Studying the Functional Genomics of Stress Responses in Loblolly Pine With the Expresso Microarray Experiment Management System

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dc.contributor.authorHeath, Lenwood S.en
dc.contributor.authorRamakrishnan, Narenen
dc.contributor.authorSederoff, Ronald R.en
dc.contributor.authorWhetten, Ross W.en
dc.contributor.authorChevone, Boris I.en
dc.contributor.authorStruble, Craig A.en
dc.contributor.authorJouenne, Vincent Y.en
dc.contributor.authorChen, Daweien
dc.contributor.authorvan Zyl, Leonelen
dc.contributor.authorGrene, Ruthen
dc.contributor.departmentComputer Scienceen
dc.contributor.departmentSchool of Plant and Environmental Sciencesen
dc.date.accessioned2017-09-18T10:08:53Zen
dc.date.available2017-09-18T10:08:53Zen
dc.date.issued2002-01-01en
dc.date.updated2017-09-18T10:08:53Zen
dc.description.abstractConception, design, and implementation of cDNA microarray experiments present avariety of bioinformatics challenges for biologists and computational scientists. The multiplestages of data acquisition and analysis have motivated the design of Expresso, asystem for microarray experiment management. Salient aspects of Expresso includesupport for clone replication and randomized placement; automatic gridding, extraction ofexpression data from each spot, and quality monitoring; flexible methods of combiningdata from individual spots into information about clones and functional categories; and theuse of inductive logic programming for higher-level data analysis and mining. Thedevelopment of Expresso is occurring in parallel with several generations of microarrayexperiments aimed at elucidating genomic responses to drought stress in loblolly pineseedlings. The current experimental design incorporates 384 pine cDNAs replicated andrandomly placed in two specific microarray layouts. We describe the design of Expresso aswell as results of analysis with Expresso that suggest the importance of molecularchaperones and membrane transport proteins in mechanisms conferring successfuladaptation to long-term drought stress.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLenwood S. Heath, Naren Ramakrishnan, Ronald R. Sederoff, et al., “Studying the Functional Genomics of Stress Responses in Loblolly Pine With the Expresso Microarray Experiment Management System,” Comparative and Functional Genomics, vol. 3, no. 3, pp. 226-243, 2002. doi:10.1002/cfg.169en
dc.identifier.doihttps://doi.org/10.1002/cfg.169en
dc.identifier.urihttp://hdl.handle.net/10919/79101en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleStudying the Functional Genomics of Stress Responses in Loblolly Pine With the Expresso Microarray Experiment Management Systemen
dc.title.serialComparative and Functional Genomicsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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