Destination Areas provide faculty and students with new tools to identify and solve complex, 21st-century problems in which Virginia Tech already has significant strengths and can take a global leadership role. The initiative represents the next step in the evolution of the land-grant university to meet economic and societal needs of the world. DAs connect the full span of relevant knowledge necessary for addressing issues comprehensively. Humanistic, scientific, and technological perspectives are addressed in relationship to one another and they are treated as complementary to overcome traditional academic boundaries, such as those that separate the STEM fields and liberal arts. [http://provost.vt.edu/destination-areas.html]

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Recent Submissions

  • An Early Event in Adipogenesis, the Nuclear Selection of the CCAAT Enhancer-binding Protein ß (C/EBP ß ) mRNA by HuR and its Translocation to the Cytosol2006 

    Gantt, Kira (American Society for Biochemistry and Molecular Biology, 2006-07)
    HuR is a ligand for nuclear mRNAs containing adenylate-uridylate-rich elements in the 3_-untranslated region. Once bound to the mRNA, HuR is recognized by adapter proteins that then facilitate nuclear export of the complex. ...
  • Neuroimaging after mild traumatic brain injury: Review and meta-analysis 

    Eierud, Cyrus; Craddock, R. Cameron; Fletcher, Sean; Aulakh, Manek; King-Casas, Brooks; Kuehl, Damon; LaConte, Stephen M. (Elsevier, 2014-01-04)
    This paper broadly reviews the study of mild traumatic brain injury (mTBI), across the spectrum of neuroimaging modalities. Among the range of imaging methods, however, magnetic resonance imaging (MRI) is unique in its ...
  • Psychosocial and Computer-Assisted Intervention for College Students with Autism Spectrum Disorder: Preliminary Support for Feasibility 

    White, Susan W.; Richey, John A.; Gracanin, Denis; Coffman, Marika; Elias, Rebecca; LaConte, Stephen; Ollendick, Thomas H. (The Council for Exceptional Children, Division on Autism and Developmental Disabilities, 2016-09)
    The number of young adults with Autism Spectrum Disorders (ASD) enrolled in higher education institutions has steadily increased over the last decade. Despite this, there has been little research on how to most effectively ...
  • Countering the Cyber Threat 

    Brantly, AF; Henry, S (The Army Cyber Institute, 2018-05-09)
  • Temperature Effects Explain Continental Scale Distribution of Cyanobacterial Toxins 

    Mantzouki, Evanthia; Lürling, Miquel; Fastner, Jutta; de Senerpont Domis, Lisette; Wilk-Woźniak, Elżbieta; Koreivienė, Judita; Seelen, Laura; Teurlincx, Sven; Verstijnen, Yvon; Krztoń, Wojciech; Walusiak, Edward; Karosienė, Jūratė; Kasperovičienė, Jūratė; Savadova, Ksenija; Vitonytė, Irma; Cillero-Castro, Carmen; Budzyńska, Agnieszka; Goldyn, Ryszard; Kozak, Anna; Rosińska, Joanna; Szeląg-Wasielewska, Elżbieta; Domek, Piotr; Jakubowska-Krepska, Natalia; Kwasizur, Kinga; Messyasz, Beata; Pełechata, Aleksandra; Pełechaty, Mariusz; Kokocinski, Mikolaj; García-Murcia, Ana; Real, Monserrat; Romans, Elvira; Noguero-Ribes, Jordi; Duque, David Parreño; Fernández-Morán, Elísabeth; Karakaya, Nusret; Häggqvist, Kerstin; Demir, Nilsun; Beklioğlu, Meryem; Filiz, Nur; Levi, Eti E.; Iskin, Uğur; Bezirci, Gizem; Tavşanoğlu, Ülkü Nihan; Özhan, Koray; Gkelis, Spyros; Panou, Manthos; Fakioglu, Özden; Avagianos, Christos; Kaloudis, Triantafyllos; Çelik, Kemal; Yilmaz, Mete; Marcé, Rafael; Catalán, Nuria; Bravo, Andrea G.; Buck, Moritz; Colom-Montero, William; Mustonen, Kristiina; Pierson, Don; Yang, Yang; Raposeiro, Pedro M.; Gonçalves, Vítor; Antoniou, Maria G.; Tsiarta, Nikoletta; McCarthy, Valerie; Perello, Victor C.; Feldmann, Tõnu; Laas, Alo; Panksep, Kristel; Tuvikene, Lea; Gagala, Ilona; Mankiewicz-Boczek, Joana; Yağcı, Meral Apaydın; Çınar, Şakir; Çapkın, Kadir; Yağcı, Abdulkadir; Cesur, Mehmet; Bilgin, Fuat; Bulut, Cafer; Uysal, Rahmi; Obertegger, Ulrike; Boscaini, Adriano; Flaim, Giovanna; Salmaso, Nico; Cerasino, Leonardo; Richardson, Jessica; Visser, Petra M.; Verspagen, Jolanda M. H.; Karan, Tünay; Soylu, Elif Neyran; Maraşlıoğlu, Faruk; Napiórkowska-Krzebietke, Agnieszka; Ochocka, Agnieszka; Pasztaleniec, Agnieszka; Antão-Geraldes, Ana M.; Vasconcelos, Vitor; Morais, João; Vale, Micaela; Köker, Latife; Akçaalan, Reyhan; Albay, Meriç; Špoljarić Maronić, Dubravka; Stević, Filip; Žuna Pfeiffer, Tanja; Fonvielle, Jeremy; Straile, Dietmar; Rothhaupt, Karl-Otto; Hansson, Lars-Anders; Urrutia-Cordero, Pablo; Bláha, Luděk; Geriš, Rodan; Fránková, Markéta; Koçer, Mehmet Ali Turan; Alp, Mehmet Tahir; Remec-Rekar, Spela; Elersek, Tina; Triantis, Theodoros; Zervou, Sevasti-Kiriaki; Hiskia, Anastasia; Haande, Sigrid; Skjelbred, Birger; Madrecka, Beata; Nemova, Hana; Drastichova, Iveta; Chomova, Lucia; Edwards, Christine; Sevindik, Tuğba Ongun; Tunca, Hatice; Önem, Burçin; Aleksovski, Boris; Krstić, Svetislav; Vucelić, Itana Bokan; Nawrocka, Lidia; Salmi, Pauliina; Machado-Vieira, Danielle; de Oliveira, Alinne Gurjão; Delgado-Martín, Jordi; García, David; Cereijo, Jose Luís; Gomà, Joan; Trapote, Mari Carmen; Vegas-Vilarrúbia, Teresa; Obrador, Biel; Grabowska, Magdalena; Karpowicz, Maciej; Chmura, Damian; Úbeda, Bárbara; Gálvez, José Ángel; Özen, Arda; Christoffersen, Kirsten Seestern; Warming, Trine Perlt; Kobos, Justyna; Mazur-Marzec, Hanna; Pérez-Martínez, Carmen; Ramos-Rodríguez, Eloísa; Arvola, Lauri; Alcaraz-Párraga, Pablo; Toporowska, Magdalena; Pawlik-Skowronska, Barbara; Niedźwiecki, Michał; Pęczuła, Wojciech; Leira, Manel; Hernández, Armand; Moreno-Ostos, Enrique; Blanco, José María; Rodríguez, Valeriano; Montes-Pérez, Jorge Juan; Palomino, Roberto L.; Rodríguez-Pérez, Estela; Carballeira, Rafael; Camacho, Antonio; Picazo, Antonio; Rochera, Carlos; Santamans, Anna C.; Ferriol, Carmen; Romo, Susana; Soria, Juan Miguel; Dunalska, Julita; Sieńska, Justyna; Szymański, Daniel; Kruk, Marek; Kostrzewska-Szlakowska, Iwona; Jasser, Iwona; Žutinić, Petar; Gligora Udovič, Marija; Plenković-Moraj, Anđelka; Frąk, Magdalena; Bańkowska-Sobczak, Agnieszka; Wasilewicz, Michał; Özkan, Korhan; Maliaka, Valentini; Kangro, Kersti; Grossart, Hans-Peter; Paerl, Hans W.; Carey, Cayelan C.; Ibelings, Bas W. (MDPI, 2018-04-13)
    Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing ...
  • Evaluating Geologic Sources of Arsenic in Well Water in Virginia (USA) 

    VanDerwerker, Tiffany; Zhang, Lin; Ling, Erin; Benham, Brian; Schreiber, Madeline (MDPI, 2018-04-18)
    We investigated if geologic factors are linked to elevated arsenic (As) concentrations above 5 μg/L in well water in the state of Virginia, USA. Using geologic unit data mapped within GIS and two datasets of measured ...
  • Community Earth System Model Simulations Reveal the Relative Importance of Afforestation and Forest Management to Surface Temperature in Eastern North America 

    Ahlswede, Benjamin J.; Thomas, R. Quinn (MDPI, 2017-12-13)
    Afforestation changes the land surface energy balance, though the effects on climate in temperate regions is uncertain, particularly the changes associated with forest management. In this study, we used idealized Community ...
  • Understanding Long-Term Variations in Surface Ozone in United States (U.S.) National Parks 

    McGlynn, Deborah; Mao, Huiting; Wu, Zhaohua; Sive, Barkley; Sharac, Timothy (MDPI, 2018-03-25)
    Long-term surface ozone observations at 25 National Park Service sites across the United States were analyzed for processes on varying time scales using a time scale decomposition technique, the Ensemble Empirical Mode ...
  • Water Temperature, pH, and Road Salt Impacts on the Fluvial Erosion of Cohesive Streambanks 

    Hoomehr, Siavash; Akinola, Akinrotimi I.; Wynn-Thompson, Theresa; Garnand, Waverly; Eick, Matthew J. (MDPI, 2018-03-10)
    Increasing human populations and global climate change will severely stress our water resources. One potential unforeseen consequence of these stressors is accelerated stream channel erosion due to increased stream ...
  • Sex, stress, and epigenetics: regulation of behavior in animal models of mood disorders 

    Hodes, Georgia E. (BMC, 2013)
    Women have a higher incidence of stress related disorders including depression and generalized anxiety disorder, and epigenetic mechanisms likely contribute to this sex difference. Evidence from preclinical research suggests ...
  • Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice 

    Wang, Jun; Hodes, Georgia E.; et al (Nature, 2018)
    Major depressive disorder is associated with abnormalities in the brain and the immune system. Chronic stress in animals showed that epigenetic and inflammatory mechanisms play important roles in mediating resilience and ...
  • A Statistical Framework for the Adaptive Management of Epidemiological Interventions 

    Merl, Daniel; Johnson, Leah R.; Gramacy, Robert B.; Mangel, Marc (PLOS, 2009)
    Background: Epidemiological interventions aim to control the spread of infectious disease through various mechanisms, each carrying a different associated cost. Methodology: We describe a flexible statistical framework for ...
  • Understanding uncertainty in temperature effects on vector-borne disease: a Bayesian approach 

    Johnson, Leah R.; Ben-Horin, Tal; Lafferty, Kevin D.; McNally, Amy; Mordecai, Erin; Paaijmans, Krijn P.; Pawar, Samraat; Ryan, Sadie J. (Ecological Society of America, 2015)
    Extrinsic environmental factors influence the distribution and population dynamics of many organisms, including insects that are of concern for human health and agriculture. This is particularly true for vector-borne ...
  • HOMER: An Interactive System for Home Based Stroke Rehabilitation 

    Kelliher, Aisling; Choi, Jinwoo; Huang, Jia-Bin; Rikakis, Thanassis; Kitani, Kris (ACM, 2017)
    Delivering long term, unsupervised stroke rehabilitation in the home is a complex challenge that requires robust, low cost, scalable, and engaging solutions. We present HOMER, an interactive system that uses novel therapy ...
  • Problematic Roadway Environments for Automated Vehicles 

    Terry, Travis N.; Tanner, Stephen (National Surface Transportation Safety Center for Excellence, 2018-04-03)
    Progress in the area of automated vehicles (AVs) will benefit safety, mobility, and environmental sustainability. Of the roughly 30,000 traffic-related fatalities reported yearly, 94% are due to human error. AVs replace ...
  • Privacy Preserving Network Security Data Analytics: Architectures and System Design 

    DeYoung, Mark E.; Kobezak, Philip; Raymond, David; Marchany, Randy; Tront, Joseph (University of Hawaii at Manoa, 2018-01-03)
    An incessant rhythm of data breaches, data leaks, and privacy exposure highlights the need to improve control over potentially sensitive data. History has shown that neither public nor private sector organizations are ...
  • Longitudinal associations among family environment, neural cognitive control, and social competence among adolescents 

    Kim-Spoon, Jungmeen; Maciejewski, Dominique; Lee, Jacob; Deater-Deckard, Kirby; King-Casas, Brooks (Elsevier, 2017-05-16)
    During adolescence, prefrontal cortex regions, important in cognitive control, undergo maturation to adapt to changing environmental demands. Ways through which social-ecological factors contribute to adolescent neural ...
  • Disparities in spread and control of influenza in slums of Delhi: findings from an agent-based modelling study 

    Adiga, Abhijin; et al (BMJ Publishing Group, 2017-11-03)
    Objectives: This research studies the role of slums in the spread and control of infectious diseases in the National Capital Territory of India, Delhi, using detailed social contact networks of its residents. Methods: ...
  • A Little Goes a Long Way: Low Working Memory Load Is Associated with Optimal Distractor Inhibition and Increased Vagal Control under Anxiety 

    Spangler, Derek P.; Friedman, Bruce H. (Frontiers, 2017-02-03)
    Anxiety impairs both inhibition of distraction and attentional focus. It is unclear whether these impairments are reduced or exacerbated when loading working memory with nonaffective information. Cardiac vagal control has ...
  • Spatiotemporal dissociation of brain activity underlying threat and reward in social anxiety disorder 

    Richey, John A.; Ghane, Merage; Valdespino, Andrew; Coffman, Marika C.; Strege, Marlene V.; White, Susan G.; Ollendick, Thomas H. (Oxford University Press, 2016-10-19)
    Social anxiety disorder (SAD) involves abnormalities in social motivation, which may be independent of well-documented differences in fear and arousal systems. Yet, the neurobiology underlying motivational difficulties in ...

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