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dc.contributor.authorDu, Yongleen_US
dc.date.accessioned2018-06-26T08:00:45Z
dc.date.available2018-06-26T08:00:45Z
dc.date.issued2018-06-25
dc.identifier.othervt_gsexam:15423en_US
dc.identifier.urihttp://hdl.handle.net/10919/83762
dc.description.abstractAs a part of search for bioactive natural products from the plants in collaboration with the Natural Products Discovery Institute (NPDI), ten plant extracts were investigated for their antiplasmodial activity against Plasmodium falciparum Dd2 strain. Twenty-eight compounds were isolated, and twelve of them were new compounds. The structures of all these compounds were determined by analysis of their mass spectrometric, 1D and 2D NMR, and ECD spectrum. Among these natural products, there were three compounds with good antiplasmodial activity, trichospirolide A with an IC50 value of 1.5 μM, malleastrumolide A with an IC50 value of 2.7 μM, and (+)-lariciresinol with an IC50 value of 3.7 μM. In addition to the studies of drug delivery of bioactive natural product, doxorubicin, a novel thiolated doxorubicin analog were designed and synthesized. Its analogs and PEG stabilizing ligands were then conjugated to gold nanoparticles and the resulting Au-Dox constructs were evaluated by TEM. The release of native drug can be achieved by the action of reducing agents, and that reductive drug release gave the cleanest drug release.en_US
dc.format.mediumETDen_US
dc.publisherVirginia Techen_US
dc.rightsThis item is protected by copyright and/or related rights. Some uses of this item may be deemed fair and permitted by law even without permission from the rights holder(s), or the rights holder(s) may have licensed the work for use under certain conditions. For other uses you need to obtain permission from the rights holder(s).en_US
dc.subjectNatural Productsen_US
dc.subjectAntiplasmodialen_US
dc.subjectAntiproliferativeen_US
dc.subjectSesquiterpenoiden_US
dc.subjectNeolignanen_US
dc.subjectDiterpenoiden_US
dc.subjectCoumarinen_US
dc.subjectButanolideen_US
dc.titleDiscovery and Delivery of Bioactive Natural Productsen_US
dc.typeDissertationen_US
dc.contributor.departmentChemistryen_US
dc.description.degreePh. D.en_US
thesis.degree.namePh. D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineChemistryen_US
dc.contributor.committeechairKingston, David G. I.en_US
dc.contributor.committeememberGandour, Richard D.en_US
dc.contributor.committeememberCarlier, Paul R.en_US
dc.contributor.committeememberSantos, Websteren_US


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