Show simple item record

dc.contributor.authorPhilipson, Casandra Washingtonen
dc.date.accessioned2017-01-19T07:00:11Zen
dc.date.available2017-01-19T07:00:11Zen
dc.date.issued2015-07-28en
dc.identifier.othervt_gsexam:6127en
dc.identifier.urihttp://hdl.handle.net/10919/74392en
dc.description.abstractDuring acute and chronic infectious diseases hosts develop complex immune responses to cope with bacterial persistence. Depending on a variety of host and microbe factors, outcomes range from peaceful co-existence to detrimental disease. Mechanisms underlying immunity to bacterial stimuli span several spatiotemporal magnitudes and the summation of these hierarchical interactions plays a decisive role in pathogenic versus tolerogenic fate for the host. This dissertation integrates diverse data from immunoinformatics analyses, experimental validation and mathematical modeling to investigate a series of hypotheses driven by computational modeling to study mucosal immunity. Two contrasting microbes, enteroaggregative Escherichia coli and Helicobacter pylori, are used to perturb gut immunity in order to discover host-centric targets for modulating the host immune system. These findings have the potential to be broadly applicable to other infectious and immune-mediated diseases and could assist in the development of antibiotic-free and host-targeted treatments that modulate tolerance to prevent disease.en
dc.format.mediumETDen
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectGut inflammationen
dc.subjectEnteroaggregative Escherichia colien
dc.subjectHelicobacter pylorien
dc.subjectcomputational modelingen
dc.subjectimmunologyen
dc.subjectimmunoinformaticsen
dc.titleSystems analysis and characterization of mucosal immunityen
dc.typeDissertationen
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.description.degreePh. D.en
thesis.degree.namePh. D.en
thesis.degree.leveldoctoralen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.disciplineGenetics, Bioinformatics, and Computational Biologyen
dc.contributor.committeechairBassaganya-Riera, Josepen
dc.contributor.committeememberHoops, Stefanen
dc.contributor.committeememberHontecillas-Magarzo, Raquelen
dc.contributor.committeememberAllen, Irving C.en


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record