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dc.contributor.authorWolozny Gomez Robelo, Daniel Andreen_US
dc.date.accessioned2016-10-19T08:00:13Z
dc.date.available2016-10-19T08:00:13Z
dc.date.issued2016-10-18en_US
dc.identifier.othervt_gsexam:9038en_US
dc.identifier.urihttp://hdl.handle.net/10919/73295
dc.description.abstractAdditive manufacturing in the form of 3D printing is a revolutionary technology that has developed within the last two decades. Its ability to print an object with accurate features down to the micro scale have made its use in medical devices and research feasible. A range of life-saving technologies can now go from the laboratory and into field with the application of 3D-printing. This technology can be applied to medical diagnosis of patients in at-risk populations. Living biosensors are limited by being Genetically Modified Organisms (GMOs) from being employed for medical diagnosis. However, by containing them within a 3D-printed enclosure, these technologies can serve as a vehicle to translate life-saving diagnosis technologies from the laboratory and into the field where the lower cost would allow more people to benefit from inexpensive diagnosis. Also, the GMO biosensors would be contained with a press-fit, ensuring that the living biosensors are unable to escape into the environment without user input. In addition, 3D-printing can also be applied to reduce the cost of lab-based technologies. Cell patterning technology is a target of interest for applying more cost-effective technologies, as elucidation of the variables defining cell patterning and motility may help explain the mechanics of cancer and other diseases. Through the use of a 3D-printed stamp, bacterial cells can be patterning without the use of a clean room, thus lowering the entry-barrier for researchers to explore cell patterning. With the commercialization of 3D-printing an opportunity has arisen to transition life-saving technologies into more cost-effective versions of existing technologies. This would not only allow more research into existing fields, but also to ensure that potentially life-saving technologies reach the people that need them.en_US
dc.format.mediumETDen_US
dc.publisherVirginia Techen_US
dc.rightsThis Item is protected by copyright and/or related rights. Some uses of this Item may be deemed fair and permitted by law even without permission from the rights holder(s), or the rights holder(s) may have licensed the work for use under certain conditions. For other uses you need to obtain permission from the rights holder(s).en_US
dc.subjectSynthetic biologyen_US
dc.subjectbiosensoren_US
dc.subject3D-printingen_US
dc.subjectGMOen_US
dc.subjectbacterial patterningen_US
dc.titleAdditive Manufacturing for Robust and Affordable Medical Devicesen_US
dc.typeDissertationen_US
dc.contributor.departmentBiological Systems Engineeringen_US
dc.description.degreePh. D.en_US
thesis.degree.namePh. D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineBiological Systems Engineeringen_US
dc.contributor.committeechairRuder, Warren Christopheren_US
dc.contributor.committeememberBashor, Caleb Jayen_US
dc.contributor.committeememberZhang, Chenmingen_US
dc.contributor.committeememberFeng, Xueyangen_US


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