Investigating dielectric properties of different stages of syngeneic murine ovarian cancer cells
Sano, Michael B.
Gallo-Villanueva, R. C.
Roberts, Paul C.
Schmelz, Eva M.
Davalos, Rafael V.
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In this study, the electrical properties of four different stages of mouse ovarian surface epithelial (MOSE) cells were investigated using contactless dielectrophoresis (cDEP). This study expands the work from our previous report describing for the first time the crossover frequency and cell specific membrane capacitance of different stages of cancer cells that are derived from the same cell line. The specific membrane capacitance increased as the stage of malignancy advanced from 15.39 +/- 1.54 mF m(-2) for a non-malignant benign stage to 26.42 +/- 1.22 mF m(-2) for the most aggressive stage. These differences could be the result of morphological variations due to changes in the cytoskeleton structure, specifically the decrease of the level of actin filaments in the cytoskeleton structure of the transformed MOSE cells. Studying the electrical properties of MOSE cells provides important information as a first step to develop cancer-treatment techniques which could partially reverse the cytoskeleton disorganization of malignant cells to a morphology more similar to that of benign cells. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4788921] Actual pdf downloaded from NCBI.
- Destination Area: Global Systems Science (GSS) 
- Scholarly Works, Department of Biomedical Engineering and Mechanics 
- Scholarly Works, Department of Biomedical Sciences and Pathobiology 
- Scholarly Works, Department of Human Nutrition, Foods, and Exercise 
- Scholarly Works, Institute for Critical Technology and Applied Science (ICTAS) 
- Scholarly Works, School of Biomedical Engineering and Sciences