Fralin Life Sciences Institute
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Note: In 2019, the Biocomplexity Institute became part of the Fralin Life Sciences Institute.
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Global Change Center [82]
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Institute Publications, Fralin Life Sciences Institute [55]
Newsletters, periodicals, annual reports, and other Institute publications -
Scholarly Works, Fralin Life Sciences Institute [541]
Research articles, presentations, and other works by Fralin-affiliated faculty.
Recent Submissions
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Tonian carbonaceous compressions indicate that Horodyskia is one of the oldest multicellular and coenocytic macro-organisms
(Nature Portfolio, 2023-04)Macrofossils with unambiguous biogenic origin and predating the one-billion-year-old multicellular fossils Bangiomorpha and Proterocladus interpreted as crown-group eukaryotes are quite rare. Horodyskia is one of these few ... -
La Crosse Virus Circulation in Virginia, Assessed via Serosurveillance in Wildlife Species
(MDPI, 2023-06-30)Mosquito-borne La Crosse virus (LACV; family: Peribunyaviridae) is the leading cause of pediatric arboviral encephalitis in the United States, with clinical cases generally centered in the Midwest and Appalachian ... -
Enzyme-Triggered Chemodynamic Therapy via a Peptide-H2S Donor Conjugate with Complexed Fe2+
(Wiley-V C H Verlag, 2023-04)Inducing high levels of reactive oxygen species (ROS) inside tumor cells is a cancer therapy method termed chemodynamic therapy (CDT). Relying on delivery of Fenton reaction promoters such as Fe2+, CDT takes advantage of ... -
The minimal intrinsic stochasticity of constitutively expressed eukaryotic genes is sub-Poissonian
(American Association for the Advancement of Science, 2023-08-09)Gene expression inherently gives rise to stochastic variation (“noise”) in the production of gene products. Minimizing noise is crucial for ensuring reliable cellular functions. However, noise cannot be suppressed below a ... -
IGC Graduate Research Symposium, April 21, 2023
(Virginia Tech, 2023-04-21)A detailed agenda and abstracts from the graduate research symposium held in the Moss Arts Center on April 21, 2023. -
IGC Graduate Research Symposium Agenda 2022
(Virginia Tech, 2022-04-22)A detailed agenda and abstracts for the graduate research symposium held in the Graduate Life Center Multipurpose Room on April 22, 2022. -
Sex-Linked Growth Disorder and Aberrant Pituitary Gene Expression in Nestin-Cre-Mediated Egr1 Conditional Knockout Mice
(MDPI, 2023-07-06)Genes that regulate hormone release are essential for maintaining metabolism and energy balance. Egr1 encodes a transcription factor that regulates hormone production and release, and a decreased in growth hormones ... -
Genetic Diversity of Newcastle Disease Virus Involved in the 2021 Outbreaks in Backyard Poultry Farms in Tanzania
(MDPI, 2023-07-21)Newcastle disease virus is a significant avian pathogen with the potential to decimate poultry populations all over the world and cause enormous economic losses. Distinct NDV genotypes are currently causing outbreaks ... -
A large screen identifies beta-lactam antibiotics which can be repurposed to target the syphilis agent
(Springer Nature, 2023)Syphilis, caused by the spirochete Treponema pallidum subsp. pallidum (hereafter called T. pallidum), is re-emerging as a worldwide sexually transmitted infection. A single intramuscular dose of benzathine penicillin G is ... -
Recent Population Dynamics of Japanese Encephalitis Virus
(MDPI, 2023-06-02)Japanese encephalitis virus (JEV) causes acute viral encephalitis in humans and reproductive disorders in pigs. JEV emerged during the 1870s in Japan, and since that time, JEV has been transmitted exclusively throughout ... -
The influence of SARS-CoV-2 infection on expression of drug-metabolizing enzymes and transporters in a hACE2 murine model
(Wiley, 2023-06)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting Coronavirus disease 2019 emerged in late 2019 and is responsible for significant morbidity and mortality worldwide. A hallmark of ... -
Spatiotemporal and meteorological relationships in dengue transmission in the Dominican Republic, 2015–2019
(2023-06-02)Dengue has broadened its global distribution substantially in the past two decades, and many endemic areas are experiencing increases in incidence. The Dominican Republic recently experienced its two largest outbreaks to ... -
Rift Valley fever virus Gn V5-epitope tagged virus enables identification of UBR4 as a Gn interacting protein that facilitates Rift Valley fever virus production
(Academic Press, 2022-02)Rift Valley fever virus (RVFV) is an arbovirus that was first reported in the Rift Valley of Kenya which causes significant disease in humans and livestock. RVFV is a tri-segmented, negative-sense RNA virus consisting of ... -
Climate change and infectious disease: a review of evidence and research trends
(2023-05-16)Background Climate change presents an imminent threat to almost all biological systems across the globe. In recent years there have been a series of studies showing how changes in climate can impact ... -
Two mutations in the ORF1 of genotype 1 hepatitis E virus enhance virus replication and may associate with fulminant hepatic failure
(National Academy of Sciences, 2022-08)Hepatitis E virus (HEV) infection in pregnant women has a high incidence of developing fulminant hepatic failure (FHF) with significant mortality. Multiple amino acid changes in genotype 1 HEV (HEV-1) are reportedly linked ... -
Soap application alters mosquito-host interactions
(Cell Press, 2023-05)To find nutrients, mosquitoes use volatile organic compounds (VOCs) emitted by plants and animal hosts. These resources overlap in their chemical composition, and an important layer of information resides in VOCs’ relative ... -
Phafins Are More Than Phosphoinositide-Binding Proteins
(MDPI, 2023-04-30)Phafins are PH (Pleckstrin Homology) and FYVE (Fab1, YOTB, Vac1, and EEA1) domain-containing proteins. The Phafin protein family is classified into two groups based on their sequence homology and functional similarity: ... -
Transmission risk of Oropouche fever across the Americas
(2023-05-06)Background Vector-borne diseases (VBDs) are important contributors to the global burden of infectious diseases due to their epidemic potential, which can result in significant population and economic ... -
Steelhead trout (Oncorhynchus mykiss) fed probiotic during the earliest developmental stages have enhanced growth rates and intestinal microbiome bacterial diversity
(Frontiers, 2022-11)Sustainable aquaculture practices can help meet the increasing human demand for seafood, while easing pressures on natural fish populations. Studies aimed at increasing fish production in aquaculture have included supplementary ... -
Discovery of Two Inhibitors of the Type IV Pilus Assembly ATPase PilB as Potential Antivirulence Compounds
(American Society for Microbiology, 2022-12)Many bacterial pathogens use their type IV pilus (T4P) to facilitate and maintain an infection in a human host. Small-molecule inhibitors of the production or assembly of the T4P are promising for the treatment and prevention ...
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