Comparing oxytocin and cortisol regulation in a double-blind, placebo-controlled, hydrocortisone challenge pilot study in children with autism and typical development

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dc.contributor.authorCorbett, Blythe A.en
dc.contributor.authorBales, Karen L.en
dc.contributor.authorSwain, Deanna M.en
dc.contributor.authorSanders, Kevin B.en
dc.contributor.authorWeinstein, Tamara A. R.en
dc.contributor.authorMuglia, Louis J.en
dc.contributor.departmentPsychologyen
dc.date.accessioned2019-05-28T14:50:20Zen
dc.date.available2019-05-28T14:50:20Zen
dc.date.issued2016-08-18en
dc.description.abstractChildren with autism spectrum disorder (ASD) show marked impairment in social functioning and poor adaptation to new and changing contexts, which may be influenced by underlying regulatory processes. Oxytocin (OT) and cortisol are key neuromodulators of biological and behavioral responses, show a synergistic effect, and have been implicated in the neuropathological profile in ASD. However, they are rarely investigated together. The purpose of the pilot study was to evaluate the relationship between cortisol and OT in children with ASD under baseline and physiological stress (hydrocortisone challenge) conditions. Arginine vasopressin (AVP), structurally similar to OT, was also examined.en
dc.description.sponsorshipNIH HHS (P51 OD011107) United States; NICHD NIH HHS (U54 HD083211) United States; NCATS NIH HHS (UL1 TR000445) United Statesen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1186/s11689-016-9165-6en
dc.identifier.issn1866-1947en
dc.identifier.issn1866-1955en
dc.identifier.issue1en
dc.identifier.pmid27540420en
dc.identifier.urihttp://hdl.handle.net/10919/89619en
dc.identifier.volume8en
dc.language.isoenen
dc.publisherSpringer New Yorken
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectArginine vasopressinen
dc.subjectAutismen
dc.subjectAutism spectrum disorderen
dc.subjectCortisolen
dc.subjectHormoneen
dc.subjectHydrocortisoneen
dc.subjectLHPA axisen
dc.subjectOxytocinen
dc.subjectStressen
dc.titleComparing oxytocin and cortisol regulation in a double-blind, placebo-controlled, hydrocortisone challenge pilot study in children with autism and typical developmenten
dc.title.serialJournal of Neurodevelopmental Disordersen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Destination Area: Adaptive Brain and Behavior (ABB)