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    Expression of a heterologous protein C in mammary tissue of transgenic animals using a long whey acidic protein promoter

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    6262336.pdf (2.732Mb)
    Downloads: 55
    Publication Date
    2001-07-17
    Filing Date
    1999-05-28
    Inventor
    Drohan, William N.
    Velander, William H.
    Lubon, Henryk
    Hennighausen, Lothar
    Metadata
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    Abstract
    An isolated DNA sequence which regulates the expression of a heterologous gene composed of a mouse whey acidic protein promoter having a length of greater than about 2.4 kb extending upstream from the unique KpnI site in the mouse whey acidic protein gene is disclosed. Specifically a mouse whey acidic protein promoter of about 4.1-4.2 kb in length extending upstream from the unique KpnI site is preferred. This mouse whey acid protein promoter is operably linked to a DNA sequence encoding a heterologous polypeptide and used to prepare transgenic non-human mammals expressing the heterologous polypeptide in their milk. Particularly efficient expression of both cDNAs and genomic DNAs encoding heterologous polypeptides was obtained in transgenic non-human mammals using this promoter, known as the long whey acidic protein promoter.
    Assignee
    The American Red Cross
    Virginia Tech Intellectual Properties, Inc.
    The United States of America as represented by the Department of Health and Human Services
    Patent Number
    6262336
    Application Number
    9321831
    Source URL
    http://pimg-fpiw.uspto.gov/fdd/36/623/062/0.pdf
    Primary/U.S. Class
    536/24.1
    Other/U.S. Class
    800/14
    800/7
    800/15
    800/16
    800/17
    800/18
    CPC Class
    A01K67/0275
    A01K2207/15
    A01K2217/00
    A01K2217/05
    A01K2227/10
    A01K2227/105
    A01K2227/108
    A01K2267/01
    A61K38/00
    C07K14/75
    C07K2319/00
    C07K2319/02
    C12N15/8509
    C12N9/6464
    C12Y304/21069
    C12N2830/008
    Patent Type
    utility
    URI
    http://hdl.handle.net/10919/72432
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