Neurocognitive and radiological changes after cranial radiation therapy in humans and rodents: a systematic review

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dc.contributor.authorPerez, Whitney D.en
dc.contributor.authorPerez-Torres, Carlos J.en
dc.date.accessioned2023-01-04T20:30:12Zen
dc.date.available2023-01-04T20:30:12Zen
dc.date.issued2022-05-24en
dc.date.updated2023-01-04T14:34:18Zen
dc.description.abstractBackground: Radiation-induced brain injury is a common long-term side effect for brain cancer survivors, leading to a reduced quality of life. Although there is growing research pertaining to this topic, the relationship between cognitive and radiologically detected lesions of radiation-induced brain injury in humans remains unclear. Furthermore, clinically translatable similarities between rodent models and human findings are also undefined. The objective of this review is to then identify the current evidence of radiation-induced brain injury in humans and to compare these findings to current rodent models of radiation-induced brain injury. Methods: This review includes an examination of the current literature on cognitive and radiological characteristics of radiation-induced brain injury in humans and rodents. A thorough search was conducted on PubMed, Web of Science, and Scopus to identify studies that performed cognitive assessments and magnetic resonance imaging techniques on either humans or rodents after cranial radiation therapy. A qualitative synthesis of the data is herein reported. Results: A total of 153 studies pertaining to cognitively or radiologically detected radiation injury of the brain are included in this systematic review; 106 studies provided data on humans while 47 studies provided data on rodents. Cognitive deficits in humans manifest across multiple domains after brain irradiation. Radiological evidence in humans highlight various neuroimaging-detectable changes post-irradiation. It is unclear, however, whether these findings reflect ground truth or research interests. Additionally, rodent models do not comprehensively reproduce characteristics of cognitive and radiological injury currently identified in humans. Conclusion: This systematic review demonstrates that associations between and within cognitive and radiological radiation-induced brain injuries often rely on the type of assessment. Well-designed studies that evaluate the spectrum of potential injury are required for a precise understanding of not only the clinical significance of radiation-induced brain injury in humans, but also how to replicate injury development in pre-clinical models.en
dc.description.versionAccepted versionen
dc.format.extent19 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1080/09553002.2022.2074167en
dc.identifier.eissn1362-3095en
dc.identifier.issn0955-3002en
dc.identifier.orcidPerez-Torres, Carlos [0000-0003-3352-011X]en
dc.identifier.pmid35511499en
dc.identifier.urihttp://hdl.handle.net/10919/113039en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000801222700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectRadiation-induced brain injuryen
dc.subjectrodent modelsen
dc.subjectcognitionen
dc.subjectimagingen
dc.subjectWHOLE-BRAIN IRRADIATIONen
dc.subjectAPPEARING WHITE-MATTERen
dc.subjectLONG-TERM SURVIVORSen
dc.subjectMAGNETIC-RESONANCE-SPECTROSCOPYen
dc.subjectINDUCED COGNITIVE IMPAIRMENTen
dc.subjectACUTE LYMPHOBLASTIC-LEUKEMIAen
dc.subjectSTEM-CELL TRANSPLANTATIONen
dc.subjectDYSFUNCTION 25 YEARSen
dc.subjectNASOPHARYNGEAL CARCINOMAen
dc.subjectRAT MODELen
dc.subjectRare Diseasesen
dc.subjectBrain Disordersen
dc.subjectBehavioral and Social Scienceen
dc.subjectNeurosciencesen
dc.subjectCanceren
dc.subjectInjury (total) Accidents/Adverse Effectsen
dc.subjectBiomedical Imagingen
dc.subjectAcquired Cognitive Impairmenten
dc.subjectBrain Canceren
dc.subjectMental healthen
dc.subjectNeurologicalen
dc.titleNeurocognitive and radiological changes after cranial radiation therapy in humans and rodents: a systematic reviewen
dc.title.serialInternational Journal of Radiation Biologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherEarly Accessen
dc.type.otherJournalen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Dean of Scienceen

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