Note: In 2019, the Biocomplexity Institute became part of the Fralin Life Sciences Institute.

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  • Nutritional protective mechanisms against gut inflammation 

    Viladomiu, Monica; Hontecillas, Raquel; Yuan, Lijuan; Lu, Pinyi; Bassaganya-Riera, Josep (Elsevier, 2013-01-15)
    Inflammatory bowel disease (IBD) is a debilitating and widespread immune-mediated illness characterized by excessive inflammatory and effector mucosal responses leading to tissue destruction at the gastrointestinal tract. ...
  • A survey of quality of life indicators in the Romanian Roma population following the ‘Decade of Roma Inclusion’ 

    Doherty, Rebecca Powell; Telionis, Pyrros A.; Müller-Demary, Daniel; Hosszu, Alexandra; Duminica, Ana; Bertke, Andrea; Lewis, Bryan; Eubank, Stephen (F1000Research, 2019-09-18)
    Background: This study explores how the Roma in Romania, the EU’s most concentrated population, are faring in terms of a number of quality of life indicators, including poverty levels, healthcare, education, water, sanitation, ...
  • The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats 

    Allen, Mitchell E.; Pennington, Edward Ross; Perry, Justin B.; Dadoo, Sahil; Makrecka-Kuka, Marina; Dambrova, Maija; Moukdar, Fatiha; Patel, Hetal D.; Han, Xianlin; Kidd, Grahame K.; Benson, Emily K.; Raisch, Tristan B.; Poelzing, Steven; Brown, David A.; Shaikh, Saame Raza (2020-07-17)
    Allen and Pennington et al. show that the cardiolipin-binding peptide elamipretide mitigates disease-induced fragmentation of cristae networks following cardiac ischemia reperfusion in rats. This study suggests that ...
  • Using artificial intelligence for improving stroke diagnosis in emergency departments: a practical framework 

    Abedi, Vida; Khan, Ayesha; Chaudhary, Durgesh; Misra, Debdipto; Avula, Venkatesh; Mathrawala, Dhruv; Kraus, Chadd; Marshall, Kyle A.; Chaudhary, Nayan; Li, Xiao; Schirmer, Clemens M.; Scalzo, Fabien; Li, Jiang; Zand, Ramin (2020-08)
    Stroke is the fifth leading cause of death in the United States and a major cause of severe disability worldwide. Yet, recognizing the signs of stroke in an acute setting is still challenging and leads to loss of opportunity ...
  • Structural, in silico, and functional analysis of a Disabled-2-derived peptide for recognition of sulfatides 

    Song, Wei; Gottschalk, Carter J.; Tang, Tuo-Xian; Biscardi, Andrew; Ellena, Jeffrey F.; Finkielstein, Carla, V; Brown, Anne M.; Capelluto, Daniel G. S. (2020-08-11)
    Disabled-2 (Dab2) is an adaptor protein that regulates the extent of platelet aggregation by two mechanisms. In the first mechanism, Dab2 intracellularly downregulates the integrin alpha (IIb)beta (3) receptor, converting ...
  • Inactivation of Aeromonas hydrophila and Vibrio parahaemolyticus by Curcumin-Mediated Photosensitization and Nanobubble-Ultrasonication Approaches 

    Rafeeq, Shamil; Shiroodi, Setareh; Schwarz, Michael H.; Nitin, Nitin; Ovissipour, Mahmoudreza (MDPI, 2020-09-16)
    The antimicrobial efficacy of novel photodynamic inactivation and nanobubble technologies was evaluated against Vibrio parahaemolyticus and Aeromonas hydrophila as two important aquatic microbial pathogens. ...
  • Critical role of deadenylation in regulating poly(A) rhythms and circadian gene expression 

    Yao, Xiangyu; Kojima, Shihoko; Chen, Jing (2020-04)
    The mammalian circadian clock is deeply rooted in rhythmic regulation of gene expression. Rhythmic transcriptional control mediated by the circadian transcription factors is thought to be the main driver of mammalian ...
  • Associations between peer attachment and neural correlates of risk processing across adolescence 

    Asscheman, J. Susanne; Deater-Deckard, Kirby; Lauharatanahirun, Nina; van Lier, Pol A. C.; Koot, Susanne; King-Casas, Brooks; Kim-Spoon, Jungmeen (2020-04)
    Adolescence is a period of increased risk-taking behavior where individual differences in risk taking may relate to both adverse and positive experiences with peers. Yet, knowledge on how risk processing develops in the ...
  • Photoacoustic microscopy reveals the hemodynamic basis of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke 

    Cao, Rui; Li, Jun; Kharel, Yugesh; Zhang, Chenchu; Morris, Emily; Santos, Webster L.; Lynch, Kevin R.; Zuo, Zhiyi; Hu, Song (IvySpring, 2018-11-29)
    Rationale: Emerging evidence has suggested that sphingosine 1-phosphate (S1P), a bioactive metabolite of sphingolipids, may play an important role in the pathophysiological processes of cerebral hypoxia and ischemia. ...
  • Mechanism of sphingosine 1-phosphate clearance from blood 

    Kharel, Yugesh; Huang, Tao; Salamon, Anita; Harris, Thurl E.; Santos, Webster L.; Lynch, Kevin R. (Portland Press, 2020-03-06)
    The interplay of sphingosine 1-phosphate (S1P) synthetic and degradative enzymes as well as S1P exporters creates concentration gradients that are a fundamental to S1P biology. Extracellular S1P levels, such as in blood ...
  • Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane 

    Kenwood, Brandon M.; Weaver, Janelle L.; Bajwa, Amandeep; Poon, Ivan K.; Byrne, Frances L.; Murrow, Beverley A.; Calderone, Joseph A.; Huang, Liping; Divakaruni, Ajit S.; Tomsig, Jose L.; Okabe, Kohki; Lo, Ryan H.; Coleman, G. Cameron; Columbus, Linda; Yan, Zhen; Saucerman, Jeffrey J.; Smith, Jeffrey S.; Holmes, Jeffrey W.; Lynch, Kevin R.; Ravichandran, Kodi S.; Uchiyama, Seiichi; Santos, Webster L.; Rogers, George W.; Okusa, Mark D.; Bayliss, Douglas A.; Hoehn, Kyle L. (Elsevier, 2013)
    Dysregulation of oxidative phosphorylation is associated with increased mitochondrial reactive oxygen species production and some of the most prevalent human diseases including obesity, cancer, diabetes, neurodegeneration, ...
  • Improved reference genome of the arboviral vector Aedes albopictus 

    Palatini, Umberto; Masri, Reem A.; Cosme, Luciano V.; Koren, Sergey; Thibaud-Nissen, Françoise; Biedler, James K.; Krsticevic, Flavia; Johnston, J. S.; Halbach, Rebecca; Crawford, Jacob E.; Antoshechkin, Igor; Failloux, Anna-Bella; Pischedda, Elisa; Marconcini, Michele; Ghurye, Jay; Rhie, Arang; Sharma, Atashi; Karagodin, Dmitry A.; Jenrette, Jeremy; Gamez, Stephanie; Miesen, Pascal; Masterson, Patrick; Caccone, Adalgisa; Sharakhova, Maria V.; Tu, Zhijian; Papathanos, Philippos A.; Van Rij, Ronald P.; Akbari, Omar S.; Powell, Jeffrey R.; Phillippy, Adam M.; Bonizzoni, Mariangela (2020-08-26)
    Abstract Background The Asian tiger mosquito Aedes albopictus is globally expanding and has become the main vector for human arboviruses in Europe. With limited antiviral ...
  • Genomic differentiation and intercontinental population structure of mosquito vectors Culex pipiens pipiens and Culex pipiens molestus 

    Yurchenko, Andrey A.; Masri, Reem A.; Khrabrova, Natalia, V.; Sibataev, Anuarbek K.; Fritz, Megan L.; Sharakhova, Maria, V. (2020-05-05)
    Understanding the population structure and mechanisms of taxa diversification is important for organisms responsible for the transmission of human diseases. Two vectors of West Nile virus, Culex pipiens pipiens and Cx. p. ...
  • Global Distribution and Evolution of Mycobacterium bovis Lineages 

    Zimpel, Cristina Kraemer; Patane, Jose Salvatore L.; Proenga Guedes, Aureliano Coelho; de Souza, Robson F.; Silva-Pereira, Taiana T.; Soler Camargo, Naila C.; de Souza Filho, Antonio F.; Ikuta, Cassia Y.; Ferreira Neto, Jose Soares; Setubal, Joao Carlos; Heinemann, Marcos Bryan; Sa Guimaraes, Ana Marcia (2020-05-07)
    Mycobacterium bovis is the main causative agent of zoonotic tuberculosis in humans and frequently devastates livestock and wildlife worldwide. Previous studies suggested the existence of genetic groups of M. bovis strains ...
  • Dietary and Biological Assessment of the Omega-3 Status of Collegiate Athletes: A Cross-Sectional Analysis 

    Ritz, Peter P.; Rogers, Mark B.; Zabinsky, Jennifer S.; Hedric, Valisa E.; Rockwell, John A.; Rimef, Ernest G.; Kostelnik, Samantha B.; Hulver, Matthew W.; Rockwell, Michelle S. (PLOS, 2020-04-29)
    Omega-3 fatty acids (ω-3 FA) are associated with cardiovascular health, brain function, reduction of inflammation, and several other physiological roles of importance to competitive athletes. The ω-3 FA status of National ...
  • Characterization of a female germline and early zygote promoter from the transcription factor bZip1 in the dengue mosquito Aedes aegypti 

    Kojin, Bianca B.; Biedler, James K.; Tu, Zhijian; Adelman, Zach N. (2020-07-17)
    Abstract Background The wide distribution of Aedes aegypti, the main vector of dengue and yellow fever viruses, currently puts three billion people in the world at risk of infection with these viruses. Continuous transmission ...
  • Nix alone is sufficient to convert female Aedes aegypti into fertile males and myo-sex is needed for male flight 

    Aryan, Azadeh; Anderson, Michelle A.E.; Biedler, James K.; Qi, Yumin; Overcash, Justin M.; Naumenko, Anastasia N.; Sharakova, Maria V.; Mao, Chunhong; Adelman, Zach N.; Tu, Zhijian (NAS, 2020-06-12)
    A dominant male-determining locus (M-locus) establishes the male sex (M/m) in the yellow fever mosquito, Aedes aegypti. Nix, a gene in the M-locus, was shown to be a male-determining factor (M factor) as somatic knockout ...
  • EGR2 is elevated and positively regulates inflammatory IFNγ production in lupus CD4+ T cells 

    Dai, Rujuan; Heid, Bettina; Xu, Xiguang; Xie, Hehuang; Reilly, Christopher M.; Ahmed, S. A. (2020-07-09)
    Abstract Background Recent studies have shown that early growth response 2 (EGR2) is highly induced in activated T cells and regulates T cell functions. In normal C57BL/6 ...
  • A predictive analytics model for differentiating between transient ischemic attacks (TIA) and its mimics 

    Stanciu, Alia; Banciu, Mihai; Sadighi, Alireza; Marshall, Kyle A.; Holland, Neil R.; Abedi, Vida; Zand, Ramin (2020-06-18)
    Abstract Background Transient ischemic attack (TIA) is a brief episode of neurological dysfunction resulting from cerebral ischemia not associated with permanent cerebral infarction. TIA is associated with high diagnostic ...
  • Gut Microbiota Profile of Obese Diabetic Women Submitted to Roux-en-Y Gastric Bypass and Its Association with Food Intake and Postoperative Diabetes Remission 

    Al Assal, Karina; Prifti, Edi; Belda, Eugeni; Sala, Priscila; Clement, Karine; Dao, Maria-Carlota; Dore, Joel; Levenez, Florence; Taddei, Carla R.; Fonseca, Danielle Cristina; Rocha, Ilanna Marques; Balmant, Bianca Depieri; Thomas, Andrew M.; Santo, Marco A.; Dias-Neto, Emmanuel; Setubal, Joao Carlos; Zucker, Jean-Daniel; Belarmino, Giliane; Torrinhas, Raquel Susana; Waitzberg, Dan L. (2020-02)
    Gut microbiota composition is influenced by environmental factors and has been shown to impact body metabolism. Objective: To assess the gut microbiota profile before and after Roux-en-Y gastric bypass (RYGB) and the ...

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