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Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genes

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dc.contributor.authorBaroni, Mirellaen
dc.contributor.authorYi, Caihongen
dc.contributor.authorChoudhary, Saketen
dc.contributor.authorLei, Xiufenen
dc.contributor.authorKosti, Adamen
dc.contributor.authorGrieshober, Deniseen
dc.contributor.authorVelasco, Mitzlien
dc.contributor.authorQiao, Meien
dc.contributor.authorBurns, Suzanne S.en
dc.contributor.authorAraujo, Patricia R.en
dc.contributor.authorDeLambre, Taliaen
dc.contributor.authorSon, Mi Youngen
dc.contributor.authorPlateroti, Michelinaen
dc.contributor.authorFerreira, Marco A. R.en
dc.contributor.authorHasty, Paulen
dc.contributor.authorPenalva, Luiz O. F.en
dc.contributor.departmentStatisticsen
dc.date.accessioned2021-03-30T12:40:37Zen
dc.date.available2021-03-30T12:40:37Zen
dc.date.issued2021-03-24en
dc.date.updated2021-03-26T14:06:41Zen
dc.description.abstractRNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in their levels are often observed in tumors with numerous oncogenic RBPs identified in recent years. Musashi1 (Msi1) is an RBP and stem cell gene that controls the balance between self-renewal and differentiation. High Msi1 levels have been observed in multiple tumors including glioblastoma and are often associated with poor patient outcomes and tumor growth. A comprehensive genomic analysis identified a network of cell cycle/division and DNA replication genes and established these processes as Msi1’s core regulatory functions in glioblastoma. Msi1 controls this gene network via two mechanisms: direct interaction and indirect regulation mediated by the transcription factors E2F2 and E2F8. Moreover, glioblastoma lines with Msi1 knockout (KO) displayed increased sensitivity to cell cycle and DNA replication inhibitors. Our results suggest that a drug combination strategy (Msi1 + cell cycle/DNA replication inhibitors) could be a viable route to treat glioblastoma.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBaroni, M.; Yi, C.; Choudhary, S.; Lei, X.; Kosti, A.; Grieshober, D.; Velasco, M.; Qiao, M.; Burns, S.S.; Araujo, P.R.; DeLambre, T.; Son, M.Y.; Plateroti, M.; Ferreira, M.A.R.; Hasty, P.; Penalva, L.O.F. Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genes. Cancers 2021, 13, 1494.en
dc.identifier.doihttps://doi.org/10.3390/cancers13071494en
dc.identifier.urihttp://hdl.handle.net/10919/102883en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectglioblastomaen
dc.subjectMusashi1en
dc.subjectcell cycleen
dc.subjectDNA replicationen
dc.subjectcell divisionen
dc.subjectE2F2en
dc.subjectE2F8en
dc.titleMusashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genesen
dc.title.serialCancersen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, Statistics