A variable-complexity design strategy with combined aerodynamic and structural optimization procedures is presented for the high speed civil transport design (HSCT). Variable-complexity analysis methods are used to reduce the computational expense. A finite element-model based structural optimization procedure with flexible loads is implemented to evaluate the wing bending material weight. Static aeroelastic effects, evaluated through the comparison of rigid and flexible wing models, are found to be small in the HSCT design. The results of structural optimization are compared with two quasi-empirical weight equations. Good correlation is obtained between the structural optimization and one of the weight equations. Based on this comparison, an interlacing procedure is developed to combine both the simple weight equations and structural optimization in the HSCT design optimization, at modest computational cost. HSCT designs based on the interlacing procedure reveal that the aerodynamic optimizer may take advantage of weaknesses in weight equation. However, the optimizer may be unable to escape the local minimum due to the noisy of aerodynamic response and the lack of derivative information for the interlacing procedure.