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dc.contributorVirginia Tech. Engineering Science and Mechanics Departmenten_US
dc.contributorJadavpur University. Department of Power Engineeringen_US
dc.contributor.authorSinha, Ashoken_US
dc.contributor.authorGanguly, Ranjanen_US
dc.contributor.authorPuri, Ishwar K.en_US
dc.date.accessioned2015-06-01T16:10:47Z
dc.date.available2015-06-01T16:10:47Z
dc.date.issued2010-02-01
dc.identifier.citationSinha, A., Ganguly, R., Puri, I. K. (2010). Numerical investigation of flow-through immunoassay in a microchannel. Journal of Applied Physics, 107(3). doi: 10.1063/1.3284077en_US
dc.identifier.issn0021-8979en_US
dc.identifier.urihttp://hdl.handle.net/10919/52885
dc.description.abstractImmunomagnetic separation (IMS) is a method to isolate biomaterials from a host fluid in which specifically selected antibodies attached to magnetic particles bind with their corresponding antigens on the surface of the target biological entities. A magnet separates these entities from the fluid through magnetophoresis. The method has promising applications in microscale biosensors. We develop a comprehensive model to characterize the interaction between target species and magnetic particles in microfluidic channels. The mechanics of the separation of target nonmagnetic N particles by magnetic M particles are investigated using a particle dynamics simulation. We consider both interparticle magnetic interactions and the binding of the functionalizing strands of complementary particles. The temporal growth of a particle aggregate and the relative concentrations of M and N particles are investigated under different operating conditions. A particle aggregate first grows and then exhibits periodic washaway about a quasisteady mean size. The washaway frequency and amplitude depend on the initial fractional concentration of N particles while the aggregate size scales linearly with the dipole strength and inversely with the fluid flow rate.en_US
dc.format.extent7 pagesen_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_USen_US
dc.publisherAmerican Institute of Physicsen_US
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectIon-mobility spectrometryen_US
dc.subjectMicrofluidicsen_US
dc.subjectBiophysical techniquesen_US
dc.subjectCollision theoriesen_US
dc.subjectMagnetic fieldsen_US
dc.titleNumerical investigation of flow-through immunoassay in a microchannelen_US
dc.typeArticle - Refereeden_US
dc.contributor.departmentBiomedical Engineering and Mechanicsen_US
dc.identifier.urlhttp://scitation.aip.org/content/aip/journal/jap/107/3/10.1063/1.3284077en_US
dc.date.accessed2015-04-24en_US
dc.title.serialJournal of Applied Physicsen_US
dc.identifier.doihttps://doi.org/10.1063/1.3284077
dc.type.dcmitypeTexten_US


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