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Characterization of temperature-sensitive strains of Neospora caninum in mice

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dc.contributor.authorLindsay, David S.en
dc.contributor.authorLenz, S. D.en
dc.contributor.authorBlagburn, B. L.en
dc.contributor.authorBrake, D. A.en
dc.date.accessed2014-06-16en
dc.date.accessioned2014-06-20T14:13:09Zen
dc.date.available2014-06-20T14:13:09Zen
dc.date.issued1999-02en
dc.description.abstractTemperature-sensitive (ts) strains of the Neospora caninum tachyzoites were selected by chemical mutagenesis and selection for growth at 32 C. Three ts strains and the parental, N. caninum wild-type strain, NC-1, were examined in the present study for their ability to cause disease in inbred BALB/c mice, outbred ICR mice, and chemically immunosuppressed ICR mice. In BALB/c mice, all 3 strains failed to induce clinical disease, whereas infection with the NC-1 strain caused central nervous system disease and death in some mice. No disease was observed in ICR mice inoculated with the 3 ts strains or the NC-I strain. All immunosuppressed ICR mice inoculated with the NC-1 strain died, whereas no immunosuppressed mice inoculated with the NCts-4 strain and only 1 of 5 mice inoculated with the NCts-8 and NCts-12 strains died. The NCts-4 and NCts-12 strains reverted to a wild-type phenotype when grown at 37 C. Vaccination of BALB/c mice with live, but not frozen NCts-8 strain tachyzoites induced significant (P < 0.05) protection following NC-1 strain challenge.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDavid S. Lindsay, Steve D. Lenz, Byron L. Blagburn and David A. Brake (1999). "Characterization of temperature-sensitive strains of Neospora caninum in mice," The Journal of Parasitology, Vol. 85, No. 1, pp. 64-67. DOI: 10.2307/3285701en
dc.identifier.doihttps://doi.org/10.2307/3285701en
dc.identifier.issn0022-3395en
dc.identifier.urihttp://hdl.handle.net/10919/49028en
dc.identifier.urlhttp://www.jstor.org/stable/3285701en
dc.language.isoenen
dc.publisherAmerican Society of Parasitologyen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjects48 toxoplasma-gondiien
dc.subjectkilled vaccineen
dc.subjectsheepen
dc.subjectchallengeen
dc.subjectpathogenicityen
dc.subjecttachyzoitesen
dc.subjectinfectionsen
dc.subjectimmunityen
dc.subjecthamstersen
dc.subjectmutantsen
dc.subjectparasitologyen
dc.titleCharacterization of temperature-sensitive strains of Neospora caninum in miceen
dc.title.serialJournal of Parasitologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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