Comparison of the mitral valve morphologies of Cavalier King Charles Spaniels and dogs of other breeds using 3D transthoracic echocardiography

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dc.contributor.authorMenciotti, Giulioen
dc.contributor.authorBorgarelli, Micheleen
dc.contributor.authorAherne, Michaelen
dc.contributor.authorCamacho, Paulaen
dc.contributor.authorHaggstrom, Jensen
dc.contributor.authorLjungvall, Ingriden
dc.contributor.authorLahmers, Sunshine M.en
dc.contributor.authorAbbott, Jonathan A.en
dc.date.accessioned2021-10-20T11:58:29Zen
dc.date.available2021-10-20T11:58:29Zen
dc.date.issued2018-09-01en
dc.date.updated2021-10-20T11:58:26Zen
dc.description.abstractBackground: Myxomatous mitral valve disease (MMVD) is more prevalent in Cavalier King Charles Spaniels (CKCSs) compared to dogs of other breeds at a given age. Abnormal valvular stress is thought to contribute to the development and progression of MMVD, and a relationship exists between mitral valve (MV) morphology and stress acting on the valve. Objectives: To determine whether the MV morphology of healthy adult CKCSs differs from the morphology of healthy adult dogs of other breeds determined by RT-3DTTE. Animals: Thirty-five healthy CKCSs and 41 healthy dogs of other breeds. Methods: Prospective cross-sectional study. Dogs underwent physical examination, conventional echocardiography, and RT-3DTTE. RT–3DTTE datasets were analyzed using dedicated software for MV morphologic analysis. Morphologic variables were compared between CKCSs and dogs of other breeds. Results: The MV of healthy CKCSs had a smaller annulus height (0.46 ± 0.11 vs. 0.56 ± 0.17; P =.0021), tenting height (0.26 ± 0.12 vs. 0.42 ± 0.18; P <.001), tenting area (0.42 ± 0.15 vs. 0.79 ± 0.34; P <.001), normalized tenting volume (0.09 [0.05–0.13] vs. 0.14 [0.10–0.20]; P <.001), and normalized area of the posterior leaflet (0.57 ± 0.15 vs. 0.66 ± 0.18; P =.016) compared to healthy dogs of other breeds; this results in CKCSs having a flatter MV with reduced tenting, compared to the MV of other breeds. Conclusions and Clinical Importance: These morphologic features could confer a mechanical disadvantage and play a role in the predisposition of CKCSs to the early development of MMVD.en
dc.description.versionPublished versionen
dc.format.extentPages 1564-1569en
dc.format.extent6 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/jvim.15252en
dc.identifier.eissn1939-1676en
dc.identifier.issn1939-1676en
dc.identifier.issue5en
dc.identifier.orcidLahmers, Sunshine [0000-0001-7967-0960]en
dc.identifier.orcidMenciotti, Giulio [0000-0001-7483-062X]en
dc.identifier.pmid30238697en
dc.identifier.urihttp://hdl.handle.net/10919/105422en
dc.identifier.volume32en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000447414300009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectLife Sciences & Biomedicineen
dc.subjectVeterinary Sciencesen
dc.subjectcanineen
dc.subjecthearten
dc.subjectimagingen
dc.subjectmyxomatousen
dc.subjectANNULOPLASTY RINGSen
dc.subjectLEAFLET CURVATUREen
dc.subjectANNULAR GEOMETRYen
dc.subjectHEALTHY DOGSen
dc.subjectDISEASEen
dc.subjectREGURGITATIONen
dc.subjectDEGENERATIONen
dc.subjectPROLAPSEen
dc.subjectSTRAINen
dc.subjectSHAPEen
dc.subject0707 Veterinary Sciencesen
dc.subject.meshMitral Valveen
dc.subject.meshAnimalsen
dc.subject.meshDogsen
dc.subject.meshMitral Valve Insufficiencyen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshEchocardiography, Three-Dimensionalen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshFemaleen
dc.subject.meshMaleen
dc.titleComparison of the mitral valve morphologies of Cavalier King Charles Spaniels and dogs of other breeds using 3D transthoracic echocardiographyen
dc.title.serialJournal of Veterinary Internal Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2018-05-31en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen

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