Virginia Tech
    • Log in
    View Item 
    •   VTechWorks Home
    • College of Engineering (COE)
    • Department of Biomedical Engineering and Mechanics
    • Scholarly Works, Department of Biomedical Engineering and Mechanics
    • View Item
    •   VTechWorks Home
    • College of Engineering (COE)
    • Department of Biomedical Engineering and Mechanics
    • Scholarly Works, Department of Biomedical Engineering and Mechanics
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Numerical investigation of flow-through immunoassay in a microchannel

    Thumbnail
    View/Open
    2010_Numerical_investigation_of_flow_through.pdf (903.5Kb)
    Downloads: 285
    Date
    2010-02-01
    Author
    Sinha, Ashok
    Ganguly, Ranjan
    Puri, Ishwar K.
    Metadata
    Show full item record
    Abstract
    Immunomagnetic separation (IMS) is a method to isolate biomaterials from a host fluid in which specifically selected antibodies attached to magnetic particles bind with their corresponding antigens on the surface of the target biological entities. A magnet separates these entities from the fluid through magnetophoresis. The method has promising applications in microscale biosensors. We develop a comprehensive model to characterize the interaction between target species and magnetic particles in microfluidic channels. The mechanics of the separation of target nonmagnetic N particles by magnetic M particles are investigated using a particle dynamics simulation. We consider both interparticle magnetic interactions and the binding of the functionalizing strands of complementary particles. The temporal growth of a particle aggregate and the relative concentrations of M and N particles are investigated under different operating conditions. A particle aggregate first grows and then exhibits periodic washaway about a quasisteady mean size. The washaway frequency and amplitude depend on the initial fractional concentration of N particles while the aggregate size scales linearly with the dipole strength and inversely with the fluid flow rate.
    URI
    http://hdl.handle.net/10919/52885
    Collections
    • Scholarly Works, Department of Biomedical Engineering and Mechanics [409]

    If you believe that any material in VTechWorks should be removed, please see our policy and procedure for Requesting that Material be Amended or Removed. All takedown requests will be promptly acknowledged and investigated.

    Virginia Tech | University Libraries | Contact Us
     

     

    VTechWorks

    AboutPoliciesHelp

    Browse

    All of VTechWorksCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Log inRegister

    Statistics

    View Usage Statistics

    If you believe that any material in VTechWorks should be removed, please see our policy and procedure for Requesting that Material be Amended or Removed. All takedown requests will be promptly acknowledged and investigated.

    Virginia Tech | University Libraries | Contact Us