Show simple item record

dc.contributorVirginia Tech. Engineering Science and Mechanics Departmenten_US
dc.contributor.authorSkandani, Amir A.en_US
dc.contributor.authorAl-Haik, Marwan S.en_US
dc.identifier.citationSkandani, A. A., & Al-Haik, M. (2013). Reciprocal effects of the chirality and the surface functionalization on the drug delivery permissibility of carbon nanotubes. Soft Matter, 9(48), 11645-11649. doi: 10.1039/C3SM52126E
dc.description.abstractThe drug delivery admissibility of nanomaterials such as carbon nanotubes and their uncertain interactions with live tissues and organs have sparked ongoing research efforts. To boost the selective diffusivity of single walled carbon nanotubes (SWCNTs), surface functionalization was adopted in several experimental attempts. Numerous studies had identified polyethylene glycol (PEG) as a bio-compatible surfactant to carbon nanotubes. In this study, a large scale, atomistic molecular dynamic simulation was utilized to disclose the cellular exposure and uptake mechanisms of PEG-functionalized single walled carbon nanotubes (f-SWCNTs) into a lipid bilayer cell membrane. Results showed that with PEGs attached to a SWCNT, the penetration depth and speed can be controlled. Also, the simulations revealed that the adhesion energy between the nanotube and the lipid membrane is affected considerably, in the presence of PEGs, by the chirality of the SWCNTs.
dc.publisherThe Royal Society of Chemistry
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unported
dc.subjectCarbon nanotubesen_US
dc.subjectDrug delivery mechanismsen_US
dc.subjectSingle-walled carbon nanotubesen_US
dc.titleReciprocal effects of the chirality and the surface functionalization on the drug delivery permissibility of carbon nanotubesen_US
dc.typeArticle - Refereeden_US
dc.title.serialSoft Matter

Files in this item


This item appears in the following Collection(s)

Show simple item record

Creative Commons Attribution-NonCommercial 3.0 Unported
License: Creative Commons Attribution-NonCommercial 3.0 Unported