Note: In 2019, the Biocomplexity Institute became part of the Fralin Life Science Institute.

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  • Origin and diversification of Xanthomonas citri subsp. citri pathotypes revealed by inclusive phylogenomic, dating, and biogeographic analyses 

    Patané, José S. L.; Martins, Joaquim; Rangel, Luiz T.; Belasque, José; Digiampietri, Luciano A.; Facincani, Agda P.; Ferreira, Rafael M.; Jaciani, Fabrício J.; Zhang, Yunzeng; Varani, Alessandro M.; Almeida, Nalvo F.; Wang, Nian; Ferro, Jesus A.; Moreira, Leandro M.; Setubal, João C. (2019-09-09)
    Abstract Background Xanthomonas citri subsp. citri pathotypes cause bacterial citrus canker, being responsible for severe agricultural losses worldwide. The A pathotype has a ...
  • Improved reference genome of Aedes aegypti informs arbovirus vector control 

    Matthews, Benjamin J.; Dudchenko, Olga; Kingan, Sarah B.; Koren, Sergey; Antoshechkin, Igor; Crawford, Jacob E.; Glassford, William J.; Herre, Margaret; Redmond, Seth N.; Rose, Noah H.; Weedall, Gareth D.; Wu, Yang; Batra, Sanjit S.; Brito-Sierra, Carlos A.; Buckingham, Steven D.; Campbell, Corey L.; Chan, Saki; Cox, Eric; Evans, Benjamin R.; Fansiri, Thanyalak; Filipovic, Igor; Fontaine, Albin; Gloria-Soria, Andrea; Hall, Richard; Joardar, Vinita S.; Jones, Andrew K.; Kay, Raissa G. G.; Kodali, Vamsi K.; Lee, Joyce; Lycett, Gareth J.; Mitchell, Sara N.; Muehling, Jill; Murphy, Michael R.; Omer, Arina D.; Partridge, Frederick A.; Peluso, Paul; Aiden, Aviva Presser; Ramasamy, Vidya; Rasic, Gordana; Roy, Sourav; Saavedra-Rodriguez, Karla; Sharan, Shruti; Sharma, Atashi; Smith, Melissa Laird; Turner, Joe; Weakley, Allison M.; Zhao, Zhilei; Akbari, Omar S.; Black, William C.; Cao, Han; Darby, Alistair C.; Hill, Catherine A.; Johnston, J. Spencer; Murphy, Terence D.; Raikhel, Alexander S.; Sattelle, David B.; Sharakhov, Igor V.; White, Bradley J.; Zhao, Li; Aiden, Erez Lieberman; Mann, Richard S.; Lambrechts, Louis; Powell, Jeffrey R.; Sharakhova, Maria V.; Tu, Zhijian; Robertson, Hugh M.; McBride, Carolyn S.; Hastic, Alex R.; Korlach, Jonas; Neafsey, Daniel E.; Phillippy, Adam M.; Vosshall, Leslie B. (2018-11-22)
    Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and ...
  • Risk Assessment in Chinese Hospitalized Patients Comparing the Padua and Caprini Scoring Algorithms 

    Chen, Xiaolan; Pan, Lei; Deng, Hui; Zhang, Jingyuan; Tong, Xinjie; Huang, He; Zhang, Min; He, Jianlin; Caprini, Joseph A.; Wang, Yong (2018-12)
    The current venous thromboembolism (VTE) guidelines recommend all patients to be assessed for the risk of VTE using risk assessment models (RAMs). The study was to evaluate the performance of the Caprini and Padua RAMs ...
  • 9th Hellbender Symposium 

    Unknown author (Virginia Tech. Global Change Center, 2019-06)
    The Hellbender Symposium is a biennial event where ​hellbender researchers from all over the United States and other parts of the world meet to present and discuss their research.
  • Environmental stresses induce karyotypic instability in colorectal cancer cells 

    Tan, Zhihao; Chan, Yong Jie Andrew; Chua, Ying Jie Karen; Rutledge, Samuel D.; Pavelka, Norman; Cimini, Daniela; Rancati, Giulia (2019-01)
    Understanding how cells acquire genetic mutations is a fundamental biological question with implications for many different areas of biomedical research, ranging from tumor evolution to drug resistance. While karyotypic ...
  • Innate Immunity Induced by the Major Allergen Alt a 1 From the Fungus Alternaria Is Dependent Upon Toll-Like Receptors 2/4 in Human Lung Epithelial Cells 

    Hayes, Tristan; Rumore, Amanda; Howard, Brad; He, Xin; Luo, Mengyao; Wuenschmann, Sabina; Chapman, Martin; Kale, Shiv; Li, Liwu; Kita, Hirohito; Lawrence, Christopher B. (2018-07-30)
    Allergens are molecules that elicit a hypersensitive inflammatory response in sensitized individuals and are derived from a variety of sources. Alt a 1 is the most clinically important secreted allergen of the ubiquitous ...
  • Divergent age-dependent peripheral immune transcriptomic profile following traumatic brain injury 

    Hazy, Amanda; Bochicchio, Lauren; Oliver, Andrea; Xie, Eric; Geng, Shuo; Brickler, Thomas; Xie, Hehuang; Li, Liwu; Allen, Irving C.; Theus, Michelle H. (2019-06-12)
    The peripheral immune system is a major regulator of the pathophysiology associated with traumatic brain injury (TBI). While age-at-injury influences recovery from TBI, the differential effects on the peripheral immune ...
  • Fatgraph models of RNA structure 

    Huang, Fenix; Reidys, Christian; Rezazadegan, Reza (De Gruyter, 2017-02-08)
    In this review paper we discuss fatgraphs as a conceptual framework for RNA structures. We discuss various notions of coarse-grained RNA structures and relate them to fatgraphs. We motivate and discuss the main intuition ...
  • Diminished single-stimulus response in vmPFC to favorite people in children diagnosed with Autism Spectrum Disorder 

    Kishida, Kenneth T.; De Asis-Cruz, Josepheen; Treadwell-Deering, Diane; Liebenow, Brittany; Beauchamp, Michael S.; Montague, P. Read (2019-07)
    From an early age, individuals with autism spectrum disorder (ASD) spend less time engaged in social interaction compared to typically developing peers (TD). One reason behind this behavior may be that the brains of children ...
  • Genomic divergence and adaptive convergence in Drosophila simulans from Evolution Canyon, Israel 

    Kang, Lin; Rashkovetsky, Eugenia; Michalak, Katarzyna; Garner, Harold R.; Mahaney, James E.; Rzigalinski, Beverly A.; Korol, Abraham; Nevo, Eviatar; Michalak, Pawel (2019-06-11)
    Biodiversity refugia formed by unique features of the Mediterranean arid landscape, such as the dramatic ecological contrast of "Evolution Canyon," provide a natural laboratory in which local adaptations to divergent ...
  • Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism 

    Fachi, Jose Luis; Felipe, Jaqueline de Souza; Pral, Lais Passariello; da Silva, Bruna Karadi; Correa, Renan Oliveira; Pereira de Andrade, Mirella Cristiny; da Fonseca, Denise Morais; Basso, Paulo Jose; Saraiva Camara, Niels Olsen; de Sales e Souza, Ericka Lorenna; Martins, Flaviano dos Santos; Sato Guima, Suzana Eiko; Thomas, Andrew Maltez; Setubal, Joao Carlos; Magalhaes, Yuli Thamires; Forti, Fabio Luis; Candreva, Thamiris; Rodrigues, Hosana Gomes; de Jesus, Marcelo Bispo; Consonni, Silvio Roberto; Farias, Alessandro dos Santos; Varga-Weisz, Patrick; Ramirez Vinolo, Marco Aurelio (Cell Press, 2019-04-16)
    Antibiotic-induced dysbiosis is a key factor predisposing intestinal infection by Clostridium difficile. Here, we show that interventions that restore butyrate intestinal levels mitigate clinical and pathological features ...
  • Insights into the Evolution of Longevity from the Bowhead Whale Genome 

    Keane, Michael; Semeiks, Jeremy; Webb, Andrew E.; Li, Yang I.; Quesada, Victor; Craig, Thomas; Madsen, Lone Bruhn; van Dam, Sipko; Brawand, David; Marques, Patricia I.; Michalak, Pawel; Kang, Lin; Bhak, Jong; Yim, Hyung-Soon; Grishin, Nick V.; Nielsen, Nynne Hjort; Heide-Jorgensen, Mads Peter; Oziolor, Elias M.; Matson, Cole W.; Church, George M.; Stuart, Gary W.; Patton, John C.; George, J. Craig; Suydam, Robert; Larsen, Knud; Lopez-Otin, Carlos; O'Connell, Mary J.; Bickham, John W.; Thomsen, Bo; de Magalhaes, Joao Pedro (Cell Press, 2015-01-06)
    The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly ...
  • Same influenza vaccination strategies but different outcomes across US cities? 

    Taylor, Claudia; Marathe, Achla; Beckman, Richard (International Society for Infectious Diseases, 2010-09)
    Objectives: This research aimed to determine if the same influenza vaccination strategies would have the same level of effectiveness when applied to two different US metropolitan areas, Miami and Seattle, where the composition ...
  • Comparative nutritional and chemical phenome of Clostridium difficile isolates determined using phenotype microarrays 

    Scaria, Joy; Chen, Jenn-Wei; Useh, Nicodemus; He, Hongxuan; McDonough, Sean P.; Mao, Chunhong; Sobral, Bruno; Chang, Yung-Fu (International Society for Infectious Diseases, 2014-10)
    Objectives: Clostridium difficile infection (CDI) is the leading cause of infectious diarrhea in North America and Europe. The risk of CDI increases significantly in the case where antimicrobial treatment reduces the number ...
  • Dual African Origins of Global Aedes aegypti s.l. Populations Revealed by Mitochondrial DNA 

    Moore, Michelle; Sylla, Massamba; Goss, Laura; Burugu, Marion Warigia; Sang, Rosemary; Kamau, Luna W.; Kenya, Eucharia Unoma; Bosio, Chris; de Lourdes Munoz, Maria; Sharakhova, Maria V.; Black, William Cormack (PLOS, 2013-04)
    Background: Aedes aegypti is the primary global vector to humans of yellow fever and dengue flaviviruses. Over the past 50 years, many population genetic studies have documented large genetic differences among global ...
  • Cooler Temperatures Destabilize RNA Interference and Increase Susceptibility of Disease Vector Mosquitoes to Viral Infection 

    Adelman, Zach N.; Anderson, Michelle A. E.; Wiley, Michael R.; Murreddu, Marta G.; Samuel, Glady Hazitha; Morazzani, Elaine M.; Myles, Kevin M. (PLOS, 2013-05)
    Background: The impact of global climate change on the transmission dynamics of infectious diseases is the subject of extensive debate. The transmission of mosquito-borne viral diseases is particularly complex, with climatic ...
  • Reproductive Incompatibility Involving Senegalese Aedes aegypti (L) Is Associated with Chromosome Rearrangements 

    Dickson, Laura B.; Sharakhova, Maria V.; Timoshevskiy, Vladimir A.; Fleming, Karen L.; Caspary, Alex; Sylla, Massamba; Black, William C. (PLOS, 2016-04)
    Aedes aegypti, the primary vector of dengue, yellow fever and Zika flaviviruses, consists of at least two subspecies. Aedes aegypti (Aaa) is light in color, has pale scales on the first abdominal tergite, oviposits in ...
  • Schistosoma mansoni Egg, Adult Male and Female Comparative Gene Expression Analysis and Identification of Novel Genes by RNA-Seq 

    Anderson, Leticia; Amaral, Murilo S.; Beckedorff, Felipe; Silva, Lucas F.; Dazzani, Bianca; Oliveira, Katia C.; Almeida, Giulliana T.; Gomes, Monete R.; Pires, David S.; Setubal, Joao C.; DeMarco, Ricardo; Verjovski-Almeida, Sergio (PLOS, 2015-12)
    Background Schistosomiasis is one of the most prevalent parasitic diseases worldwide and is a public health problem. Schistosoma mansoni is the most widespread species responsible for schistosomiasis in the Americas, Middle ...
  • Optimization of sand fly embryo microinjection for gene editing by CRISPR/Cas9 

    Martin-Martin, Ines; Aryan, Azadeh; Meneses, Claudio; Adelman, Zach N.; Calvo, Eric (PLOS, 2018-09)
    Background Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology has rapidly emerged as a very effective tool for gene editing. Although great advances on gene editing in the medical entomology ...

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