Open Access Subvention Fund Articles

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Works in this collection were funded by the Open Access Subvention Fund. See our guide for more about the OASF, including instructions on how to apply.

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Pulmonary and Critical Care Fellowship Program Directors’ Perspective on the Virtual Interview Process
Acharya, Roshan; Peterson, Christopher J.; Foroozesh, Mahtab B. (American Thoracic Society, 2023-09)
Background: Since the start of the coronavirus disease (COVID-19) pandemic, the residency and fellowship recruitment process has changed significantly with the use of virtual interview (VI) platforms. Pulmonary and critical care medicine (PCCM) candidates reported in a survey that VIs hindered their ability to evaluate their fit within the program. However, the program directors’ (PDs’) opinion of this process remains unknown. Objective: We aim to provide insight into the PCCM fellowship PDs’ perspective regarding the virtual recruitment process since the first class of fellows undergoing this process has now completed 1 year of training. Methods: An anonymous survey was sent to the PDs of PCCM programs participating in the National Resident Matching Program match process in 2020 and 2021. The survey consisted of five sections and 26 closed-ended questions and was distributed via email using the SurveyMonkey platform. The survey was conducted for a total of 6 weeks. A follow-up email to nonrespondents was sent every week. The collected responses were divided into two categories: favoring VIs versus not favoring VIs.A multivariable logistic regression analysis was performed to determine the factors associated with favoring VIs. Results: The survey was sent to 190 email accounts from the Fellowship and Residency Electronic Interactive Database Access System website. Over the course of 6 weeks, 64 respondents participated in the survey, with a response rate of 33.68%. Of 64 respondents, 56 (87.5%) fully completed the survey and 8 (12.5%) partially completed the survey. The final sample size was 59. Thirty-six (61.02%) of the PDs favored VIs for future recruitment, and 23 (38.98%) did not (P,0.001). Ninety-seven percent of PDs who favored VIs versus 72.73% of those who did not perceived the current fellows to fit well in the program (P= 0.007). The multivariable logistic regression analysis showed a trend toward higher odds of favoring VIs if PDs believed they were able to represent the program well virtually (adjusted odds ratio, 6.99; 95% confidence interval, 0.79 – 61.58) and if they found that the current fellows fit the program well (adjusted odds ratio, 7.15; 95% confidence interval, 0.76–66.52); however, these results were not statistically significant. Conclusion: In this survey research, we found that the majority of the PCCM fellowship PDs favored a virtual process for future recruitment.
Isolated Laryngeal Angioedema in a Patient with Long-term ACE Inhibitor Use: A Case Report
Flinn, Carney; Massaro, Inna (University of California Department of Emergency Medicine, 2024-01-23)
Introduction: Angiotensin converting enzyme (ACE) inhibitor-associated angioedema is the most common cause of angioedema seen in the emergency department (ED) and can be associated with a high morbidity. Most cases occur within months of initiation of an ACE inhibitor and are associated with facial and/or oropharyngeal swelling. We present a case of isolated laryngeal edema requiring intubation following 10 years of ACE inhibitor therapy. Case Report: An 82-year-old female, who was on lisinopril therapy for 10 years, presented to the ED with shortness of breath and a sensation that her throat was swelling. She appeared to be in mild respiratory distress and could only speak in one-word sentences. On the physical exam, there was no swelling in the tongue, lips, or face, and the uvula was midline. There was mild posterior pharyngeal edema and swelling noted, but the airway was not visibly obstructed. She was tachypneic and stridor was present. After no improvement with medications, anesthesia successfully intubated her in the operating room. It was deemed a difficult airway secondary to posterior pharyngeal erythema and edema. She was diagnosed with ACE inhibitor-associated angioedema and was extubated four days later. Her lisinopril was discontinued, and she has not had a recurrence of angioedema. Conclusion: ACE inhibitor-induced angioedema commonly presents with facial and oropharyngeal swelling. Its recognition, even years after starting an ACE inhibitor, is necessary to ensure swift and appropriate treatment of potentially life-threatening posterior pharyngeal edema.
Sustainable agriculture and food sovereignty in Haiti: sharing knowledge and shaping understanding of food systems at the University of Fondwa
Joseph, Lesly; Stephenson, Max O., Jr.; Zanotti, Laura; Ricot, Scutt (Frontiers Media, 2023-11-13)
The Association of Peasants of Fondwa (APF), a grassroots organization led by a visionary Haitian Spiritan priest, established the private nonprofit University of Fondwa (UNIF) in Haiti in 2004. The University aims to fill a gap in educational opportunities for rural youth and to develop community leaders able to steward food security, sustainable farm animal husbandry, and small business development. Since the institution’s foundation, University faculty members have explored lowinput sustainable agriculture techniques, which were inspired by strategies shared earlier by Cuban agronomists and adapted to the Fondwa region’s mountainous terrain. While the University has faced and continues to confront many challenges related to its sustainability as an institution, this article describes the processes by which its faculty and students have conducted diagnoses of soils and crop choices, the innovations they have developed and introduced to improve harvest productivity in rural Haiti and, especially, the ways and means by which they have sought to share such (re)thinking of traditional practices with local farmers. We argue that the University of Fondwa faculty’s close collaboration with local farmers and the agricultural techniques they have refined thereby have not only improved food security for the families involved but have also contributed to the creation of social capital in the countryside and enabled participating Haitian farmers to imagine a path toward food sovereignty. In addition, by educating farmers and providing them tools to improve their food production, the University has worked to close the deep inequality gap that exists between urban and rural Haiti.
Developing medical simulations for opioid overdose response training: A qualitative analysis of narratives from responders to overdoses
Edwards, G. Franklin; Mierisch, Cassandra; Mutcheson, Brock; Coleman, Keel; Horn, Kimberly; Parker, Sarah Henrickson (PLOS, 2024-03-28)
Medical simulation offers a controlled environment for studying challenging clinical care situations that are difficult to observe directly. Overdose education and naloxone distribution (OEND) programs aim to train potential rescuers in responding to opioid overdoses, but assessing rescuer performance in real-life situations before emergency medical services arrive is exceedingly complex. There is an opportunity to incorporate individuals with firsthand experience in treating out-of-hospital overdoses into the development of simulation scenarios. Realistic overdose simulations could provide OEND programs with valuable tools to effectively teach hands-on skills and support context-sensitive training regimens. In this research, semi-structured interviews were conducted with 17 individuals experienced in responding to opioid overdoses including emergency department physicians, first responders, OEND program instructors, and peer recovery specialists. Two coders conducted qualitative content analysis using open and axial thematic coding to identify nuances associated with illicit and prescription opioid overdoses. The results are presented as narrative findings complemented by summaries of the frequency of themes across the interviews. Over 20 hours of audio recording were transcribed verbatim and then coded. During the open and axial thematic coding process several primary themes, along with subthemes, were identified, highlighting the distinctions between illicit and prescription opioid overdoses. Distinct contextual details, such as locations, clinical presentations, the environment surrounding the patient, and bystanders’ behavior, were used to create four example simulations of outof- hospital overdoses. The narrative findings in this qualitative study offer context-sensitive information for developing out-of-hospital overdose scenarios applicable to simulation training. These insights can serve as a valuable resource, aiding instructors and researchers in systematically creating evidence-based scenarios for both training and research purposes.
Friendly Kisses Can Be Deadly: Capnocytophaga canimorsus Bacteremia in an Asplenic Patient Exposed to Canine Saliva
Rubio, Christina; Miller, Jared; Zrodlowski,Tomasz; Ie, Susanti (Hindawi, 2023-12-20)
The differential diagnosis for febrile asplenic patients must always include opportunistic infections. Capnocytophaga canimorsus is one such infection. In this report, we discuss the case of a 73-year-old woman with a medical history significant for splenectomy for splenic sarcoma with prophylactic vaccination for pneumococcus who presented with rigors, emesis, and abdominal pain. Initial vital signs were 39.6°C (103.3°F), 166/70 mmHg, 92 bpm, and 95% SpO₂ on room air. A physical examination revealed mild epigastric tenderness. Initial labs and imaging were unremarkable. Eight hours after the presentation, she became hypotensive. Repeat labs revealed leukopenia with 51% bands, hemoglobin 11.0 g/dL down from 13.9 g/dL, platelets 74 K/μL trending down to 15 K/μL, PT 23.5 sec., aPTT 60.3 sec., D-dimer greater than 20 μg/mL, fibrinogen 190 mg/dL, LDH 1515 IU/L, haptoglobin less than 20 mg/dL, and creatinine 1.84 mg/dL. A peripheral smear showed schistocytes. Blood cultures identified gram-negative rods and Capnocytophaga canimorsus. After further questioning, she recalled her dog licking an abrasion on her left index finger. Four days after the presentation, she developed a purpuric rash on her bilateral hands and feet with areas of Nikolsky’s negative bullae along the dorsum of her left foot. She also developed acute renal failure requiring renal replacement therapy and hemodialysis. Capnocytophaga canimorsus is an encapsulated facultative anaerobic gram-negative bacillus. Infection can result in bacteremia and sepsis and carries a high mortality rate, even with treatment. Those with hyposplenism/ asplenia are particularly susceptible to infection and can deteriorate quickly, as seen in this case. Although this infection is rare, our case highlights how all asplenic patients must be assessed and treated for encapsulated bacterial infections when presenting with an acute febrile illness, regardless of initial laboratory analysis.
Solvent recovery from solvent-fine coal slurries by filtration and steam stripping
Huylo, Michael; Huang, Kaiwu; Noble, Aaron; Yoon, Roe-Hoan; Qiao, Rui (Frontiers Media, 2023-08-22)
Dewatering of fine coal is a significant industrial challenge with economic and environmental implications. Due to the lack of suitable dewatering technologies, fine coal particles are often discarded to waste impoundments, leading to substantial loss of valuable natural resources while creating environmental problems. The hydrophobic-hydrophilic separation (HHS) process is a unique solution to this problem. In this process, a recyclable solvent is used to simultaneously remove inorganic impurities (ash) and water from a run-of-mine fine coal slurry. A small amount of recyclable oil (or solvent) is added to a fine coal slurry so that the solvent can spontaneously displace the water from the surface of coal particles. The spent solvent is subsequently recovered and recycled in a closed loop. Here, we report the results obtained using two different solvents, i.e., pentane and hexane, to de-ash and dewater ultrafine coal and recover the spent solvent by filtration, followed by steam stripping. Most of the spent solvent can be recovered during the filtration step at 20 psig N₂ and at a 60 s filtration time. The residual solvent left in the cake was then recovered using steam under different conditions. The results showed that the residual solvent concentration could be reduced to <1,400 ppm after 10 s of steam stripping at 150°C and 15 psig.
Can dialectical behavior therapy skills group treat social anxiety disorder? A brief integrative review
Andino, Mara Villalongo; Garcia, Katelyn M.; Richey, John A. (Frontiers Media, 2024-01-08)
The purposes of this brief integrative review are to identify and critically evaluate recent work in the area of Dialectical Behavior Therapy-Skills Group (DBT-SG) for Social Anxiety Disorder (SAD) with suicidal ideation (SI) and to suggest further how DBT-based skills may be applied to cognitive maintenance factors of SAD. Accordingly, we first evaluate the relevance of DBT in treating SI in other disorders. Second, we evaluate the relationship between SI and SAD, providing considerations for the complexity of comorbid disorders and presentations. Finally, we extend this knowledge to discuss considerations for the use of DBT-SG skills to target specific etiological and maintenance elements of SAD, with a focus on four themes (interpersonal effectiveness, mindfulness, emotion regulation, and distress tolerance). Overall, we conclude that DBT-SG may prove beneficial in reducing SI and symptoms in SAD that impact social and emotional functioning.
Systems mapping of multilevel factors contributing to dental caries in adolescents
Sadjadpour, Fatima; Hosseinichimeh, Niyousha; Pahel, Bhavna T.; Metcalf, Sara S. (Frontiers Media, 2024-01-31)
Dental caries is a prevalent chronic disease among adolescents. Caries activity increases significantly during adolescence due to an increase in susceptible tooth surfaces, immature permanent tooth enamel, independence in pursuing self-care, and a tendency toward poor diet and oral hygiene. Dental caries in permanent teeth is more prevalent among adolescents in low-income families and racial/ethnic minority groups, and these disparities in adolescent dental caries experience have persisted for decades. Several conceptual and datadriven models have proposed unidirectional mechanisms that contribute to the extant disparities in adolescent dental caries experience. Our objective, using a literature review, is to provide an overview of risk factors contributing to adolescent dental caries. Specifically, we map the interactive relationships of multilevel factors that influence dental caries among adolescents. Such interactive multilevel relationships more closely reflect the complex nature of dental caries experience among the adolescent population. The methods that we use are two-fold: (1) a literature review using PubMed and Cochrane databases to find contributing factors; and (2) the system dynamics approach for mapping feedback mechanisms underlying adolescent dental caries through causal loop diagramming. The results of this study, based on the review of 138 articles, identified individual, family and community-level factors and their interactions contributing to dental caries experience in adolescents. Our results also provide hypotheses about the mechanisms underlying persistence of dental caries among adolescents. Conclusions: Our findings may contribute to a deeper understanding of the multilevel and interconnected factors that shape the persistence of dental caries experience among adolescents.
Validating a measure of motivational climate in health science courses
Jones, Brett D.; Wilkins, Jesse L.; Schram, Ásta B.; Gladman, Tehmina; Kenwright, Diane; Lucio-Ramírez, César A. (Springer Nature, 2023-08-02)
Purpose: The aim of the study was to examine the validity evidence for the 19-item form of the MUSIC Model of Academic Motivation Inventory (College Student version) within health science schools in three different countries. The MUSIC Inventory includes five scales that assess the motivational climate by measuring students’ perceptions related to five separate constructs: empowerment, usefulness, success, interest, and caring. Background: The 26-item form of the MUSIC Inventory has been validated for use with undergraduate students and with students in professional schools, including students at a veterinary medicine school, a pharmacy school, and a medical school. A 19-item form of the MUSIC Inventory has also been validated for use with undergraduate students, but it has not yet been validated for use with medical school students. The purpose of this study was to provide validity evidence for the use of the 19-item form in heath science schools in three different countries to determine if this version is acceptable for use in different cultures. If validated, this shorter form of the MUSIC Inventory would provide more differentiation between the Interest and Usefulness scales and could reduce respondent fatigue. Methodology: Cook et al’s practical guidelines were followed to implement Kane’s validity framework as a means to examine the evidence of validity through scoring inferences, generalization inferences, and extrapolation inferences. Students (n = 667) in health science schools within three countries were surveyed. Results: The results produced evidence to support all five hypotheses related to scoring, generalization, and extrapolation inferences. Conclusions: Scores from the 19-item form of the MUSIC Inventory are valid for use in health science courses within professional schools in different countries. Therefore, the MUSIC Inventory can be used in these schools to assess students’ perceptions of the motivational climate.
Problems of knowledge, problems of order: the open science field site
Goldensher, Liora O’Donnell (Frontiers Media, 2023-11-16)
Ethnographers can and should not just do or not do open science, but study the push to share data, instruments, and other research materials as an important moment of change and contest in contemporary knowledge-making and knowledge politics. Following ethnographers of science and technology who have demonstrated the analytic opportunities afforded by moments of scientific controversy, we should treat the places where these calls are made, debated, and taken up as important field sites for ethnographic inquiry. Whenever and wherever the sharing of data, instruments, and research is discussed, planned, done, measured, judged, or regulated, there are powerful claims, visions, and action concerning what makes for facticity, legitimacy, and credibility in both research and politics. From these sites, I argue, we can observe changes to disciplinary and popular understandings of epistemic virtue, or what makes for reliable, factual, or adequately transparent knowledge production. Attention to these sites can also yield important perspectives on the ways that visions of proper research conduct are imbricated with visions of governance. I argue that turning ethnographic methods to studying the open science movement can enable us to do timely scholarship about shifting understandings of facticity, knowledge, information, and governance.
Understanding Teacher Preparation of the Past: The Student Teaching Block in Agricultural Education
Price, Tyler J.; Ferand, Natalie K.; Sewell, Emily A.; Coleman, Bradley M. (Advancements in Agricultural Development, 2023-08-14)
The preparatory experiences leading up to student teaching vary greatly. Understanding the evolution of the student teaching block can provide key guidance on what is needed for the student teacher of today and the student teacher of tomorrow. A historical narrative approach was used to understand the student teaching block as it has been developed and implemented historically in agricultural education. Six semi-structured interviews were conducted with participants who were current faculty at the rank of Professor in agricultural education and had been involved in agricultural education for at least 25 years. Four themes emerged through our analysis: (a) origins, (b) purpose and philosophy, (c) structural elements of the block, and (d) limitations and forward-thinking. Based on the findings, the purpose of the block as it relates to the agricultural education profession is to provide an intensive, immersive experience to prepare soon-to-be student teachers in an environment that provides an opportunity for practice and reflection before entering the classroom. It is recommended that periodic check-ins or seminars with student teachers be done to ensure they can reflect, share experiences, exchange ideas, discuss best practices, and learn from each other as they experience student teaching.
Realtime Detection of PMU Bad Data and Sequential Bad Data Classifications in Cyber-Physical Testbed
Khan, Imtiaj; Centeno, Virgilio (IEEE, 2023-07-18)
Modern Smart Grids incorporate physical power grids and cyber systems, creating a cyberphysical system. Phasor measurement units (PMUs) transmit time synchronized measurement data from physical grid to the cyber system. The System Operator (SO) in the cyber layer analyzes the data in both online and offline format and ensures the reliability and security of the grid by sending necessary command back to the PMUs. However, various physical events such as line to ground faults, frequency events, transformer events as well as cyberattacks can cause deviation in measurements received by the SO, which can be termed as ‘‘bad data’’. These bad data in turn can cause the SO to take a wrong restorative/ mitigating strategy. Therefore accurate detection of bad data and identification of correct bad data type is necessary to ensure grid’s safety and optimal performance. In this work we proposed a realtime sequential bad data detection and bad data classification strategy. At first, we have exploited the low rank property of Hankel-matrix to detect the occurrence of bad data in realtime. Secondly, we classify the bad data into two categories: physical events and cyberattacks. The algorithm utilizes the difference in low rank approximation error of multi-channel Hankel-matrix before and after random column permutations during physical events. If the cause of bad data is identified as cyberattack, our proposed algorithm proceeds to identify the cause of cyberattack. We have considered two possible cyberattack types: false data injection attack (FDIA) and GPS-spoofing attack (GSA). The proposed algorithm observes rank-1 approximation error of single-channel Hankel matrix containing unwrapped phase angle data to distinguish FDIA from GSA. Finally, the proposed algorithm is implemented in a realtime cyber-physical testbed containing PMU simulator and openECA. Results from the testbed using IEEE 13 node test feeder show that by choosing optimum parameters of Hankel-matrix, the bad data can be detected as well as the type of bad data can be correctly identified within less than 1 sec. of the occurrence of physical event or cyberattack. The bad data detection shows 100% accuracy for Hankel-matrix data-window greater than 140. Bad data can be classified as either cyberattack or physical event with perfect accuracy for data-window length greater than 73 for the threshold 0.1. A data-window length between 80 to 120 can distinguish GSA from FDIA, while GSA is implemented with varying phase angle shift of 0.1⁰ to 0.5⁰. The realtime sequential model is also verified with IEEE 118 bus system simulated with SIEMENS PSS/E. Due to more complicated grid structure, IEEE 118 system requires more computational time to identify the bad data type, however that is still less than 2 sec, and can perform detection and classification with data-window length as small as 40.
Flipped Science Fair Invites Children to Judge Graduate Student Posters Through a University-Community Partnership
Lewis, Abigail L.; O’Malley, Grace; Palissery, Gates K.; Hensley, Amanda; Lloreda, Carla López; Perez, Claudia; Bueren, Emma K. (Vanderbilt University Library, 2023-10-03)
Flipped Science Fairs put power directly into children’s hands, inviting them to judge graduate student science fair posters. At the fair, graduate students practice communicating their research to a young audience, while children have the opportunity to see themselves as valued contributors in science. Here, we present a model for a walk-in Flipped Science Fair, designed in partnership between nine Virginia Tech graduate students and the Roanoke City Public Libraries (RPL; Roanoke, VA, USA). At our event, 27 graduate students presented posters about their research, with an audience of over 250 community members. We found that hosting the Flipped Science Fair at a public library lowered barriers to entry for participants and allowed us to reach an audience further from the university. While judging posters, children learned about a wide range of leading-edge research and had meaningful interactions with diverse scientists in small-group settings. Conversely, for graduate students, this event and associated training workshops provided an opportunity to practice communicating their research to a new audience. Throughout this article, we share our experience as graduate students collaboratively conceptualizing and organizing this community-oriented Flipped Science Fair with public library partners.
Bodies and Bites: a medical school program that teaches anatomy, physiology, and nutrition to elementary school kids
Butterfield, Kimberly; Wesley, Mary; Carvalho, Helena; Holt Foerst, Emily; Toy, Serkan; Powell, Courtney; Trinkle, David; Rau, Kristofer (Frontiers, 2024-07-09)
Undergraduate medical students who participate in community outreach programs gain a multitude of benefits that impact not only their professional development but also the well-being of the communities they serve. At the Virginia Tech Carilion School of Medicine (VTCSOM), students have the opportunity to volunteer in the “Bodies and Bites” program at the West End Center for Youth, an after-school educational center that serves K-12 children in Roanoke, Virginia. The purpose of Bodies and Bites is to teach elementary school children in 2nd to 5th grade how their bodies work and how to keep them healthy through good nutrition and exercise. All sessions are led by VTCSOM medical students and graduate students from our partnering academic institution, the Fralin Biomedical Research Institute (FBRI). Each week, the children and Health Professions students explore a different topic related to human anatomy and physiology using anatomical models, small group discussions, and hands-on activities. At the end of each session, the participants create a healthy snack related to the day’s topic. The overall goal of the present study was to assess the perception of the Bodies and Bites program from the view of our student volunteers, and the 4th and 5th graders who attend the West End Center. Now in its 6th year, Bodies and Bites continues to be popular as a voluntary program among our Health Professions students, and is well received by the West End Center and the elementary school children they serve. Our students and community mutually benefit from this program, with the former having an opportunity to briefly disengage from the rigors of their studies while gaining valuable skills in science communication and inspiring children to pursue fields in Science, Technology, Engineering, Math, and Medicine (STEMM), and the latter having fun while learning about their bodies and discovering ways to improve their health.
Effects of a Neuroscience-Based Mindfulness Meditation Program on Psychological Health: Pilot Randomized Controlled Trial
Lynn, Sarah; Basso, Julia C. (JMIR Publications, 2023)
Background: Mindfulness and meditation have a rich historical tradition, and a growing scientific base of evidence supports their use in creating positive psychological and neuroplastic changes for practitioners. Although meditation can be taught in various ways, the scientific community has yet to systematically study the impact of different types of meditation on neuropsychological outcomes, especially as it pertains to digital implementation. Therefore, it is critical that the instruction of mindfulness be evidence based because meditation is being used in both scientific and clinical settings. Objective: This study investigated the use of teacher cueing and the integration of neuroscience education into a meditation program. Compassion cueing was chosen as the element of experimental manipulation because traditional lineages of Buddhist meditation teach compassion for self and others as one of the primary outcomes of meditation. We hypothesized that participants receiving compassion cueing would have enhanced neuropsychological outcomes compared with those receiving functional cueing and that gains in neuroscience knowledge would relate to positive neuropsychological outcomes. Methods: Participants (n=89) were randomized to receive either functional cueing (control group) or compassion cueing (experimental group) and engaged with five 10-minute meditation sessions a week for 4 weeks. All intervention sessions were administered through digital presentation. All participants completed ecological momentary assessments before and after the daily intervention, as well as pre- and postintervention questionnaires. Results: Participants demonstrated significant benefits over time, including increased mindfulness and self-compassion, decreased depression, and gains in neuroscience content (all P<.001); however, no significant between-group differences were found. Daily scores from each day of the intervention showed a statistically significant shift from active toward settled. Importantly, long-term increases in mindfulness were positively correlated to changes in compassion (r=0.326; P=.009) and self-compassion (r=0.424; P<.001) and negatively correlated to changes in anxiety (r=–0.266; P=.03) and depression (r=–0.271; P=.03). Finally, the acute effects of meditation were significantly correlated to the longitudinal outcomes (with a small-to-medium effect size), especially those relevant to mindfulness. Conclusions: We developed a novel neuroscience-based education–meditation program that enhanced self-regulation as evidenced by improved mindfulness, self-compassion, and mood state. Our findings demonstrate the behavioral importance of engaging with mindfulness meditation and reinforce the idea that the benefits of meditation are independent of teacher cueing behavior. Future studies will need to investigate the brain-based changes underlying these meditation-induced outcomes.
Dissociation and other trauma symptomatology are linked to imbalance in the competing neurobehavioral decision systems
Basso, Julia C.; Satyal, Medha K.; McKee, Kevin L.; Lynn, Sarah; Gyamfi, Daphne; Bickel, Warren K. (Frontiers Media, 2024-01-31)
Objective: Dissociation is a conscious state characterized by alterations in sensation and perception and is thought to arise from traumatic life experiences. Previous research has demonstrated that individuals with high levels of dissociation show impairments in cognitive-emotional processes. Therefore, using the Competing Neurobehavioral Decisions System (CNDS) theory, we used statistical modeling to examine whether dissociative experience and trauma symptoms are independently predicted by impulsivity, risk-seeking, affective state (i.e., anxiety, depression, stress, and negative affect), and trauma history. Method: In this cross-sectional study design, data were collected via Amazon Mechanical Turk from a total of n = 557 English-speaking participants in the United States. Using Qualtrics, participants answered a series of self-reported questionnaires and completed several neurocognitive tasks. Three independent multiple linear regression models were conducted to assess whether impulsivity, risk seeking, affective state, and trauma history predict depersonalization, trauma symptoms, and PTSD symptoms. Results: As hypothesized, we found that depersonalization and other trauma symptoms are associated with heightened impulsivity, increased risk-seeking, impaired affective states, and a history of traumatic experiences. Conclusion: We demonstrate that an imbalanced CNDS (i.e., hyperimpulsive/ hypoexecutive), as evidenced by decreased future valuation, increased risk seeking, and impaired affective states, predicts heightened depersonalization and other trauma and PTSD symptomatology. This is the first time that dissociation has been connected to delay discounting (i.e., the tendency to place more value on rewards received immediately compared to farther in the future). Interventions that positively impact areas of the CNDS, such as episodic future thinking or mindfulness meditation, may be a target to help decrease dissociative symptoms.
Genomic Resources of Four Colletotrichum Species (C. fioriniae, C. chrysophilum, C. noveboracense, and C. nupharicola) Threatening Commercial Apple Production in the Eastern United States
Khodadadi, Fatemeh; Giroux, Emily; Bilodeau, Guillaume J.; Jurick, Wayne M. II; Aćimović, Srđan G. (American Phytopathological Society, 2023-03-07)
The genus Colletotrichum includes nine major clades with 252 species and 15 major phylogenetic lineages, also known as species complexes. Colletotrichum spp. are one of the top fungal plant pathogens causing anthracnose and pre- and postharvest fruit rots worldwide. Apple orchards are imperiled by devastating losses from apple bitter rot, ranging from 24 to 98%, which is a serious disease caused by several Colletotrichum species. Bitter rot is also a major postharvest rot disease, with C. fioriniae causing from 2 to 14% of unmarketable fruit in commercial apple storages. Dominant species causing apple bitter rot in the Mid- Atlantic United States are C. fioriniae from the Colletotrichum acutatum species complex and C. chrysophilum and C. noveboracense from the C. gloeosporioides species complex (CGSC). C. fioriniae is the dominant species causing apple bitter rot in the Northeastern and Mid-Atlantic states. C. chrysophilum was first identified on banana and cashew but has been recently found as the second most dominant species causing apple bitter rot in the Mid-Atlantic. As the third most dominant pathogen, C. noveboracense MB 836581 was identified as a novel species in the CGSC, causing apple bitter rot in the Mid-Atlantic. C. nupharicola is a sister group to C. fructicola and C. noveboracense, also causing bitter rot on apple. We deliver the resources of 10 new genomes, including two isolates of C. fioriniae, three isolates of C. chrysophilum, three isolates of C. noveboracense, and two isolates of C. nupharicola collected from apple fruit, yellow waterlily, and Juglans nigra.
Fast and adaptive dynamics-on-graphs to dynamics-of-graphs translation
Zhang, Lei; Chen, Zhiqian; Lu, Chang-Tien; Zhao, Liang (Frontiers, 2023-11-17)
Numerous networks in the real world change with time, producing dynamic graphs such as human mobility networks and brain networks. Typically, the “dynamics on graphs” (e.g., changing node attribute values) are visible, and they may be connected to and suggestive of the “dynamics of graphs” (e.g., evolution of the graph topology). Due to two fundamental obstacles, modeling and mapping between them have not been thoroughly explored: (1) the difficulty of developing a highly adaptable model without solid hypotheses and (2) the ineffectiveness and slowness of processing data with varying granularity. To solve these issues, we offer a novel scalable deep echo-state graph dynamics encoder for networks with significant temporal duration and dimensions. A novel neural architecture search (NAS) technique is then proposed and tailored for the deep echo-state encoder to ensure strong learnability. Extensive experiments on synthetic and actual application data illustrate the proposed method's exceptional effectiveness and efficiency.
Examining the role of urgency in predicting binge size in bulimia nervosa
Davis, Heather A.; Smith, Gregory T. (Frontiers, 2023-05-31)
Greater binge size within bulimia nervosa is associated with elevated distress and impairment. Theoretical models posit that emotion dysregulation predicts binge eating, but little research has investigated the potential for dispositional traits that reflect difficulty in emotion regulation to predict binge size among women with bulimia nervosa. Research supports that negative urgency, the tendency to act rashly when feeling distressed, is associated with binge eating behavior among individuals with bulimia nervosa. Relatively fewer studies have explored associations between binge eating and positive urgency, the tendency to act rashly when feeling extreme positive affect. The urgency traits may predict greater binge size within bulimia nervosa. The current study sought to examine negative urgency and positive urgency as predictors of test meal intake in a sample of 50 women, n = 21 with bulimia nervosa and n = 29 healthy controls. Dispositional levels of positive urgency, negative urgency, positive affect, and negative affect were measured prior to a laboratory binge eating paradigm. Participants in the bulimia nervosa group scored higher on negative urgency, positive urgency, and negative affect than participants in the control group. Across participants, lower levels of negative affect were associated with greater test meal intake. Elevated levels of positive urgency predicted significantly greater test meal intake, but only for participants with bulimia nervosa. No other dispositional traits predicted test meal intake when the interaction of positive urgency and group was included in the model. Findings suggest positive urgency is an underappreciated, but potentially important, risk factor for greater binge size in bulimia nervosa.
Pregnancy-induced remodeling of the murine reproductive tract: a longitudinal in vivo magnetic resonance imaging study
Suarez, Aileen C.; Gimenez, Clara J.; Russell, Serena R.; Wang, Maosen; Munson, Jennifer M.; Myers, Kristin M.; Miller, Kristin S.; Abramowitch, Steven D.; De Vita, Rafaella (Springer, 2024-01-05)
Mammalian pregnancy requires gradual yet extreme remodeling of the reproductive organs to support the growth of the embryos and their birth. After delivery, the reproductive organs return to their non-pregnant state. As pregnancy has traditionally been understudied, there are many unknowns pertaining to the mechanisms behind this remarkable remodeling and repair process which, when not successful, can lead to pregnancy-related complications such as maternal trauma, pre-term birth, and pelvic floor disorders. This study presents the first longitudinal imaging data that focuses on revealing anatomical alterations of the vagina, cervix, and uterine horns during pregnancy and postpartum using the mouse model. By utilizing advanced magnetic resonance imaging (MRI) technology, T1-weighted and T2-weighted images of the reproductive organs of three mice in their in vivo environment were collected at five time points: non-pregnant, mid-pregnant (gestation day: 9–10), late pregnant (gestation day: 16–17), postpartum (24–72 h after delivery) and three weeks postpartum. Measurements of the vagina, cervix, and uterine horns were taken by analyzing MRI segmentations of these organs. The cross-sectional diameter, length, and volume of the vagina increased in late pregnancy and then returned to non-pregnant values three weeks after delivery. The cross-sectional diameter of the cervix decreased at mid-pregnancy before increasing in late pregnancy. The volume of the cervix peaked at late pregnancy before shortening by 24–72 h postpartum. As expected, the uterus increased in cross-sectional diameter, length, and volume during pregnancy. The uterine horns decreased in size postpartum, ultimately returning to their average non-pregnant size three weeks postpartum. The newly developed methods for acquiring longitudinal in vivo MRI scans of the murine reproductive system can be extended to future studies that evaluate functional and morphological alterations of this system due to pathologies, interventions, and treatments.

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