Show simple item record

dc.contributor.authorMu, Qinghuien
dc.contributor.authorSwartwout, Brianna K.en
dc.contributor.authorEdwards, Michaelen
dc.contributor.authorZhu, Jingen
dc.contributor.authorLee, Graceen
dc.contributor.authorEden, Kristinen
dc.contributor.authorCabana-Puig, Xavieren
dc.contributor.authorMcDaniel, Dylan K.en
dc.contributor.authorMao, Jiangdien
dc.contributor.authorAbdelhamid, Leilaen
dc.contributor.authorBrock, Rebecca M.en
dc.contributor.authorAllen, Irving Coyen
dc.contributor.authorReilly, Christopher M.en
dc.contributor.authorLuo, Xin M.en
dc.date.accessioned2021-03-04T15:33:13Zen
dc.date.available2021-03-04T15:33:13Zen
dc.date.issued2021-02-22en
dc.identifier.urihttp://hdl.handle.net/10919/102608en
dc.description.abstractInfants are prone to enteric infections due to an underdeveloped immune system. The maternal microbiota, through shaping the neonatal microbiota, helps establish a strong immune system in infants. We and others have observed the phenomenon of enhanced early neonatal immunoglobulin A (IgA) production in preweaning immunocompetent mice nursed by immunodeficient dams. Here, we show that this enhancement of IgA in neonates results from maternally derived microbiota. In addition, we have found that the neonatal IgA production can be induced by Lactobacillus reuteri, which is enriched in the milk of immunodeficient dams. Moreover, we show that while the production of neonatal IgA is dependent on neonatal T cells, the immunodeficient maternal microbiota-mediated enhancement of neonatal IgA has a T cell– independent component. Indeed, this enhancement may be dependent on type 3 innate lymphoid cells in the neonatal small intestinal lamina propria. Interestingly, maternal microbiotainduced neonatal IgA does not cross-react with common enteric pathogens. Future investigations will determine the functional consequences of having this extra IgA.en
dc.language.isoen_USen
dc.publisherNational Academy of Sciencesen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectmaternal microbiotaen
dc.subjectneonatal IgAen
dc.subjectLactobacillus reuterien
dc.subjectT cellsen
dc.subjecttype 3 innate lymphoid cellsen
dc.titleRegulation of neonatal IgA production by the maternal microbiotaen
dc.typeArticle - Refereeden
dc.title.serialPNASen
dc.identifier.doihttps://doi.org/10.1073/pnas.2015691118en
dc.identifier.volume118en
dc.identifier.issue9en


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 International
License: Attribution-NonCommercial-NoDerivatives 4.0 International