Real-Time Temperature Rise Estimation during Irreversible Electroporation Treatment through State-Space Modeling
| dc.contributor.author | Campelo, Sabrina N. | en |
| dc.contributor.author | Jacobs, Edward J. | en |
| dc.contributor.author | Aycock, Kenneth N. | en |
| dc.contributor.author | Davalos, Rafael V. | en |
| dc.date.accessioned | 2022-10-13T16:41:44Z | en |
| dc.date.available | 2022-10-13T16:41:44Z | en |
| dc.date.issued | 2022-09-23 | en |
| dc.date.updated | 2022-10-13T12:58:18Z | en |
| dc.description.abstract | To evaluate the feasibility of real-time temperature monitoring during an electroporation-based therapy procedure, a data-driven state-space model was developed. Agar phantoms mimicking low conductivity (LC) and high conductivity (HC) tissues were tested under the influences of high (HV) and low (LV) applied voltages. Real-time changes in impedance, measured by Fourier Analysis SpecTroscopy (FAST) along with the known tissue conductivity and applied voltages, were used to train the model. A theoretical finite element model was used for external validation of the model, producing model fits of 95.8, 88.4, 90.7, and 93.7% at 4 mm and 93.2, 58.9, 90.0, and 90.1% at 10 mm for the HV-HC, LV-LC, HV-LC, and LV-HC groups, respectively. The proposed model suggests that real-time temperature monitoring may be achieved with good accuracy through the use of real-time impedance monitoring. | en |
| dc.description.version | Published version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Campelo, S.N.; Jacobs, E.J., IV; Aycock, K.N.; Davalos, R.V. Real-Time Temperature Rise Estimation during Irreversible Electroporation Treatment through State-Space Modeling. Bioengineering 2022, 9, 499. | en |
| dc.identifier.doi | https://doi.org/10.3390/bioengineering9100499 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/112141 | en |
| dc.language.iso | en | en |
| dc.publisher | MDPI | en |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | pulsed field ablation | en |
| dc.subject | PFA | en |
| dc.subject | electroporation | en |
| dc.subject | H-FIRE | en |
| dc.subject | thermal mitigation | en |
| dc.subject | temperature prediction | en |
| dc.subject | black-box modeling | en |
| dc.subject | agar phantom | en |
| dc.title | Real-Time Temperature Rise Estimation during Irreversible Electroporation Treatment through State-Space Modeling | en |
| dc.title.serial | Bioengineering | en |
| dc.type | Article - Refereed | en |
| dc.type.dcmitype | Text | en |