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Digital Spectral Separation Methods And Systems For Bioluminescence Imaging

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dc.contributor.authorWang, Geen
dc.contributor.authorShen, Haiouen
dc.contributor.authorLiu, Y.en
dc.contributor.authorCong, A.en
dc.contributor.authorCong, W. X.en
dc.contributor.authorWang, Y.en
dc.contributor.authorDubey, P.en
dc.contributor.departmentElectrical and Computer Engineeringen
dc.contributor.departmentSchool of Biomedical Engineering and Sciencesen
dc.date.accessed2014-02-24en
dc.date.accessioned2014-04-04T15:12:14Zen
dc.date.available2014-04-04T15:12:14Zen
dc.date.issued2008-01-01en
dc.description.abstractWe propose a digital spectral separation (DSS) system and methods to extract spectral information optimally from a weak multispectral signal such as in the bioluminescent imaging (BLI) studies. This system utilizes our newly invented spatially-translated spectral-image mixer (SSM), which consists of dichroic beam splitters, a mirror, and a DSS algorithm. The DSS approach overcomes the shortcomings of the data acquisition scheme used for the current BLI systems. Primarily, using our DSS scheme, spectral information will not be filtered out. Accordingly, truly parallel multi-spectral multi-view acquisition is enabled for the first time to minimize experimental time and optimize data quality. This approach also permits recovery of the bioluminescent signal time course, which is useful to study the kinetics of multiple bioluminescent probes using multi-spectral bioluminescence tomography (MSBT).en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGe Wang, Haiou Shen, Ying Liu, Alex Cong, Wenxiang Cong, Yue Wang, and Purnima Dubey, "Digital spectral separation methods and systems for bioluminescence imaging," Opt. Express 16, 1719-1732 (2008). doi: 10.1364/oe.16.001719en
dc.identifier.doihttps://doi.org/10.1364/oe.16.001719en
dc.identifier.issn1094-4087en
dc.identifier.urihttp://hdl.handle.net/10919/46889en
dc.identifier.urlhttp://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-3-1719en
dc.language.isoenen
dc.publisherOptical Society of Americaen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectOptical tomographyen
dc.subjectEvolutionen
dc.titleDigital Spectral Separation Methods And Systems For Bioluminescence Imagingen
dc.title.serialOptics Expressen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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