Scholars widely accept that the well-documented benefits of biophilia–the human being's strong urge to connect with nature–are genuine to improved health. Then why, with the global acceptance and scientific validity of wellness design concepts, do architects not use this beneficial concept regularly–especially when designing isolated workspaces? This qualitative research explores architecture's current design decision process to better understand this design phenomenon, and to identify where architectural biophilic knowledge domains may be deficient. This study explores questions such as: Does the architect's lack of biophilic knowledge and/or structured wellness design decision support framework affect the decision? Would the existence of a wellness design tool better support the design decision? An explanatory case study using a purposeful study sample of architects, biophilia design experts, and associated specialists is used to develop design decision support frameworks. Level 1 establishes a propositional theory derived from the literature and professional experience, level 2 from architect interviews and observational meetings, and level 3 from a Delphi workgroup session. Framework evolutions help identify design-phase-specific knowledge gaps. This study finds that a deficiency in early exposure to a priori, explicit and tacit biophilic knowledge is creating a critical gap, thus diminishing a posteriori biophilic knowledge and research in the architecture profession. This study asserts that early exposure to biophilic theories and principles can enhance the profession and provide a knowledge bridge using an informed biophilia design support framework with a proposed biophilia project management tool.