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dc.contributor.authorHancioglu, Barisen
dc.contributor.authorTyson, John J.en
dc.date.accessioned2016-12-09T21:37:43Zen
dc.date.available2016-12-09T21:37:43Zen
dc.date.issued2012-02-23en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://hdl.handle.net/10919/73638en
dc.description.abstractCell cycle progression in eukaryotes is regulated by periodic activation and inactivation of a family of cyclin–dependent kinases (Cdk’s). Entry into mitosis requires phosphorylation of many proteins targeted by mitotic Cdk, and exit from mitosis requires proteolysis of mitotic cyclins and dephosphorylation of their targeted proteins. Mitotic exit in budding yeast is known to involve the interplay of mitotic kinases (Cdk and Polo kinases) and phosphatases (Cdc55/PP2A and Cdc14), as well as the action of the anaphase promoting complex (APC) in degrading specific proteins in anaphase and telophase. To understand the intricacies of this mechanism, we propose a mathematical model for the molecular events during mitotic exit in budding yeast. The model captures the dynamics of this network in wild-type yeast cells and 110 mutant strains. The model clarifies the roles of Polo-like kinase (Cdc5) in the Cdc14 early anaphase release pathway and in the G-protein regulated mitotic exit network.en
dc.format.extent? - ? (16) page(s)en
dc.languageEnglishen
dc.publisherPLOSen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000302916100009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectANAPHASE-PROMOTING COMPLEXen
dc.subjectQUANTIZED CYCLE TIMESen
dc.subjectCELL-CYCLEen
dc.subjectSACCHAROMYCES-CEREVISIAEen
dc.subjectCDC14 RELEASEen
dc.subjectFISSION YEASTen
dc.subjectM-PHASEen
dc.subjectPHOSPHATASE CDC14en
dc.subjectSPINDLE CHECKPOINTen
dc.subjectDNA-REPLICATIONen
dc.titleA Mathematical Model of Mitotic Exit in Budding Yeast: The Role of Polo Kinaseen
dc.typeArticle - Refereeden
dc.description.versionPublished versionen
dc.contributor.departmentBiological Sciencesen
dc.title.serialPLOS ONEen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0030810en
dc.identifier.volume7en
dc.identifier.issue2en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Biological Sciencesen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Distinguished Professorsen


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License: Creative Commons Attribution 4.0 International