Institute Publications, Fralin Life Sciences Institute

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Newsletters, periodicals, annual reports, and other Institute publications

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Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells
Vora, Shivam; Chatterjee, Saptarshi; Andrew, Ariel; Kumar, Ramyashree Prasanna; Proctor, Martina; Zeng, Zhen; Bhatt, Rituparna; Nazareth, Deborah; Fernando, Madushan; Jones, Mathew J. K.; He, Yaowu; Hooper, John D.; McMillan, Nigel A. J.; Urosevic, Jelena; Saeh, Jamal; Travers, Jon; Cimini, Daniela; Chen, Jing; Gabrielli, Brian (Springer Nature, 2025-01-08)
Polyploidy is a common outcome of chemotherapies, but there is conflicting evidence as to whether polyploidy is an adverse, benign or even favourable outcome. We show Aurora B kinase inhibitors efficiently promote polyploidy in many cell types, resulting in the cell cycle exit in RB and p53 functional cells, but hyper-polyploidy in cells with loss of RB and p53 function. These hyper-polyploid cells (>8n DNA content) are viable but have lost long-term proliferative potential in vitro and fail to form tumours in vivo. Investigation of mitosis in these cells revealed high numbers of centrosomes that were capable of supporting functional mitotic spindle poles, but these failed to progress to anaphase/telophase structures even when AURKB inhibitor was removed after 2–3 days. However, when AURKB inhibitor was removed after 1 day and cells had failed a single cytokinesis to become tetraploid, they retained colony forming ability and long-term proliferative potential. Mathematical modelling of the potential for polyploid cells to produce viable daughter cells demonstrated that cells with >8n DNA and >4 functional spindle poles approach zero probability of a viable daughter, supporting our experimental observations. These findings demonstrate that tetraploidy is tolerated by tumour cells, but higher ploidy states are incompatible with long-term proliferative potential.
The Fralin Explorer, Summer 2019
Fralin Life Sciences Institute (Virginia Tech, 2019-07)
The Fralin Explorer is intended to keep faculty, research personnel, and students up-to-date about what is going on within the Institute, and to highlight examples of significant achievements by our affiliated faculty members.
9th Hellbender Symposium
(Virginia Tech. Global Change Center, 2019-06)
The Hellbender Symposium is a biennial event where hellbender researchers from all over the United States and other parts of the world meet to present and discuss their research.
BIOTRANS 2018, Vol. 3
BIOTRANS (Virginia Tech, 2018)
BIOTRANS is a community of biologists and engineers that work together to study transport in environmental and physiological systems.
The Fralin Explorer, Fall 2018
Fralin Life Sciences Institute (Virginia Tech, 2018-12)
The Fralin Explorer is intended to keep faculty, research personnel, and students up-to-date about what is going on within the Institute, and to highlight examples of significant achievements by our affiliated faculty members.
Growing MPS, 2014 vol. 1
Molecular Plant Sciences; Fralin Life Sciences Institute (Virginia Tech, 2014)
The VT Molecular Plant Sciences Magazine features the work of scientists and students in the department who use molecular approaches to unravel the mysteries of plants.
Growing TPS, 2016 vol. 2
Translational Plant Sciences; Fralin Life Sciences Institute (Virginia Tech, 2016)
The annual magazine for the Virginia Tech Translational Plant Sciences (TPS) graduate program, formerly Molecular Plant Sciences (MPS).
Growing TPS, 2015 vol. 1
Translational Plant Sciences; Fralin Life Sciences Institute (Virginia Tech, 2015)
The annual magazine for the Virginia Tech Translational Plant Sciences (TPS) graduate program, formerly Molecular Plant Sciences (MPS).
The Fralin Explorer, Spring 2016
Fralin Life Sciences Institute (Virginia Tech, 2016)
The Fralin Explorer is intended to keep faculty, research personnel, and students up-to-date about what is going on within the Institute, and to highlight examples of significant achievements by our affiliated faculty members.
The Fralin Explorer, Spring 2014
Fralin Life Sciences Institute (Virginia Tech, 2014)
The Fralin Explorer is intended to keep faculty, research personnel, and students up-to-date about what is going on within the Institute, and to highlight examples of significant achievements by our affiliated faculty members.
The Fralin Explorer, Fall 2014
Fralin Life Sciences Institute (Virginia Tech, 2014)
The Fralin Explorer is intended to keep faculty, research personnel, and students up-to-date about what is going on within the Institute, and to highlight examples of significant achievements by our affiliated faculty members.
The Fralin Explorer, Fall 2016
Fralin Life Sciences Institute (Virginia Tech, 2016)
The Fralin Explorer is intended to keep faculty, research personnel, and students up-to-date about what is going on within the Institute, and to highlight examples of significant achievements by our affiliated faculty members.
Fralin Undergraduate Research Fellowship Showcase
Fralin Life Sciences Institute (Virginia Tech, 2017-04-20)
This booklet features the 2016-2017 Fralin Undergraduate Fellows, their research abstracts, and a showcase schedule for April 20, 2017.
The Fralin Explorer, Fall 2015
Fralin Life Sciences Institute (Virginia Tech, 2015)
The Fralin Explorer is intended to keep faculty, research personnel, and students up-to-date about what is going on within the Institute, and to highlight examples of significant achievements by our affiliated faculty members.
The Fralin Explorer, Spring 2015
Fralin Life Sciences Institute (Virginia Tech, 2015)
The Fralin Explorer is intended to keep faculty, research personnel, and students up-to-date about what is going on within the Institute, and to highlight examples of significant achievements by our affiliated faculty members.
The Fralin Explorer, Spring 2013
Fralin Life Sciences Institute (Virginia Tech, 2013)
The Fralin Explorer is intended to keep faculty, research personnel, and students up-to-date about what is going on within the Institute, and to highlight examples of significant achievements by our affiliated faculty members.
The Fralin Explorer, Spring 2017
Fralin Life Sciences Institute (Virginia Tech, 2017)
The Fralin Explorer is intended to keep faculty, research personnel, and students up-to-date about what is going on within the Institute, and to highlight examples of significant achievements by our affiliated faculty members.
The Fralin Explorer, Fall/Winter 2013
Fralin Life Sciences Institute (Virginia Tech, 2013)
The Fralin Explorer is intended to keep faculty, research personnel, and students up-to-date about what is going on within the Institute, and to highlight examples of significant achievements by our affiliated faculty members.
The Fralin Explorer, Spring 2018
Fralin Life Sciences Institute (Virginia Tech, 2018)
The Fralin Explorer is intended to keep faculty, research personnel, and students up-to-date about what is going on within the Institute, and to highlight examples of significant achievements by our affiliated faculty members.
BIOTRANS 2016
BIOTRANS (Virginia Tech, 2016)
BIOTRANS is a community of biologists and engineers that work together to study transport in environmental and physiological systems.