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dc.contributor.authorMu, Qinghuien
dc.contributor.authorSwartwout, Brianna K.en
dc.contributor.authorEdwards, Michaelen
dc.contributor.authorZhu, Jingen
dc.contributor.authorLee, Graceen
dc.contributor.authorEden, Kristinen
dc.contributor.authorCabana-Puig, Xavieren
dc.contributor.authorMcDaniel, Dylan K.en
dc.contributor.authorMao, Jiangdien
dc.contributor.authorAbdelhamid, Leilaen
dc.contributor.authorBrock, Rebecca M.en
dc.contributor.authorAllen, Irving Coyen
dc.contributor.authorReilly, Christopher M.en
dc.contributor.authorLuo, Xin M.en
dc.description.abstractInfants are prone to enteric infections due to an underdeveloped immune system. The maternal microbiota, through shaping the neonatal microbiota, helps establish a strong immune system in infants. We and others have observed the phenomenon of enhanced early neonatal immunoglobulin A (IgA) production in preweaning immunocompetent mice nursed by immunodeficient dams. Here, we show that this enhancement of IgA in neonates results from maternally derived microbiota. In addition, we have found that the neonatal IgA production can be induced by Lactobacillus reuteri, which is enriched in the milk of immunodeficient dams. Moreover, we show that while the production of neonatal IgA is dependent on neonatal T cells, the immunodeficient maternal microbiota-mediated enhancement of neonatal IgA has a T cell– independent component. Indeed, this enhancement may be dependent on type 3 innate lymphoid cells in the neonatal small intestinal lamina propria. Interestingly, maternal microbiotainduced neonatal IgA does not cross-react with common enteric pathogens. Future investigations will determine the functional consequences of having this extra IgA.en
dc.publisherNational Academy of Sciencesen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.subjectmaternal microbiotaen
dc.subjectneonatal IgAen
dc.subjectLactobacillus reuterien
dc.subjectT cellsen
dc.subjecttype 3 innate lymphoid cellsen
dc.titleRegulation of neonatal IgA production by the maternal microbiotaen
dc.typeArticle - Refereeden

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