Evidence of horizontal gene transfer and environmental selection impacting antibiotic resistance evolution in soil-dwelling Listeria

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dc.contributor.authorGoh, Ying-Xianen
dc.contributor.authorAnupoju, Sai Manohar Baluen
dc.contributor.authorNguyen, Anthonyen
dc.contributor.authorZhang, Hailongen
dc.contributor.authorPonder, Monica A.en
dc.contributor.authorKrometis, Leigh-Anne H.en
dc.contributor.authorPruden, Amyen
dc.contributor.authorLiao, Jingqiuen
dc.date.accessioned2024-12-12T19:44:32Zen
dc.date.available2024-12-12T19:44:32Zen
dc.date.issued2024-11-19en
dc.description.abstractSoil is an important reservoir of antibiotic resistance genes (ARGs) and understanding how corresponding environmental changes influence their emergence, evolution, and spread is crucial. The soil-dwelling bacterial genus Listeria, including L. monocytogenes, the causative agent of listeriosis, serves as a keymodel for establishing this understanding. Here, we characterize ARGs in 594 genomes representing 19 Listeria species that we previously isolated from soils in natural environments across the United States. Among the five putatively functional ARGs identified, lin,which confers resistance to lincomycin, is the most prevalent, followed by mprF, sul, fosX, and norB. ARGs are predominantly found in Listeria sensu stricto species, with those more closely related to L. monocytogenes tending to harbor more ARGs. Notably, phylogenetic and recombination analyses provide evidence of recent horizontal gene transfer (HGT) in all five ARGs within and/or across species, likelymediated by transformation rather than conjugation and transduction. In addition, the richness and genetic divergence of ARGs are associated with environmental conditions, particularly soil properties (e.g., aluminum and magnesium) and surrounding land use patterns (e.g., forest coverage). Collectively, our data suggest that recent HGT and environmental selection play a vital role in the acquisition and diversification of bacterial ARGs in natural environments.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/s41467-024-54459-9en
dc.identifier.urihttps://hdl.handle.net/10919/123783en
dc.identifier.volume15en
dc.language.isoenen
dc.publisherNature Researchen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.titleEvidence of horizontal gene transfer and environmental selection impacting antibiotic resistance evolution in soil-dwelling <i>Listeria</i>en
dc.title.serialNature Communicationsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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