata, Jon; Canney, Michael; Carlson, Roy; Carneiro, Antonio; Carpentier, Alexandre; Catheline, Stefan; Cavin, Ian; Cesana, Claudio; Chabok, Hamid R.; Chamanara, Marzieh; Chang, Jin H.; Chang, Won S.; Changizi, Barbara; Chapelon, Jean Y.; Chaplin, Vandiver; Chapman, Martin; Chaudhary, Neeraj; Chaussy, Christian; Chen, Cherry; Chen, Johnny; Chen, Wohsing; Chen, Xiaoming; Chevalier, Philippe; Chiou, George; Chisholm, Alexander; Christofferson, Ivy; Chung, Hyun H.; Ciuti, Gastone; Clement, Gregory; Cooper, Mark; Corea, Joseph; Corso, Cristiano; Cosman, Josh; Coughlin, Dezba; Crake, Calum; Cunitz, Bryan; Curiel, Laura; Curley, Colleen T.; Czarnota, Gregory; Dababou, Susan; Dallapiazza, Robert; de Bever, Joshua; de Jager, Bram; de Ruiter, Joost; de Senneville, Baudouin D.; Deckers, Roel; Delattre, Jean-Yves; den Brok, Martijn; Dhanaliwala, Ali; Diodato, Alessandro; Dixon, Adam; Donner, Elizabeth; Downs, Matthew; Du, Zhongmin; Dubois, Rémi; Dupre, Aurelien; Eikelenboom, Dylan; Elias, W. J.; Ellens, Nicholas; Endre, Ruby; Eran, Ayelet; Erasmus, Hans-Peter; Everstine, Ashli; Farahani, Keyvan; Farrer, Alexis; Farry, Justin; Federau, Christian; Feng, Xue; Ferrer, Cyril; Ferrera, Vincent; Fishman, Paul; Foley, Jessica; Frenkel, Victor; Fütterer, Jurgen; Gach, H. M.; Gandhi, Dheeraj; Gertner, Michael; Goldsher, Dorit; Gorgone, Alessandro; Greillier, Paul; Griesenauer, Rebekah; Grissom, William; Grondin, Julien; Guha, Chandan; Gulati, Amitabh; Gullapalli, Rao; Guo, Sijia; Gupta, Samit; Gurm, Hitinder; Gwinn, Ryder; Hadley, Rock; Haïssaguerre, Michel; Hammoud, Dima; Hananel, Arik; Hargrove, Amelia; Hatch, Robert; Haworth, Kevin; Hazan, Eilon; He, Ye; Heemels, Maurice; Heerschap, Arend; Hilas, Elaine; Hoang-Xuan, Khe; Hocini, Mélèze; Hodaie, Mojgan; Hofmann, Denis; Holland, Christy; Hoogenboom, Martijn; Hopyan, Sevan; Hossack, John; Houdouin, Alexandre; Hsu, Po-Hung; Hu, Jim; Hurwitz, Mark; Huss, Diane; Hwang, Chang-il; Hwang, Joo H.; Idbaih, Ahmed; Ikeuchi, Masahiko; Ingham, Elizabeth; Ives, Kimberly; Izumi, Masashi; Jackson-Lewis, Vernice; Janát-Amsbury, Margit; Jang, Kee W.; Jedruszczuk, Kathleen; Jiménez-Gambín, Sergio; Jiménez, Noé; Johnson, Sara; Jonathan, Sumeeth; Joy, Joyce; Jung, Hyun H.; Jung, Na Y.; Kahn, Itamar; Kamimura, Hermes; Kamrava, Seyed K.; Kang, Jeeun; Kang, Kook J.; Kang, Soo Y.; Kao, Yi-tzu; Katti, Prateek; Kawasaki, Motohiro; Kaye, Elena; Keupp, Jochen; Kim, AeRang; Kim, Harry; Kim, Hyun-Chul; Kim, Hyuncheol; Kim, Hyungmin; Kim, Min S.; Kim, Namho; Kiyasu, Katsuhito; Kneepkens, Esther; Knopp, Michael; Kobus, Thiele; Koral, Korgun; Kreider, Wayne; Krishna, Vibhor; Krug, Roland; Krupa, Steve; Kuo, Chia-Chun; Kwiecinski, Wojciech; Lacoste, Romain; Lam, Heather; Lamberti-Pasculli, Maria; Lang, Brian; Larner, James; Larrabee, Zachary; Leach, J. K.; LeBlang, Suzanne; Leclercq, Delphine; Lee, Hak J.; Lee, Jong-Hwan; Lehericy, Stéphane; Leighton, Wan; Leung, Steven; Lewis, Bobbi; Lewis, Matthew; Li, Dawei; Linn, Sabine; Lipsman, Nir; Liu, Hao-Li; Liu, Jingfei; Lopes, M. B.; Lotz, Jeff; Lu, Xin; Lundt, Jonathan; Luo, Xi; Lustgarten, Lior; Lustig, Micheal; Macoskey, Jonathan; Madore, Bruno; Maev, Roman; Magat, Julie; Maimbourg, Guillaume; Maimon, Noam; Mainprize, Todd; Malayer, Jerry; Maples, Danny; Marquet, Fabrice; Marrocchio, Cristina; Marx, Mike; Mastorakos, Panagiotis; Mauri, Giovanni; McLean, Hailey; McMichael, John; Mead, Brian P.; Melodelima, David; Melot-Dusseau, Sandrine; Menciassi, Arianna; Merrill, Robb; Meyer, Joshua; Midiri, Massimo; Miga, Michael; Migliore, Ilaria G.; Miller, Eric; Minalga, Emilee; Moon, Hyungwon; Moore, David; Mourad, Pierre; Mouratidis, Petros; Mueller, Michael; Mugler, John; Muller, Sébastien; Namba, Hirofumi; Naor, Omer; Nassar, Maria; Nazai, Navid; Negron, Karina; Negussie, Ayele; Nguyen, Thai-Son; Nicolay, Klaas; Nikolaeva, Anastasia V.; Oetgen, Matthew; Olive, Kenneth; Olumolade, Oluyemi; Orsi, Franco; Owens, Gabe; Ozilgen, Arda; Padegimas, Linas; Palermo, Carmine; Pan, Chia-Hsin; Pandey, Aditya; Papadakis, Georgios; Park, Chang K.; Park, Sang M.; Parker, Jonathon; Parvizi, Mohammad H.; Pascal-Tenorio, Aurea; Patel, Janish; Patz, Sam; Payen, Thomas; Perich, Eloi; Pernot, Mathieu; Perol, David; Perry, James; Pillarisetty, Venu; Pioche, Mathieu; Pizzuto, Matthew; Plaksin, Michael; Plata, Juan; Price, Karl; Prince, Jessica; Przedborski, Serge; Quinones-Hinojosa, Alfredo; Ramachandran, Akhilesh; Ranjan, Ashish; Ravikumar, Vinod; Reichenbach, Juergen; Repasky, Elizabeth; Rezai, Ali; Ritter, Philippe; Rivoire, Michel; Rochman, Carrie; Rosenberg, Jarrett; Rosnitskiy, Pavel B.; Ruiz, Antonio; Sahgal, Arjun; Samiotaki, Gesthimani; Sanghvi, Narendra; Santin, Mathieu D.; Santos, Domiciano; Sasaki, Noboru; Sastra, Steve; Schade, George; Schall, Jeffrey; Schlesinger, Ilana; Schmitt, Paul; Schwaab, Julia; Scionti, Stephen; Scipione, Roberto; Scoarughi, Gian L.; Scott, Serena; Sebeke, Lukas; Seifabadi, Reza; Seo, Jai; Sesenoglu-Laird, Ozge; Shah, Binit; Shahriari, Kian; Shaikh, Sumbul; Shea, Jill; Shi, Jiaqi; Shim, Jenny; Shinkov, Alexander; Shuman, Jillian; Silvestrini, Matthew; Sim, Changbeom; Sin, Vivian; Sinai, Alon; Singh, Manoj; Sinilshchikov, Ilya; Skalina, Karin; Slingluff, Craig; So, Po-Wah; Solomon, Stephen; Son, Keon H.; Sperling, Scott; Stein, Ruben; Stein, Sherman; Stevens, Aaron; Stimec, Jennifer; Storm, Gert; Straube, William; Suelmann, Britt; Sutton, Jonathan; Svedin, Bryant; Takemasa, Ryuichi; Takiguchi, Mitsuyoshi; Tam, Emily; Tan, Jeremy; Tang, Xinyan; Tanter, Mickael; Tebebi, Pamela; Tehrani, Seruz; Temple, Michael; Teofilovic, Dejan; ter Haar, Gail; Terzi, Marina E.; Thueroff, Stefan; Timbie, Kelsie; Tognarelli, Selene; Tretbar, Steffen; Trudeau, Maureen; Tsai, Yi-Chieh; Tsysar, Sergey A.; Tucci, Samantha; Tuveson, David; Ushida, Takahiro; Vaessen, Paul; Vaillant, Fanny; Van Arsdell, Glen; van Breugel, Johanna; Van der Jeugd, Anneke; Van der Jeugd, Anneke; Van der Wall, Elsken; van Diest, Paul; van Stralen, Marijn; Varano, Gianluca; Velat, Manuela; Vidal-Jove, Joan; Vigna, Paolo D.; Vignot, Alexandre; Vincenot, Jeremy; Vykhodtseva, Natalia; Wang, Bin; Wang, Han; Wang, Kevin; Wang, Qi; Wang, Qingguo; Wang, Shengping; Wang, Yak-Nam; Wang, Zhaorui; Wardlow, Rachel; Warren, Amy; Waszczak, Barbara; Watson, Katherine; Webb, Taylor; Wei-Bin, Shen; Wei, Kuo-Chen; Weiss, Steffen; Weissler, Yoni; Werner, Beat; Wesseling, Pieter; Williams, Noelle; Wilson, Emmanuel; Wintermark, Max; Witkamp, Arjen; Wong, Carlos; Wu, Jing-Fu; Wydra, Adrian; Xu, Alexis; Xu, Doudou; Xu, Su; Yang, Georgiana; Yang, Nai-Yi; Yao, Chen; Yarowsky, Paul; Ye, Patrick P.; Yuldashev, Petr; Zaaroor, Menashe; Zachiu, Cornel; Zahos, Peter; Zangos, Stephan; Zhang, Dandan; Zhang, Hua; Zhang, Jimin; Zhang, Junhai; Zhang, Xi; Zhao, Li; Zhong, Pei; Zhuo, Jiachen; Zidowitz, Stephan; Zinke, Wolf; Zorgani, Ali (2016-11-21)
- 6G Enabled Smart Infrastructure for Sustainable Society: Opportunities, Challenges, and Research RoadmapImoize, Agbotiname Lucky; Adedeji, Oluwadara; Tandiya, Nistha; Shetty, Sachin (MDPI, 2021-03-02)The 5G wireless communication network is currently faced with the challenge of limited data speed exacerbated by the proliferation of billions of data-intensive applications. To address this problem, researchers are developing cutting-edge technologies for the envisioned 6G wireless communication standards to satisfy the escalating wireless services demands. Though some of the candidate technologies in the 5G standards will apply to 6G wireless networks, key disruptive technologies that will guarantee the desired quality of physical experience to achieve ubiquitous wireless connectivity are expected in 6G. This article first provides a foundational background on the evolution of different wireless communication standards to have a proper insight into the vision and requirements of 6G. Second, we provide a panoramic view of the enabling technologies proposed to facilitate 6G and introduce emerging 6G applications such as multi-sensory–extended reality, digital replica, and more. Next, the technology-driven challenges, social, psychological, health and commercialization issues posed to actualizing 6G, and the probable solutions to tackle these challenges are discussed extensively. Additionally, we present new use cases of the 6G technology in agriculture, education, media and entertainment, logistics and transportation, and tourism. Furthermore, we discuss the multi-faceted communication capabilities of 6G that will contribute significantly to global sustainability and how 6G will bring about a dramatic change in the business arena. Finally, we highlight the research trends, open research issues, and key take-away lessons for future research exploration in 6G wireless communication.
- A Camelid-Derived STAT-Specific Nanobody Inhibits Neuroinflammation and Ameliorates Experimental Autoimmune Encephalomyelitis (EAE)Mbanefo, Evaristus C.; Seifert, Allison; Yadav, Manoj Kumar; Yu, Cheng-Rong; Nagarajan, Vijayaraj; Parihar, Ashutosh; Singh, Sunanda; Egwuagu, Charles E. (MDPI, 2024-06-16)Proinflammatory T-lymphocytes recruited into the brain and spinal cord mediate multiple sclerosis (MS) and currently there is no cure for MS. IFN-γ-producing Th1 cells induce ascending paralysis in the spinal cord while IL-17-producing Th17 cells mediate cerebellar ataxia. STAT1 and STAT3 are required for Th1 and Th17 development, respectively, and the simultaneous targeting of STAT1 and STAT3 pathways is therefore a potential therapeutic strategy for suppressing disease in the spinal cord and brain. However, the pharmacological targeting of STAT1 and STAT3 presents significant challenges because of their intracellular localization. We have developed a STAT-specific single-domain nanobody (SBT-100) derived from camelids that targets conserved residues in Src homolog 2 (SH2) domains of STAT1 and STAT3. This study investigated whether SBT-100 could suppress experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. We show that SBT-100 ameliorates encephalomyelitis through suppressing the expansion of Th17 and Th1 cells in the brain and spinal cord. Adoptive transfer experiments revealed that lymphocytes from SBT-100-treated EAE mice have reduced capacity to induce EAE, indicating that the immunosuppressive effects derived from the direct suppression of encephalitogenic T-cells. The small size of SBT-100 makes this STAT-specific nanobody a promising immunotherapy for CNS autoimmune diseases, including multiple sclerosis.
- A Review of Bioactive Compound Effects from Primary Legume Protein Sources in Human and Animal HealthShea, Zachary; Ogando do Granja, Matheus; Fletcher, Elizabeth B.; Zheng, Yaojie; Bewick, Patrick; Wang, Zhibo; Singer, William M.; Zhang, Bo (MDPI, 2024-05-01)The global demand for sustainable and nutritious food sources has catalyzed interest in legumes, known for their rich repertoire of health-promoting compounds. This review delves into the diverse array of bioactive peptides, protein subunits, isoflavones, antinutritional factors, and saponins found in the primary legume protein sources—soybeans, peas, chickpeas, and mung beans. The current state of research on these compounds is critically evaluated, with an emphasis on the potential health benefits, ranging from antioxidant and anticancer properties to the management of chronic diseases such as diabetes and hypertension. The extensively studied soybean is highlighted and the relatively unexplored potential of other legumes is also included, pointing to a significant, underutilized resource for developing health-enhancing foods. The review advocates for future interdisciplinary research to further unravel the mechanisms of action of these bioactive compounds and to explore their synergistic effects. The ultimate goal is to leverage the full spectrum of benefits offered by legumes, not only to advance human health but also to contribute to the sustainability of food systems. By providing a comprehensive overview of the nutraceutical potential of legumes, this manuscript sets a foundation for future investigations aimed at optimizing the use of legumes in the global pursuit of health and nutritional security.
- Aberrant placental immune parameters in the feline immunodeficiency virus (FIV)-infected cat suggest virus-induced changes in T cell functionChumbley, Lyndon B.; Boudreaux, Crystal E.; Coats, Karen S. (2013-07-19)Background Immune activity during pregnancy must be tightly regulated to ensure successful pregnancy. This regulation includes the suppression of inflammatory activity that could target the semi-allogeneic fetus. Tregs are immunosuppressive; Th17 cells are pro-inflammatory. A precise balance in the two cell populations is critical to pregnancy maintenance, while dysregulation in this balance accompanies compromised pregnancy in humans and mice. FIV is known to target Tregs preferentially in the infected cat. Therefore, it may be hypothesized that FIV infection alters the placental Treg/Th17 cell balance resulting in aberrant immunomodulator expression by these cells and consequent pregnancy perturbation. Methods RNA was purified from random sections of whole placental tissues collected from both uninfected and FIV-infected queens at early pregnancy, including tissues from viable and nonviable fetuses. Real time qPCR was performed to quantify expression of intranuclear markers of Tregs (FoxP3) and Th17 cells (RORΩ); cytokine products of Tregs (IL-10 and TGF-β), Th17 cells (IL-2, IL-6, and IL-17a), and macrophages (IL-1β); and the FIV gag gene. Pairwise comparisons were made to evaluate coexpression patterns between the cytokines and between the cytokines and the virus. Results Both FoxP3 and RORΩ were reduced in placentas of infected animals. Neither infection status nor fetal viability affected placental expression of IL-1β. However, fetal nonviability was associated with reduced levels of all other cytokines. Infection and fetal nonviability impacted coexpression of various cytokine pairs. No obvious bias toward Treg or Th17 cells was observed. Conclusions FIV infection coupled with fetal nonviability alters expression patterns of T cell cytokines. These data suggest that functionally altered placental T cell leukocyte populations may occur in the infected queen and possibly contribute to fetal nonviability.
- Ablation outcome of irreversible electroporation on potato monitored by impedance spectrum under multi-electrode systemZhao, Yajun; Liu, Hongmei; Bhonsle, Suyashree P.; Wang, Yilin; Davalos, Rafael V.; Yao, Chenguo (2018-09-20)Background Irreversible electroporation (IRE) therapy relies on pulsed electric fields to non-thermally ablate cancerous tissue. Methods for evaluating IRE ablation in situ are critical to assessing treatment outcome. Analyzing changes in tissue impedance caused by electroporation has been proposed as a method for quantifying IRE ablation. In this paper, we assess the hypothesis that irreversible electroporation ablation outcome can be monitored using the impedance change measured by the electrode pairs not in use, getting more information about the ablation size in different directions. Methods Using a square four-electrode configuration, the two diagonal electrodes were used to electroporate potato tissue. Next, the impedance changes, before and after treatment, were measured from different electrode pairs and the impedance information was extracted by fitting the data to an equivalent circuit model. Finally, we correlated the change of impedance from various electrode pairs to the ablation geometry through the use of fitted functions; then these functions were used to predict the ablation size and compared to the numerical simulation results. Results The change in impedance from the electrodes used to apply pulses is larger and has higher deviation than the other electrode pairs. The ablation size and the change in resistance in the circuit model correlate with various linear functions. The coefficients of determination for the three functions are 0.8121, 0.8188 and 0.8691, respectively, showing satisfactory agreement. The functions can well predict the ablation size under different pulse numbers, and in some directions it did even better than the numerical simulation method, which used different electric field thresholds for different pulse numbers. Conclusions The relative change in tissue impedance measured from the non-energized electrodes can be used to assess ablation size during treatment with IRE according to linear functions.
- Ablative and Immunostimulatory Effects of Histotripsy Ablation in a Murine Osteosarcoma ModelHay, Alayna N.; Imran, Khan Mohammad; Hendricks-Wenger, Alissa; Gannon, Jessica M.; Sereno, Jacqueline; Simon, Alex; Lopez, Victor A.; Coutermarsh-Ott, Sheryl; Vlaisavljevich, Eli; Allen, Irving C.; Tuohy, Joanne L. (MDPI, 2023-10-09)Background: Osteosarcoma (OS) is the most frequently occurring malignant bone tumor in humans, primarily affecting children and adolescents. Significant advancements in treatment options for OS have not occurred in the last several decades, and the prognosis remains grim with only a 70% rate of 5-year survival. The objective of this study was to investigate the focused ultrasound technique of histotripsy as a novel, noninvasive treatment option for OS. Methods: We utilized a heterotopic OS murine model to establish the feasibility of ablating OS tumors with histotripsy in a preclinical setting. We investigated the local immune response within the tumor microenvironment (TME) via immune cell phenotyping and gene expression analysis. Findings: We established the feasibility of ablating heterotopic OS tumors with ablation characterized microscopically by loss of cellular architecture in targeted regions of tumors. We observed greater populations of macrophages and dendritic cells within treated tumors and the upregulation of immune activating genes 72 h after histotripsy ablation. Interpretation: This study was the first to investigate histotripsy ablation for OS in a preclinical murine model, with results suggesting local immunomodulation within the TME. Our results support the continued investigation of histotripsy as a novel noninvasive treatment option for OS patients to improve clinical outcomes and patient prognosis.
- Above- and Below-Ground Carbon Sequestration in Shelterbelt Trees in Canada: A ReviewMayrinck, Rafaella C.; Laroque, Colin P.; Amichev, Beyhan Y.; Van Rees, Ken (MDPI, 2019-10-19)Shelterbelts have been planted around the world for many reasons. Recently, due to increasing awareness of climate change risks, shelterbelt agroforestry systems have received special attention because of the environmental services they provide, including their greenhouse gas (GHG) mitigation potential. This paper aims to discuss shelterbelt history in Canada, and the environmental benefits they provide, focusing on carbon sequestration potential, above- and below-ground. Shelterbelt establishment in Canada dates back to more than a century ago, when their main use was protecting the soil, farm infrastructure and livestock from the elements. As minimal-and no-till systems have become more prevalent among agricultural producers, soil has been less exposed and less vulnerable to wind erosion, so the practice of planting and maintaining shelterbelts has declined in recent decades. In addition, as farm equipment has grown in size to meet the demands of larger landowners, shelterbelts are being removed to increase efficiency and machine maneuverability in the field. This trend of shelterbelt removal prevents shelterbelt’s climate change mitigation potential to be fully achieved. For example, in the last century, shelterbelts have sequestered 4.85 Tg C in Saskatchewan. To increase our understanding of carbon sequestration by shelterbelts, in 2013, the Government of Canada launched the Agricultural Greenhouse Gases Program (AGGP). In five years, 27 million dollars were spent supporting technologies and practices to mitigate GHG release on agricultural land, including understanding shelterbelt carbon sequestration and to encourage planting on farms. All these topics are further explained in this paper as an attempt to inform and promote shelterbelts as a climate change mitigation tool on agricultural lands.
- Abstracts from the 3rd Conference on Aneuploidy and Cancer: Clinical and Experimental AspectsCornish-Bowden, Athel; Rasnick, David; Heng, Henry H.; Horne, Steven; Abdallah, Batoul; Liu, Guo; Ye, Christine J.; Bloomfield, Mathew; Vincent, Mark D.; Aldaz, C. M.; Karlsson, Jenny; Valind, Anders; Jansson, Caroline; Gisselsson, David; Graves, Jennifer A. M.; Stepanenko, Aleksei A.; Andreieva, Svitlana V.; Korets, Kateryna V.; Mykytenko, Dmytro O.; Huleyuk, Nataliya L.; Baklaushev, Vladimir P.; Kovaleva, Oksana A.; Chekhonin, Vladimir P.; Vassetzky, Yegor S.; Avdieiev, Stanislav S.; Bakker, Bjorn; Taudt, Aaron S.; Belderbos, Mirjam E.; Porubsky, David; Spierings, Diana C. J.; de Jong, Tristan V.; Halsema, Nancy; Kazemier, Hinke G.; Hoekstra-Wakker, Karina; Bradley, Allan; de Bont, Eveline S. J. M.; van den Berg, Anke; Guryev, Victor; Lansdorp, Peter M.; Tatché, Maria C.; Foijer, Floris; Liehr, Thomas; Baudoin, Nicolaas C.; Nicholson, Joshua M.; Soto, Kimberly; Quintanilla, Isabel; Camps, Jordi; Cimini, Daniela; Dürrbaum, M.; Donnelly, N.; Passerini, V.; Kruse, C.; Habermann, B.; Storchová, Z.; Mandrioli, Daniele; Belpoggi, Fiorella; Silbergeld, Ellen K.; Perry, Melissa J.; Skotheim, Rolf I.; Løvf, Marthe; Johannessen, Bjarne; Hoff, Andreas M.; Zhao, Sen; SveeStrømme, Jonas M.; Sveen, Anita; Lothe, Ragnhild A.; Hehlmann, R.; Voskanyan, A.; Fabarius, A.; Böcking, Alfred; Biesterfeld, Stefan; Berynskyy, Leonid; Börgermann, Christof; Engers, Rainer; Dietz, Josef; Fritz, A.; Sehgal, N.; Vecerova, J.; Stojkovicz, B.; Ding, H.; Page, N.; Tye, C.; Bhattacharya, S.; Xu, J.; Stein, G.; Stein, J.; Berezney, R.; Gong, Xue; Grasedieck, Sarah; Swoboda, Julian; Rücker, Frank G.; Bullinger, Lars; Pollack, Jonathan R.; Roumelioti, Fani-Marlen; Chiourea, Maria; Raftopoulou, Christina; Gagos, Sarantis; Duesberg, Peter; Bloomfield, Mathew; Hwang, Sunyoung; Gustafsson, Hans T.; O’Sullivan, Ciara; Acevedo-Colina, Aracelli; Huang, Xinhe; Klose, Christian; Schevchenko, Andrej; Dickson, Robert C.; Cavaliere, Paola; Dephoure, Noah; Torres, Eduardo M.; Stampfer, Martha R.; Vrba, Lukas; LaBarge, Mark A.; Futscher, Bernard; Garbe, James C.; Trinh, Andrew L.; Zhou, Yi-Hong; Digman, Michelle (2017-06-22)
- Academic Preparedness as a Predictor of Achievement in an Engineering Design ChallengeMentzer, Nathan; Becker, Kurt H. (Council on Technology Teacher Education and the International Technology and Engineering Educators Association, 2010)
- Acceleration Feedback-Based Active and Semi-Active Seismic Response Control of Rail-Counterweight Systems of ElevatorsSingh, Rildova; Singh, Mahendra P. (Hindawi, 2005-01-01)Based on the observations in the past earthquake events, the traction elevators in buildings are known to be vulnerable to earthquake induced ground motions. Among several components of an elevator, the counterweight being heaviest is also known to be more susceptible than others. The inertial effects of the counterweight can overstress the guide rails on which it moves. Here we investigate to use the well-known acceleration feedback-based active and semi-active control methods to reduce stresses in the rails. The only way a control action can be applied to a moving counterweight-rail system is through a mass damper placed in the plane of the counterweight. For this, a part of the counterweight mass can be configured as a mass damper attached to a small actuator for an active scheme or to a magneto-rheological damper for a semi-active scheme. A comprehensive numerical study is conducted to evaluate the effectiveness of the proposed configuration of control system. It is observed that the two control schemes are effective in reducing the stress response by about 20 to 25% and improve the system fragility over a good range of seismic intensities.
- Accelerometer Based Method for Tire Load and Slip Angle EstimationSingh, Kanwar Bharat; Taheri, Saied (MDPI, 2019-04-28)Tire mounted sensors are emerging as a promising technology, capable of providing information about important tire states. This paper presents a survey of the state-of-the-art in the field of smart tire technology, with a special focus on the different signal processing techniques proposed by researchers to estimate the tire load and slip angle using tire mounted accelerometers. Next, details about the research activities undertaken as part of this study to develop a smart tire are presented. Finally, novel algorithms for estimating the tire load and slip angle are presented. Experimental results demonstrate the effectiveness of the proposed algorithms.
- Accepted Tutorials at The Web Conference 2022Tommasini, Riccardo; Basu Roy, Senjuti; Wang, Xuan; Wang, Hongwei; Ji, Heng; Han, Jiawei; Nakov, Preslav; Da San Martino, Giovanni; Alam, Firoj; Schedl, Markus; Lex, Elisabeth; Bharadwaj, Akash; Cormode, Graham; Dojchinovski, Milan; Forberg, Jan; Frey, Johannes; Bonte, Pieter; Balduini, Marco; Belcao, Matteo; Della Valle, Emanuele; Yu, Junliang; Yin, Hongzhi; Chen, Tong; Liu, Haochen; Wang, Yiqi; Fan, Wenqi; Liu, Xiaorui; Dacon, Jamell; Lye, Lingjuan; Tang, Jiliang; Gionis, Aristides; Neumann, Stefan; Ordozgoiti, Bruno; Razniewski, Simon; Arnaout, Hiba; Ghosh, Shrestha; Suchanek, Fabian; Wu, Lingfei; Chen, Yu; Li, Yunyao; Liu, Bang; Ilievski, Filip; Garijo, Daniel; Chalupsky, Hans; Szekely, Pedro; Kanellos, Ilias; Sacharidis, Dimitris; Vergoulis, Thanasis; Choudhary, Nurendra; Rao, Nikhil; Subbian, Karthik; Sengamedu, Srinivasan; Reddy, Chandan; Victor, Friedhelm; Haslhofer, Bernhard; Katsogiannis- Meimarakis, George; Koutrika, Georgia; Jin, Shengmin; Koutra, Danai; Zafarani, Reza; Tsvetkov, Yulia; Balachandran, Vidhisha; Kumar, Sachin; Zhao, Xiangyu; Chen, Bo; Guo, Huifeng; Wang, Yejing; Tang, Ruiming; Zhang, Yang; Wang, Wenjie; Wu, Peng; Feng, Fuli; He, Xiangnan (ACM, 2022-04-25)This paper summarizes the content of the 20 tutorials that have been given at The Web Conference 2022: 85% of these tutorials are lecture style, and 15% of these are hands on.
- Accession-Level Differentiation of Urushiol Levels, and Identification of Cardanols in Nascent Emerged Poison Ivy SeedlingsLott, Aneirin A.; Baklajian, Emily R.; Dickinson, Christopher C.; Collakova, Eva; Jelesko, John G. (MDPI, 2019-11-20)Poison ivy (Toxicodendron radicans (L.) Kuntze) shows accession-level differentiation in a variety of morphometric traits, suggesting local adaptation. To investigate whether the presumed defense compound urushiol also demonstrates accession-level accumulation differences, in vitro nascent germinated poison ivy seedlings from geographically isolated populations were germinated in vitro and then assayed for known urushiol congener accumulation levels. Significant accession-level differences in the accumulation levels of total C15- and C17-, total C15-, total C17-, specific C15 congeners, and specific C17 congeners of urushiol were identified. In addition, hereto novel C15- and C17-urushiol isomers were identified as well. Cardanols are assumed to be the penultimate metabolites giving rise to urushiols, but this assumption was not previously empirically validated. C15-cardanol congeners and isomers corresponding to expected substrates needed to produce the observed C15-urushiol congeners and isomers were identified in the same poison ivy seedling extracts. Total C15-cardanol and C15-cardanol congeners also showed significant accession-level differences. Based on the observed C15-cardanol congeners in poison ivy, the penultimate step in urushiol biosynthesis was proposed to be a cardanol-specific hydroxylase activity.
- Accuracy Improvement of Vehicle Recognition by Using Smart Device SensorsPias, Tanmoy Sarkar; Eisenberg, David; Fresneda Fernandez, Jorge (MDPI, 2022-06-10)This paper explores the utilization of smart device sensors for the purpose of vehicle recognition. Currently a ubiquitous aspect of people’s lives, smart devices can conveniently record details about walking, biking, jogging, and stepping, including physiological data, via often built-in phone activity recognition processes. This paper examines research on intelligent transportation systems to uncover how smart device sensor data may be used for vehicle recognition research, and fit within its growing body of literature. Here, we use the accelerometer and gyroscope, which can be commonly found in a smart phone, to detect the class of a vehicle. We collected data from cars, buses, trains, and bikes using a smartphone, and we designed a 1D CNN model leveraging the residual connection for vehicle recognition. The model achieved more than 98% accuracy in prediction. Moreover, we also provide future research directions based on our study.