Sensitivity of Household Transmission to Household Contact Structure and Size

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dc.contributor.authorMarathe, Achlaen
dc.contributor.authorLewis, Bryan L.en
dc.contributor.authorChen, Jiangzhuoen
dc.contributor.authorEubank, Stephenen
dc.date.accessioned2016-08-22T19:17:11Zen
dc.date.available2016-08-22T19:17:11Zen
dc.date.issued2011-08-01en
dc.description.abstractObjective: Study the influence of household contact structure on the spread of an influenza-like illness. Examine whether changes to in-home care giving arrangements can significantly affect the household transmission counts. Method: We simulate two different behaviors for the symptomatic person; either s/he remains at home in contact with everyone else in the household or s/he remains at home in contact with only the primary caregiver in the household. The two different cases are referred to as full mixing and single caregiver, respectively. Results: The results show that the household’s cumulative transmission count is lower in case of a single caregiver configuration than in the full mixing case. The household transmissions vary almost linearly with the household size in both single caregiver and full mixing cases. However the difference in household transmissions due to the difference in household structure grows with the household size especially in case of moderate flu. Conclusions: These results suggest that details about human behavior and household structure do matter in epidemiological models. The policy of home isolation of the sick has significant effect on the household transmission count depending upon the household size.en
dc.description.versionPublished versionen
dc.format.extent? - ? (7) page(s)en
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0022461en
dc.identifier.issn1932-6203en
dc.identifier.issue8en
dc.identifier.urihttp://hdl.handle.net/10919/72285en
dc.identifier.volume6en
dc.languageEnglishen
dc.publisherPLOSen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000293511200010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons CC0 1.0 Universal Public Domain Dedicationen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/en
dc.subjectPANDEMIC INFLUENZAen
dc.subjectUNITED-STATESen
dc.titleSensitivity of Household Transmission to Household Contact Structure and Sizeen
dc.title.serialPLOS ONEen
dc.typeArticle - Refereeden
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Biocomplexity Instituteen
pubs.organisational-group/Virginia Tech/University Research Institutes/Biocomplexity Institute/SelectedFaculty1en

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